Plasma lipid levels and colorectal adenoma risk

Abstract

Purpose Abnormalities in lipid levels have been associated with colorectal neoplasm risk; however, few studies have adjusted for use of cholesterol-lowering medications. The objective of this study was to determine the association of plasma lipid levels with adenoma risk while accounting for statin medication use. Methods We included 254 subjects with advanced adenoma, 246 with single small adenoma, 179 with multiple small adenoma cases, and 403 controls participants in the Tennessee Colorectal Polyp Study who also had plasma lipid measurements performed. Data on the use of statin medications was available for 83.4% of these participants. The association between plasma lipids and adenoma risk was evaluated using logistic regression models. Results Participants in the highest quartile of HDL cholesterol (range 52 – 106 mg/dl) had an adjusted odds ratio of 0.49 (95% CI 0.23, 1.07), 0.35 (95% CI 0.13, 0.91) and 0.22 (95% CI 0.09, 0.54) for single small, multiple small, and advanced adenomas compared to the lowest quartile (range 12 – 34 mg/dl), respectively. Participants with the highest quartile of triglyceride levels (range 178 – 721 mg/dl) had an adjusted odds ratio of 2.40 (95% CI 1.26, 4.55), 1.67 (95% CI 0.66, 4.23) and 2.79 (95% CI 1.25, 6.23) for single small, multiple small, and advanced adenoma, respectively compared to the lowest quartile (range 40 – 84 mg/dl). When restricted to individuals with known statin medication use adjusting for statin use did not appreciably affect these results. Conclusions We found a direct association between triglyceride plasma levels and an inverse association between plasma HDL cholesterol levels and adenoma risk. Both effects were not appreciably changed when accounting for the regular use of statin medication.

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

“…Dyslipidemia showed univariate but not independent associations with ACN. Considering contradictory results of the previous studies,46,47 further studies are warranted to clarify the independent significance of dyslipidemia for ACN. Notably, a family history of CRC was not related to the risk of ACN in our population, which is in agreement with recent studies involving large numbers of asymptomatic Koreans [48][49][50][51].…”

Potential anti-tumor effect of a nanoliposomal antiPCSK9 vaccine in mice bearing colorectal cancer

“…Abnormal levels of plasma lipids have been shown to be significantly associated with colon carcinoma risk [1][2][3][4][5][6][7][8]. Higher levels of low-density lipoprotein (LDL) cholesterol (LDL-C) have been reported to correlate with higher prevalence [9,10] and risk [11,12] of colon cancer.…”

High level of serum apolipoprotein A-I is a favorable prognostic factor for overall survival in esophageal squamous cell carcinoma

“…Cholesterol synthesis is enhanced in cancer cells compared with normal cells, as tumor cells need excess cholesterol and cholesterol biosynthesis pathway intermediates to maintain a high level of proliferation [ 10 ]. Evidence for the activation of lipid metabolism in tumor cells can be provided by quantifying the products of lipid metabolism such as apolipoprotein A-I (ApoA-I) in the serum of cancer patients [ 11 – 13 ].…”