2017
DOI: 10.1186/s13048-017-0338-z
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Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers

Abstract: BackgroundMMP-7 and TIMP-1 may play a role in the pathogenesis of cancer disease. In this study we investigated plasma levels of selected metalloproteinase and its tissue inhibitor in comparison to plasma levels of the commonly accepted tumor markers (CA 125 and HE4) in selected histological types of epithelial ovarian cancer patients as compared to control groups: patients with a benign ovarian tumor and healthy subjects. Plasma levels of MMP-7 and TIMP-1 were determined using ELISA, CA 125 and HE4 – by CMIA … Show more

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Cited by 20 publications
(31 citation statements)
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“…Increased MMP‐9 expression was found to be associated with a poor prognosis, with FIGO (International Federation of Gynecology and Obstetrics) stage, grade of differentiation and LN metastasis in ovarian cancer patients (Li et al, ). Plasma levels of MMP‐7 in combination with commonly accepted tumor markers such as CA125 and HE4 was found to be useful for the diagnosis of epithelial ovarian cancer (EOC) (Simmons et al, ; Bedkowska et al, ) and has also been used in a biomarker panel for early ovarian cancer detection at the point‐of‐care via a multiplexable microfluidic platform (Shadfan et al, ). MMP‐14 and MMP‐2 protein expression is higher in ovarian clear cell carcinoma tissues compared to other ovarian tumor histotypes (serous, endometrioid, mucinous) suggesting that these proteases may contribute to the progression of clear cell carcinomas (Adley et al, ).…”
Section: Diagnosis and Prognosis Of Cancers By Mmpsmentioning
confidence: 99%
“…Increased MMP‐9 expression was found to be associated with a poor prognosis, with FIGO (International Federation of Gynecology and Obstetrics) stage, grade of differentiation and LN metastasis in ovarian cancer patients (Li et al, ). Plasma levels of MMP‐7 in combination with commonly accepted tumor markers such as CA125 and HE4 was found to be useful for the diagnosis of epithelial ovarian cancer (EOC) (Simmons et al, ; Bedkowska et al, ) and has also been used in a biomarker panel for early ovarian cancer detection at the point‐of‐care via a multiplexable microfluidic platform (Shadfan et al, ). MMP‐14 and MMP‐2 protein expression is higher in ovarian clear cell carcinoma tissues compared to other ovarian tumor histotypes (serous, endometrioid, mucinous) suggesting that these proteases may contribute to the progression of clear cell carcinomas (Adley et al, ).…”
Section: Diagnosis and Prognosis Of Cancers By Mmpsmentioning
confidence: 99%
“…Early diagnosis of cancer and determination of its stage allows to increase the survival rate of women suffering from breast cancer by indicating effective treatment methods. Due to many reports regarding the usefulness of tumor markers not only in breast cancer, it is very important that the diagnosis is not limited to diagnostic imaging (Lawicki et al, 2013, Będkowska et al, 2017Ławicki et al, 2016;Zajkowska et al, 2016).…”
Section: Discussionmentioning
confidence: 99%
“…Early diagnosis and determination of cancer stage allows to increase the survival of patients with breast cancer by indicating effective treatment methods. According to many reports regarding the usefulness of tumor markers not only in breast cancer, it is very important that the diagnosis is not limited to diagnostic imaging (Lawicki et al, 2013;Ławicki et al, 2016;Zajkowska et al, 2016;Będkowska et al, 2017).…”
Section: Discussionmentioning
confidence: 99%