Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study

Holmes, Valerie; Wallace, Julie; Gilmore, William S.; McFaul, P.; Alexander, H. Denis

doi:10.1016/s1043-4666(03)00097-8

Cited by 57 publications

(41 citation statements)

References 32 publications

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“…The results of present study are in consistent with a previous similar study that found an increase in IL-10 level in pregnant compared nonpregnant subjects (Holmes et al, 2003), but our study showed a significant correlation between serum IL-10 concentration and gestational age. Maternal serum IL-10 increased with further increase in pregnancy period.…”

Section: Discussionsupporting

confidence: 93%

“…The mechanism responsible for insulin resistance has not been clearly stated. Recent researches have been shown IL-10 increase insulin sensitivity (Hong et al, 2009;Ye et al, 2006;Holmes et al, 2003;Straczkowski et al, 2005). Insulin sensitivity changes from an enhance state during early pregnancy to an insulin resistant state in late pregnancy (Kirwan et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Normal pregnancy is associated to change in proinflammatory and anti-inflammatory cytokines (Davila et al, 2011;Russell et al, 1997;Holmes et al, 2003). Cytokine balance is important for normal processes of pregnancy and onset of labor (Arntzen et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Jahromi¹,

Farjam²,

Davami³

et al. 2011

OnLine Journal of Biological Sciences

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Problem statement:The purpose of this study was to investigate whether serum of Interleukin-10 (IL-10) Concentration change during normal pregnancy and, if so, to relate these changes corresponding alterations in insulin resistance and blood pressure. Approach: This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively and in 21 healthy non pregnant women. Serum IL-10 concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Insulin resistance value was calculated using the homeostasis model assessment, HOMA-IR. Results: Serum IL-10 concentration was found to be significantly higher in patients in all gestational age as compared non pregnant women. Il-10 level was significantly increased with increase in gestational age. Pregnant women exhibited higher score of HOMA IR compared non pregnant women, but there were no difference in this score between pregnant subjects in different gestational age. There were not significant correlation between IL-10 level with IR and blood pressure. Conclusion: The results of the study show maternal IL-10 level increase with further increase in gestational age and there is no significant correlation between IL-10 level with Mean Arterial blood Pressure (MAP) and IR.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Jahromi¹,

Farjam²,

Davami³

et al. 2011

OnLine Journal of Biological Sciences

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“…This is in congruence with the potential immunomodulatory role of pregnancy on the fetal and maternal immune system, because IL-10 is well known to be a pleiotropic cytokine with significant immunomodulatory properties (24). Indeed, there is a significant increase in serum IL-10 levels in normal human pregnancy compared with nonpregnant controls (25). Although IL-10 does not appear to be crucial for the success of pathogen-free pregnancy in the murine model (26), LPS-induced inflammation during pregnancy does lead to fetal demise in IL-10 null mice (27), implicating the important role of IL-10 in normal pregnancy.…”

Section: Discussionmentioning

confidence: 68%

Fetal–Maternal Alignment of Regulatory T Cells Correlates with IL-10 and Bcl-2 Upregulation in Pregnancy

Santner-Nanan

Straubinger

Hsu

et al. 2013

The Journal of Immunology

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Transplacental immune regulation refers to the concept that during pregnancy, significant cross-talk occurs between the maternal and fetal immune system with potential long-term effects for both the mother and child. In this study, we made the surprising observation that there is a strong correlation of peripheral blood regulatory T (Treg) cells between the mother and the fetus. In contrast, there is no significant Treg cell correlation between paternal fetal dyads (pairs), suggesting that the specific context of pregnancy, rather than the genetic parental similarity to the fetus, is responsible for this correlation. Gene microarray analysis of Treg cells identified a typical IL-10–dependent signature in maternal and fetal Treg cells. In addition, a direct correlation of serum IL-10 protein levels between maternal fetal dyads was observed. Furthermore, we show that maternal serum IL-10 levels correlate with serum estradiol and estriol, implicating hormonal involvement in this alignment. Interestingly, we show that Treg cells possess higher expression of IL-10 receptor α and that Treg cell IL-10 receptor α expression directly correlates with their Bcl-2 expression. Indeed, in vitro data in both humans and mice demonstrate that IL-10 upregulates Bcl-2 specifically in Treg cells but not non-Treg cells. Our results provide evidence for transplacental regulation of cellular immunity and suggest that IL-10 may influence Treg cell homeostasis through its effect on Treg cell Bcl-2 expression. These novel findings have important implications on immune tolerance in pregnancy and beyond in areas of autoimmunity, allergy, and transplantation.

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“…Vassiliadis et al (19), however, have reported that IL-10 concentrations did not change with pregnancy duration. Holmes et al (20) proposed that the possible explanation for differing results may be the small number of studies and the use of inappropriate study methodologies. However, there are no reports in the literature concerning the concentrations of these cytokines in experimental and clinical studies of diabetic pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Plasma concentrations and placental immunostaining of interleukin-10 and tumornecrosis factor-α as predictors of alterations in the embryo-fetal organism and the placental development of diabetic rats

Sinzato

Damasceno

Laufer-Amorim

et al. 2011

Braz J Med Biol Res

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0.05). Prevalence analysis showed that the IL-10 expression followed TNF-α expression, showing a balance between them. STZ rats also presented impaired reproductive performance and reduced plasma IL-10 levels related to damage during early embryonic development. However, the increased placental IL-10 as a compensatory mechanism for the deficit of maternal regulation permitted embryo development. Therefore, the data suggest that IL-10 can be used as a predictor of changes in the embryo-fetal organism and in placental development in pregnant diabetic rats.]]>

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Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study

Cited by 57 publications

References 32 publications

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Fetal–Maternal Alignment of Regulatory T Cells Correlates with IL-10 and Bcl-2 Upregulation in Pregnancy

Plasma concentrations and placental immunostaining of interleukin-10 and tumornecrosis factor-α as predictors of alterations in the embryo-fetal organism and the placental development of diabetic rats

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