Plasma lipids in HIV‐infected patients: a prospective study in 95 patients

Constans, J.; Pellegrin, Jean‐Luc; Peuchant, Evelyne; Dumon, M.F.; Pellegrin, Isabelle; Sergeant, Claire; Simonoff, M.; Brossard, G.; Barbeau, P.; Fleury, Hervé; Clerc, M; Leng, B; Conri, C.

doi:10.1111/j.1365-2362.1994.tb02185.x

Cited by 161 publications

(110 citation statements)

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“…Before widespread HAART use, elevated triglyceride and low HDL-C levels were reported in HIV infection [11,12]. In the HAART era, several studies have shown higher total cholesterol, LDL-C and triglyceride levels associated with PI use [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

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Increased serum lipids are associated with higher CD4 lymphocyte count in HIV‐infected women

Floris-Moore

Howard

et al. 2006

HIV Medicine

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ObjectiveHighly active antiretroviral therapy (HAART) has been associated with dyslipidaemia; however, the roles of immune status and non-HIV-disease risk factors remain unclear. MethodsA cross-sectional analysis of fasting lipids was carried out for 231 women, of whom 132 were HIVinfected and 99 were uninfected. The concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and apolipoprotein B (apo B) were measured. CD4 lymphocyte count, hepatitis C status, demographics, diet, and anthropometrics were also assessed. ResultsA total of 132 women were HIV-infected [30 were antiretroviral-naive, 68 were on protease inhibitors (PIs), and 34 were on non-PI HAART]. HIV infection was associated with higher triglycerides, lower HDL-C, and, among obese women, higher total cholesterol and LDL-C. Non-PI and PI HAART were each independently associated with higher total cholesterol, LDL-C, and apo B, compared with being ART-naive. Among HIV-infected women, after adjustment for HAART use, women with a CD4 lymphocyte count ! 500 cells/mL had total cholesterol 41.8 mg/dL (P 5 0.002) and LDL-C 28.8 mg/dL (P 5 0.01) higher, on average, than women with a CD4 count o200 cells/mL. Women with a CD4 count of 200-499 cells/mL had total cholesterol 26.31 mg/dL higher, on average, than those with a CD4 count o200 cells/mL (P 5 0.04), although differences in LDL-C did not reach significance (15.51 mg/dL; P 5 0.12). A higher CD4 count was also associated with higher apo B (Po0.001). Active hepatitis C infection was associated with lower total cholesterol, LDL-C, triglycerides, and apo B. ConclusionsHigher CD4 lymphocyte counts were associated with higher lipid levels, suggesting that immune competence may independently affect the dyslipidaemia seen in the HAART era. In addition, it is important that hepatitis C status be assessed in studies of dyslipidaemia in the HIV-infected population.Keywords: antiretroviral therapy, drug use, dyslipidaemia, women IntroductionHighly active antiretroviral therapy (HAART) has dramatically increased life expectancy among HIV-infected persons. However, several metabolic complications have been reported in association with HAART, including insulin resistance and dyslipidaemia [1][2][3][4][5]. There have been reports of high total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride levels associated with protease inhibitor (PI) use [6][7][8]. High total cholesterol and triglyceride levels have also been reported in patients on non-PI HAART regimens [9,10]. In addition, low high-density lipoprotein (HDL-C) levels and hypertriglyceridaemia have been described in HIV-infected patients not receiving antiretroviral therapy [11][12][13]. 421Other factors, including dietary fat intake, physical activity, obesity, and genetics, may influence lipid levels [14][15][16]. Low levels of adiponectin, an adipocyte-derived peptide inversely related to insulin resistance and dyslipidaemia, have been reported in HIV-i...

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Section: Discussionmentioning

confidence: 99%

“…High total cholesterol and triglyceride levels have also been reported in patients on non-PI HAART regimens [9,10]. In addition, low high-density lipoprotein (HDL-C) levels and hypertriglyceridaemia have been described in HIV-infected patients not receiving antiretroviral therapy [11][12][13]. …”

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confidence: 99%

Increased serum lipids are associated with higher CD4 lymphocyte count in HIV‐infected women

Floris-Moore

Howard

et al. 2006

HIV Medicine

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“…Constans et al 29 actually observed prognostic implication of these alterations. The lower the TCD4+ lymphocytes count, the higher the triglycerides level and the lower the HDL-cholesterol levels.…”

Section: Discussionmentioning

confidence: 98%

Níveis de atividade física e alterações metabólicas em pessoas vivendo com HIV/AIDS

Romancini

Guariglia

Nardo

et al. 2012

Rev Bras Med Esporte

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The introduction of Highly Active Antiretroviral Therapy (HAART) has deeply changed the course of HIV infection with increase in survival and improvement in quality of life as well as partial restoration of the immune system. After about ten years from the HAART use, the effects of combination treatment / virus started to come out. Among these, we can mention changes in lipid metabolism with hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia and redistribution of body fat as risk factors for cardiovascular disease. Observational studies with people living with HIV / AIDS evidence that when an individual finds out that he/she is an HIV/AIDS patient, he/she end ups feeling fear or shame, reducing hence social circle, work and leisure activities, and becomes isolated at home or in small groups which have common identity of HIV / AIDS patients. The purpose of this work was to evaluate the relationship between the level of habitual physical activity and recreation of people living with HIV / AIDS and its relation with metabolic changes. The patients were classified into active and sedentary, using the Habitual Physical Activity questionnaire proposed by Baecke and validated for HIV / AIDS patients. Classification was conducted according to the recommendations of the American College of Sports Medicine. Metabolism was assessed through plasma levels of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides, using commercial kits. The sample consisted of 65 HIV patients who used HAART for at least five years. 64.6% were classified as sedentary and 35.4% as active. The study shows a direct relationship between physical activity level and higher levels of HDL -cholesterol in HIV / AIDS. HDL -Cholesterol is a lipoprotein of cardiovascular protection and, although other assessed parameters have not shown difference, these results highlight the need for additional studies on risk factors and physical activity for HIV / AIDS enabling proposals for specific interventions for these patients.

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“…Therefore, the predisposition to atherosclerosis results from cumulative exposure to the virus and from metabolic changes secondary to the use of PI, thus determining an unfavorable metabolic profile characterized by hypertriglyceridemia, low HLD-c and insulin resistance observed in 25 to 60% of the patients 6 .…”

Section: Introductionmentioning

confidence: 99%

Estudo da reatividade vascular em portadores de HIV com e sem uso de inibidor de protease

Teixeira¹,

Mesquita²,

Ribeiro³

et al. 2009

Arq. Bras. Cardiol.

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Plasma lipids in HIV‐infected patients: a prospective study in 95 patients

Cited by 161 publications

References 14 publications

Increased serum lipids are associated with higher CD4 lymphocyte count in HIV‐infected women

Increased serum lipids are associated with higher CD4 lymphocyte count in HIV‐infected women

Níveis de atividade física e alterações metabólicas em pessoas vivendo com HIV/AIDS

Estudo da reatividade vascular em portadores de HIV com e sem uso de inibidor de protease

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