Plasma Lipid Profiles of Women With Intrahepatic Cholestasis of Pregnancy

Dann, A T; Kenyon, A; Wierzbicki, Anthony S.; Seed, Paul; Shennan, Andrew; Tribe, Rachel

doi:10.1097/01.aog.0000189096.94874.9c

Cited by 72 publications

(69 citation statements)

References 31 publications

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“…This association was lost in women treated with UDCA. The findings of this prospective study support the observations made by ourselves and others that ICP is associated with increased rates of GDM (13,14,17) and characterized by elevated serum levels of glucose (20), triglycerides, and total and LDL cholesterol, as well as a fall in HDL cholesterol (15,16,25).…”

Section: Discussionsupporting

confidence: 90%

“…In contrast, the concentration of HDL cholesterol was reduced in ICP (15,16,25), a finding that is not seen in mice deficient in fxr. FXR stimulates expression of peroxisome proliferatoractivated receptor-a (10), a nuclear receptor responsible for the regulation of expression of apolipoprotein A1, a major protein component of HDL (40).…”

Section: Bile Acids and Glucose And Lipid Homeostasismentioning

confidence: 80%

“…An association between glucose intolerance and dyslipidemia in ICP has previously been reported (5,(13)(14)(15)(16), with a recent retrospective study reporting an increased incidence of gestational diabetes mellitus (GDM) following the onset of cholestasis, suggesting that this may be the result of aberrant bile acid homeostasis (17).…”

mentioning

confidence: 95%

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The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

et al. 2014

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OBJECTIVEQuantification of changes in glucose and lipid concentrations in women with intrahepatic cholestasis of pregnancy (ICP) and uncomplicated pregnancy and study of their influence on fetal growth. RESEARCH DESIGN AND METHODSA prospective study comparing metabolic outcomes in cholestastic and uncomplicated singleton pregnancies was undertaken at two university hospitals in the U.K. and U.S. from 2011-2014. A total of 26 women with ICP and 27 control pregnancies with no prior history of gestational diabetes mellitus were recruited from outpatient antenatal services and followed until delivery. Alterations in glucose, incretins, cholesterol, and triglycerides were studied using a continuous glucose monitoring (CGM) system and/or a standard glucose tolerance test (GTT) in conjunction with GLP-1 and a fasting lipid profile. Fetal growth was quantified using adjusted birth centiles. RESULTSMaternal blood glucose concentrations were significantly increased in ICP during ambulatory CGM (P < 0.005) and following a GTT (P < 0.005). ICP is characterized by increased fasting triglycerides (P < 0.005) and reduced HDL cholesterol (P < 0.005), similar to changes observed in metabolic syndrome. The offspring of mothers with ICP had significantly larger customized birth weight centiles, adjusted for ethnicity, sex, and gestational age (P < 0.005). CONCLUSIONSICP is associated with impaired glucose tolerance, dyslipidemia, and increased fetal growth. These findings may have implications regarding the future health of affected offspring.

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Section: Discussionsupporting

confidence: 90%

Section: Bile Acids and Glucose And Lipid Homeostasismentioning

confidence: 80%

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The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

et al. 2014

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“…A reduction in serum cholesterol levels can result in a decrease in intra-hepatic circulation of bile acids and prevent production of excessive bile [37]. Minimizing the liver damage caused by toxic bile acids can inhibit the alteration of lipid metabolism [38]. On the other hand, the accumulation of cholesterol during cholestasis leads to an increase in cholesterol content of the hepatic cell membrane, dysfunction in integral protein of membrane and a decrease in membrane fluidity [3].…”

Section: Discussionmentioning

confidence: 99%

Effects of folic acid on dyslipidemia and serum homocysteine in a rat model of cholestasis and hepatic fibrosis

Mohammadian¹,

Eidi²,

Mortazavi³

et al. 2015

pjp

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The liver is the major site for storage and metabolism of folate. Folate deficiency is common in many liver diseases and causes severe effects on cellular metabolism and increases oxidative stress and the homocysteine (Hcy) level. The objective of this research was to investigate the effects of folic acid on dyslipidemia and serum Hcy concentrations in an experimental rat model of cholestasis. Eighty-one male Wistar rats were divided into nine groups: control, sham-operated, folic acid control, bile duct-ligated (BDL), and BDL+ folic acid groups. In folic acid treated groups, folic acid (1, 5, and 10 mg/kg body weight) was given orally for 28 days. After taking blood and liver samples, plasma lipid profiles and Hcy and hepatic reduced and oxidized glutathione concentrations were measured. Histopathological features of cholestasis were assessed by Masson's trichrome staining. Treatment of folic acid in BDL rats significantly prevented the progression of hepatic fibrosis and improved the serum and liver biochemical changes. These results suggest that folic acid protects the liver against cholestasis by reducing serum Hcy and by its antioxidant properties. Folic acid can be an important therapeutic intervention in dyslipidemia caused by cholestasis.

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“…Gallbladder motor dysfunction and stasis also contribute to gallstone formation [21] . Intrahepatic cholestasis is associated with dyslipidemia, which might also contribute to the pathogenesis of the disease [22] .…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Biliary and Serum Lipid Profiles in Patients of Obstructive jaundice due to stones in common bile duct

Nasar¹

2018

jmscr

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Plasma Lipid Profiles of Women With Intrahepatic Cholestasis of Pregnancy

Abstract: II-2.

Cited by 72 publications

References 31 publications

The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

Effects of folic acid on dyslipidemia and serum homocysteine in a rat model of cholestasis and hepatic fibrosis

A Comparative Study of Biliary and Serum Lipid Profiles in Patients of Obstructive jaundice due to stones in common bile duct

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