Plasma levels of oxidative stress biomarkers and hospital mortality in severe head injury: A multivariate analysis

Hohl, Alexandre; Gullo, Jackson da Silva; Silva, Cláudia Carvalho Pestana; Bertotti, Melina Moré; Felisberto, Francine; Nunes, Jean Costa; Souza, Bruna de; Petronilho, Fabrícia; Soares, Flávia Mahatma Schneider; Prediger, Rui Daniel; Dal‐Pizzol, Felipe; Linhares, Marcelo Neves; Walz, Roger

doi:10.1016/j.jcrc.2011.06.007

Cited by 59 publications

(55 citation statements)

References 27 publications

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“…Together, those clinical aspects accelerate biochemically the production of free radicals with devastating effects for the cell and by default for the whole biological system [12][13][14]. Thus, this stimulates the so-called 'oxidative stress' [15,16], which has a significant contribution in the clinical status of the patient. Pulmonary dysfunction leads to a series of complications that make recovery impossible [6] through the activation of the hyper-metabolism induced by severe trauma.…”

mentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

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Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

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mentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

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“…However, due to the current paucity of data in the literature, further studies with larger samples are necessary to confirm these recommendations, particularly in the setting of severe TBI. Addressing the utility of psychometric tools for the screening of other neurobehavioral problems following TBI (such as personality changes or anxiety disorders) and investigating the role of biomarkers not only in mortality 14,15 but also in long-term sequelae 16 are important directions for future research. …”

Section: Discussionmentioning

confidence: 99%

“…Demographic, clinical, and psychiatric data were obtained prospectively on the basis of direct evaluation of patients or by interviewing family members, according to our research protocol. [13][14][15][16] Psychiatric assessment Psychiatric interviews were conducted by two experienced psychiatrists (MLS and APD) in outpatient hospital facilities or at the patient's home. Most patients were accompanied by family members (usually a spouse or parents) who were able to provide additional information if necessary.…”

Section: Subjectsmentioning

confidence: 99%

Validity and screening properties of three depression rating scales in a prospective sample of patients with severe traumatic brain injury

Schwarzbold

Diaz

Nunes

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: To evaluate the validity and utility of the Hamilton Rating Scale for Depression (HAM-D), Beck Depression Inventory (BDI), and Hospital Anxiety and Depression Scale (HADS) as screening tools for depression after severe traumatic brain injury (TBI). Methods: Forty-six consecutive survivors of severe TBI were evaluated at a median of 15 months after injury. Receiver operating characteristic (ROC) analysis was performed using HAM-D, BDI, and HADS as predictors, and the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) as gold standard. Results: The area under the curve (AUC) for HAM-D was 0.89, and the optimal cutoff point was 7 (sensitivity 92.9%, specificity 78.1%); for the BDI, the AUC was 0.946 and the optimal cutoff point was 14 (sensitivity 92.3%, specificity 96.7%); for the HADS, the AUC was 0.947 and the optimal cutoff point was 9 (sensitivity 100%, specificity 80.7%); and for the HADS depression subscale, the AUC was 0.937 and the optimal cutoff point was 6 (sensitivity 92.9%, specificity 83.9%). There were no statistically significant differences among the AUCs. Conclusion: Our findings support a high validity and utility for the HAM-D, BDI, and HADS as screening tools for depression in patients with severe TBI, without major changes in standard cutoff points.

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“…On the other hand, fever, seizures and hyperglycemia are examples of SBIs in which increased metabolic demand may outstrip compensatory mechanisms and result in further injury (24). The brain is particularly vulnerable to oxidative stress because of its high rate of oxygen consumption, intensive production of ROS, low antioxidant capacity, high level of transition metal, and polyunsaturated fatty acids (1,4,17,25,26). Oxidative stress is currently thought to be a major contributor to the secondary injury cascade following TBI by ROS/RNS-induced damage to cellular membranes and organelles by lipid peroxidation, protein oxidation and nucleotide breakdown (21).…”

Section: Secondary Injury Mechanismsmentioning

confidence: 99%

“…Traumatic brain injury (TBI) still remains one of the leading causes of death and disability, worldwide (1)(2)(3)(4)(5)(6). TBI constitutes a major global health and socio-economic problem with neurobehavioral sequelae contributing to long-term disability (7).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant therapies in traumatic brain injury: a review

Romero-Rivera¹,

Cabeza-Morales²,

Soto-Zarate³

et al. 2017

Romanian Neurosurgery

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Abstract:Oxidative stress constitute one of the commonest mechanism of the secondary injury contributing to neuronal death in traumatic brain injury cases. The oxidative stress induced secondary injury blockade may be considered as to be a good alternative to improve the outcome of traumatic brain injury (TBI) treatment. Due to absence of definitive therapy of traumatic brain injury has forced researcher to utilize unconventional therapies and its roles investigated in the improvement of management and outcome in recent year. Antioxidant therapies are proven effective in many preclinical studies and encouraging results and the role of antioxidant mediaction may act as further advancement in the traumatic brain injury management it may represent aonr of newer moadlaity in neurosurgical aramamentorium, this kind of therapy could be a good alternative or adjuct to the previously established neuroprotection agents in TBI.

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Plasma levels of oxidative stress biomarkers and hospital mortality in severe head injury: A multivariate analysis

Abstract: Plasma levels of TBARS and carbonyl increase significantly in the first 70 hours after severe TBI but are not independently associated with the hospital mortality.

Cited by 59 publications

References 27 publications

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Validity and screening properties of three depression rating scales in a prospective sample of patients with severe traumatic brain injury

Antioxidant therapies in traumatic brain injury: a review

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