Plasma levels of molecular markers of blood coagulation and fibrinolysis in progressive systemic sclerosis (PSS)

Maeda, Manabu; Kachi, Hideki; Mori, Shunji

doi:10.1016/0923-1811(95)00445-9

Cited by 9 publications

(10 citation statements)

References 15 publications

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“…To date, only few investigators have reported that D‐dimer levels are higher in patients with SSc compared with healthy controls 7–10 . In a small series of 28 patients with SSc, Lippi et al.…”

Section: Discussionmentioning

confidence: 99%

“…D‐dimer (a breakdown product of cross‐linked fibrin) has been reported to be a marker of systemic prothrombotic state in patients with cardiovascular diseases 8–15 . Meta‐analyses of prospective studies have shown that plasma levels of D‐dimer were independent predictors of increased risk of coronary heart disease, stroke, peripheral arterial disease as well as cardiovascular death 11–17 …”

Section: Discussionmentioning

confidence: 99%

“…the heart, the kidney and the lungs); previous studies have also highlighted the high prevalence of large vessel disorders in SSc, patients with SSc exhibiting a threefold increase of symptomatic vascular disease compared with controls 2 . The pathogenesis of vascular involvement in SSc is unclear, although it may be due to: (i) vasospasm responsible for episodes of reperfusion injury and free radical‐mediated endothelial dysfunction, which may influence the onset of local thrombotic complications; 1–3 and (ii) a procoagulant state 7–10 …”

mentioning

confidence: 99%

“…2 The pathogenesis of vascular involvement in SSc is unclear, although it may be due to: (i) vasospasm responsible for episodes of reperfusion injury and free radical-mediated endothelial dysfunction, which may influence the onset of local thrombotic complications; 1-3 and (ii) a procoagulant state. [7][8][9][10] D-dimer has proven to be useful in the diagnosis of thrombotic disorders. Increased D-dimer level in plasma has been reported to be a reliable marker of a systemic prothrombotic state, and its measurement might be helpful in predicting thrombotic events.…”

mentioning

confidence: 99%

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Plasma D-dimer concentration in patients with systemic sclerosis

Marie¹,

Borg²,

Hellot

et al. 2007

Br J Dermatol

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The association between high levels of plasma D-dimer (>or=500 ng mL(-1)) and macrovascular involvement in patients with SSc is likely to be an innovative issue. We suggest that D-dimer levels may be a helpful additional test to identify patients with SSc at risk to develop thrombotic arterial complications (peripheral arterial disease, stroke and coronary event); such patients with high levels of plasma D-dimer (>or=500 ng mL(-1)) may require close monitoring of vascular parameters, including especially macrovascular impairment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Plasma D-dimer concentration in patients with systemic sclerosis

Marie¹,

Borg²,

Hellot

et al. 2007

Br J Dermatol

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“…Circulating platelet aggregates Not found [125][126][127] Platelet-leucocyte aggregates Not found [128] [128] -TG Not found [122]; [130] [122]; [125][126][127]; [129][130][131][132][133][134] …”

Section: Platelet Activation Markersmentioning

confidence: 99%

Blood Platelets and Systemic Sclerosis

Lepreux¹,

Solanilla²,

Villeneuve³

et al. 2012

Systemic Sclerosis - An Update on the Aberrant Immune System and Clinical Features

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Cytokine profile and proteome analysis in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis

Rottoli¹,

Magi

Perari³

et al. 2005

Proteomics

143

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The aim of this study was to analyze the type of immune response (Th1, Th2) and protein composition of bronchoalveolar lavage (BAL) of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF). Flow cytometry analysis of intracellular cytokines revealed different patterns: in IPF and SSc Th2 profiles were predominant, whereas in sarcoidosis Th1 prevailed. The proteomic analysis of BAL fluid (BALF) showed that there were quantitative differences between the three diseases. These were more evident between sarcoidosis and IPF, confirming our previous observations, whereas SSc had an intermediate profile between the two, however with some peculiarities. Comparison of BALF protein maps, constructed with the same quantity of total proteins, enabled us to identify the main profiles of the three diseases: an increase in plasma protein prevalent in sarcoidosis and also present in SSc, though for fewer proteins with respect to IPF and a greater abundance of low molecular weight proteins, mainly locally produced, in IPF. These findings are in line with the different pathogenesis of these diseases: IPF is considered a prevalently fibrotic disorder limited to the lung, with intense local production of functionally different proteins, whereas sarcoidosis and SSc are systemic immunoinflammatory diseases.

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Plasma levels of molecular markers of blood coagulation and fibrinolysis in progressive systemic sclerosis (PSS)

Cited by 9 publications

References 15 publications

Plasma D-dimer concentration in patients with systemic sclerosis

Plasma D-dimer concentration in patients with systemic sclerosis

Blood Platelets and Systemic Sclerosis

Cytokine profile and proteome analysis in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis

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