Plasma-Levels of Lignocaine After Intramuscular Injection

Relation between Plasma Lignocaine Levels and Induced Haemodynamic Changes

“…after 30 minutes, though the depressant effect of such a procedure on haemodynamics was only moderate and all animals recovered satisfactorily. This probably represents the safe maximum level which might be produced in patients and agrees with the work of Scott et al (1968). A rapid injection of 200 mg. of lignocaine produced a maximum plasma level of 13 8 jpg./ml., and this was associated with a pronounced decrease in myocardial contractile force, and if the amount given was doubled a maximum plasma level of 27.8 jPg./ml.…”

“…body weight given intravenously to patients are isgfcat., and even a sensitive measure of myocardial contractile forcenamely, maximum rate of rise of left ventricular pressure-is unchanged even though lignocaine has a known myocardial depressant action. There was no obvious rise in plasma lignocaine level after thi's dose, though the control values were higher than those measured by Scott et al (1968)., presumably because lignocaine was used as a local anaesthetic for insertion of the catheters. During an infusion of lignocaine at 1 mag./ minute, when no haemodynamic changes occur (Binnion, 1968), the level of plasma lignocaine actually falls from its previously rather high level, which suggests that this rate of infusion is rather low if a satisfactory plsalevel is to be achieved.…”

Oral Lignocaine. Its Absorption and Effectiveness in Ventricular Arrhythmia Control

“…The estimation of blood lignocaine levels after various routes of administration has been described by Bromage and Robson (1961), who studied the intravenous, intramuscular, epidural, and endotracheal routes, and by Scott et al (1968), who studied the intramuscular route. This preliminary investigation was initiated because the oral absorption of lignocaine appeared not to have been studied and because there is a need for an oral antiarrhythmic agent where established drugs have failed.…”

Intramuscular Lignocaine 2% and 10%

“…These low mean levels in volunteers, however, contrast with those found on injection under anaesthesia and in studies on patients with myocardial infarction (Scott et al, 1968;'Bellet et al, 1969). They are not, however, completely unexpected since another volunteer study involving 2-4 mg/kg into the vastus lateralis showed comparable low blood levels (Meyer and Zelechowski, 1970).…”

“…Attention has been drawn to the use of the intramuscular route for prophylaxis or treatment of patients suffering from these arrhythmias, especially in the domiciliary situation (Scott et al, 1968;Bellet et al, 1969). Intramuscular injection might avoid the problems associated with bolus or constant intravenous therapy, especially during transport to hospital.…”