Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria

Dilek, Fatih; Özçeker, Deniz; Özkaya, Enis; Tamay, Zeynep; Yazıcı, Mebrure; Kesgin, Siddika; Koçyiğit, Abdürrahim; Güler, Nermin

doi:10.4168/aair.2016.8.6.522

Cited by 16 publications

(14 citation statements)

References 29 publications

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“…Furthermore, MMP-9, produced by several inflammatory cells, including macrophages, neutrophils, T cells, and mast cells, promotes migration and activation of immune cells by cleaving pro-inflammatory chemokines and cytokines and therefore contributing to the inflammatory processes 68,69. However, some but not all studies showed an association between plasma levels of MMP-9 and disease activity 23,67,70. Therefore, further studies are required before considering MMP-9 as biomarker in the activity and progression of CSU 26.…”

Section: Biomarkers Of Angiogenesis Coagulation and Vascular Dysregumentioning

confidence: 99%

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Puxeddu¹,

Petrelli²,

Angelotti³

et al. 2019

JAA

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Chronic urticaria (CU) is a mast cell-driven disease characterized by the development of wheals, angioedema, or both for more than 6 weeks. The two major sub-types are chronic spontaneous urticaria (CSU) and inducible urticaria. In the last decade different pathophysiological mechanisms, potentially responsible for the development of the disease, have been described. It is likely that the activation of mast cells and basophils in CSU can be the results of immune system dysregulation, activation of the inflammatory cascade, and of the extrinsic coagulation pathway. Some of the mediators involved in the pathophysiological mechanisms of CSU have recently been identified as potential biomarkers useful for the diagnosis, follow-up, and management of the disease, even if they are not yet available in clinical practice. Thus, in this review we discuss new insights in the mediators involved in the pathogenesis of CSU, highlighting their potential role as biomarkers in the activity and progression of the disease and response to therapies.

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Section: Biomarkers Of Angiogenesis Coagulation and Vascular Dysregumentioning

confidence: 99%

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Puxeddu¹,

Petrelli²,

Angelotti³

et al. 2019

JAA

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“…Although elevated levels by themselves cannot explain the entire disease pathogenesis, the increased production of some cytokines, chemokines, or metabolites-including IL-6, vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9), and reactive oxygen species-was reported in previous clinical studies. [46][47][48][49] LXs can inhibit the generation of pro-inflammatory cytokines and chemokines via the inhibition of transcription factors, such as NF-κB and activator protein 1. [50][51][52] In this regard, several in vitro studies and animal models have proven that LXA 4 and its analogues can decrease IL-6 secretion, 6 MMP-9 expression, 53 and VEGF expression 54 and can block ROS generation.…”

Section: Discussionmentioning

confidence: 99%

Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria

et al. 2018

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Dilek F, Özçeker D, Güler EM, Özkaya E, Yazıcı M, Tamay Z, Koçyiğit A, Güler N. Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria. Turk J Pediatr 2018; 60: 527-534. Chronic spontaneous urticaria (CSU) is an idiopathic inflammatory disorder. Despite great research progress, the pathogenesis of the disease is still not fully understood. Lipoxins (LXs) are autacoid lipid metabolites that are the first discovered members of a new genus named called "specialized proresolving mediators". In this study, we aimed to investigate the possible role of LXA 4 in the pathogenesis of CSU. Forty-two children with CSU and 25 healthy children were enrolled in the study. The demographic and clinical features of patients were evaluated, autologous serum skin tests (ASSTs), and routine laboratory assessments were performed. Disease activity was determined using the urticaria activity score. An enzyme-linked immunosorbent assay was used to evaluate LXA 4 plasma levels. The median value of plasma LXA 4 was found to be 60.8 ng/ml (interquartile range, 48.1-71.8) in CSU patients and 137.4 ng/ml (121.4-150.8) in the control group. The difference between the groups was statistically significant (p<0.001). Additionally, the median plasma LXA 4 levels in the ASST-positive patients were significantly reduced compared to the ASST-negative ones (45.8 [36.7-67.6] versus 63.8 [58.3-78.9] ng/ml, respectively, p <0.05).Our results showed that diminished LXA 4 biosynthesis may be a critical part of CSU pathogenesis in children, especially in patients with an autoimmune component.

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“…Recently, the Vascular Endothelial Growth Factor (VEGF) and the Calcitonin Gene-Related Peptide (CGRP) have been observed in the lesions of the patients with the highest levels of vasodilatory factors [58,59]. Of interest, VEGF is also an important vasodilator mediator, through the production of nitric oxide (NO).…”

Section: The Pathophysiology Of Urticariamentioning

confidence: 99%

Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology

et al. 2020

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Background: Urticaria is a disorder affecting skin and mucosal tissues characterized by the occurrence of wheals, angioedema or both, the latter defining the urticaria-angioedema syndrome. It is estimated that 12-22% of the general population has suffered at least one subtype of urticaria during life, but only a small percentage (estimated at 7.6-16%) has acute urticaria, because it is usually self-limited and resolves spontaneously without requiring medical attention. This makes likely that its incidence is underestimated. The epidemiological data currently available on chronic urticaria in many cases are deeply discordant and not univocal, but a recent Italian study, based on the consultation of a national registry, reports a prevalence of chronic spontaneous urticaria of 0.02% to 0.4% and an incidence of 0.1-1.5 cases/1000 inhabitants/year. Methods: We reviewed the recent international guidelines about urticaria and we described a methodologic approach based on classification, pathophysiology, impact on quality of life, diagnosis and prognosis, differential diagnosis and management of all the types of urticaria. Conclusions: The aim of the present document from the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) is to provide updated information to all physicians involved in diagnosis and management of urticaria and angioedema.

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Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria

Cited by 16 publications

References 29 publications

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria

Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology

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