Plasma Lipoprotein(a) Indicates Risk for 4 Distinct Forms of Vascular Disease

Lipoprotein(a) and Cardiovascular Disease in Ethnic Chinese: The Chin-Shan Community Cardiovascular Cohort Study

“…5 is a low-density lipoprotein particle in which apolipoprotein B-100 is linked by a single disulfide bridge to apolipoprotein(a), which is structurally similar to plasminogen (1,2 ). The dual effects of atherogenicity and thrombogenesis from Lp(a) particles make it plausible to investigate the role of Lp(a) in atherosclerosis in a population; however, although many cross-sectional studies of hospital-based populations have consistently shown that Lp(a) is related to various vascular diseases (3)(4)(5)(6), the evidence provided by many prospective cohort studies has been equivocal. In addition, previous large-scale prospective cohorts were restricted to women (7 ), to men (8 ), or to an older population (9,10 ).…”

Comparison of Fasting and Non Fasting Lipid Profile and Lipoprotein (a) in Healthy Adult Population

“…4 Dyslipidaemia is considered one of major predisposing risk factor for atherosclerosis, American Academy of Clinical Endocrin- stroke, peripheral artery occlusive disease (PAOD) and abdominal aortic aneurysm. 12 Its incorporation into plaque and high affinity binding to glycosaminoglycans and fibronectin suggest a direct atherogenic action in combination with elevated cholesterol. The optimal level of Lp(a) should not be greater than 20mg/dl.…”

Lipoprotein(a) – Einfluss auf die kardiovaskuläre Manifestation

“…Es liegen nur wenige Daten über die Auswirkung auf den Koronarstatus und kardiale Ereignisse bei einer isolierten exzessiven Lp(a)-Erhöhung vor [20].…”

“…fünf Jahre signifikant niedriger war als in der Vergleichsgruppe. Bei der Frage nach einem Schwellenwert für das Auftreten einer KHK wird in der Literatur auf den stufenweisen Anstieg des Risikos für einen Myokardinfarkt bei ansteigender Lp(a)-Konzentration hingewiesen [20]. Ein Schwellenwert konnte nicht ermittelt werden.…”