Plasma lipids in patients with chronic renal failure

Kaye, Josse; Moorheàd, J. F.; Wills, M. R.

doi:10.1016/0009-8981(73)90071-5

Cited by 21 publications

(7 citation statements)

References 15 publications

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“…The lipid increment has been shown to be primarily in the pre-beta fraction (VLDL) which is triglyceride-rich (9,13,22,24,32,36). Similarly, decreased levels in the alpha lipoproteins (HDL) have been described in adult uremic patients and are attributed to abnormally low levels of alpha lipoprotein cholesterol content (5,22,32,36).…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia in Children with Chronic Renal Insufficiency

et al. 1981

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SummaryTotal serum cholesterol, phospholipids, and triglyceride levels, lipoprotein fractionation, and plasma parathormone levels were measured in a group of 31 nonnephrotic children with various levels of renal function and on hemodialysis. Group A served as controls and consisted of eight healthy children with glomerular fdtration rate (GFR) greater than 110 ml/min/1.73 m2. Group B consisted of six children with GFR of 60 to 95 ml/min/1.73 m2. Group C consisted of nine children with GFR of 10 to 40 ml/min/ 1.73 m2, and group D consisted of eight children on maintenance hemodialysis with GFR of 0 to 5 ml/min/1.73 m2. Among the groups, there were no significant differences in total serum cholesterol and phospholipid levels. A significant ( P < 0.05) increase in triglyceride levels was observed in patient groups C and D.Lipoprotein fractionation revealed a significant increase (P < 0.05) in the pre-beta lipoprotein levels (very low density lipoproteins) in patients in group D with 63% of these patients demonstrating a type IV lipoprotein pattern. There were no significant differences observed in the beta lipoproteins (low-density lipoproteins). However, the alpha lipoproteins (high-density lipoproteins) decreased significantly ( P < 0.05) in patients whose GFR was below 40 ml/min/1.73 m2 (group C) as well as patients in group D.Absolute plasma parathormone levels did not significantly correlate with serum triglyceride levels and remained normal until after the onset of hemodialysis when they increased significantly in all patients. SpeculationEvidence has been accumulating over the past few years that chronic hemodialysis and renal transplant adult patients have shortened survival because of accelerated atherosclerotic cardiovascular disease for which hyperlipidemia could be one of several etiologic factors. Similar epidemiologic studies have not been performed in children. We have demonstrated for the first time in children that alterations in serum triglycerides and alpha lipoproteins (high-density lipoproteins) occur early in chronic renal insufficiency and before the onset of uremia when the glomerular fdtration rate falls below 40 ml/min/1.73 m2. These lipid abnormalities become further aggravated with the onset of hemodialysis. If pediatric renal transplant patients show similar lipid abnormalities, then the potential for cardiovascular complications will be of importance in the early medical management of these children.

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Section: Discussionmentioning

confidence: 99%

Hyperlipidemia in Children with Chronic Renal Insufficiency

et al. 1981

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“…INSULIN Bagdade et al (1968) reported that in both dialysed and undialysed uraemic patients plasma immunoreactive insulin concentrations were increased. In contrast Kaye et al (1973) reported that there was no significant difference between the mean immunoreactive insulin concentrations in a group of undialysed uraemic patients and those in the control subjects, though the mean glucose concentration was increased in the uraemic group. Furthermore, these workers could not find any correlation between insulin and triglyceride concentrations in either the control subjects or the patients; the insulin concentrations showed a similar distribution in both groups.…”

Section: Blood Lipidsmentioning

confidence: 85%

“…A valuable 179 one was that of Kaye et al (1973) in which they studied 15 undialysed patients (8 male, 7 female), who were selected on a clinical and biochemical basis as having chronic renal failure without gross proteinuria. All had a creatinine clearance of less than 50 ml/rnin and were uraemic.…”

Section: Blood Lipidsmentioning

confidence: 99%

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Disorders of Carbohydrate and Lipid Metabolism in Renal Disease: A Short Review

Cramp

Wills

1975

Ann Clin Biochem

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“…The range of values obtained from 13 fasting and resting control subjects was 117 to 835 ,umol/l (as stearic acid), with a mean (±s.e. mean) of 359±66 Lrmol/l (Kaye, Moorhead and Wills, 1973).…”

Section: Methodsmentioning

confidence: 91%

Plasma bilirubin and serum free fatty acids after myocardial infarction

Cowan¹,

Thompson²,

Kaye³

et al. 1981

Postgraduate Medical Journal

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SummaryFasting concentrations of plasma bilirubin were measured in 34 patients on admission to hospital and daily for 7 days after uncomplicated myocardial infarction. Mean concentrations increased significantly to reach maximum levels on the second day after admission, and fell during the following 5 days to reach the admission level by the 7th day. Unconjugated bilirubin accounted for most of this rise. Serum concentrations of free fatty acids (FFA), measured simultaneously in 12 patients, were highest within 12 hr of the onset of symptoms, when their level was significantly higher than at any time after the first day. It is suggested that the transient hyperbilirubinaemia after uncomplicated myocardial infarction is frequent and may result from interference by FFA with bilirubin metabolism.

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Plasma lipids in patients with chronic renal failure

Cited by 21 publications

References 15 publications

Hyperlipidemia in Children with Chronic Renal Insufficiency

Hyperlipidemia in Children with Chronic Renal Insufficiency

Disorders of Carbohydrate and Lipid Metabolism in Renal Disease: A Short Review

Plasma bilirubin and serum free fatty acids after myocardial infarction

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