Plasma lipoprotein and apolipoprotein levels in Taipei and Framingham.

Abstract

We compared the plasma lipoprotein cholesterol, triglyceride, apolipoprotein (apo) A-I, apoB, and lipoprotein (a) [Lp(a)] concentrations in a low coronary heart disease (CHD) risk population (n=440) in Taipei with a high CHD risk population (n=428) in Framingham matched for age, sex, and menopausal status. Taipei men had significantly lower low-density lipoprotein cholesterol (LDL-C) (-20 mg/dL, -14%,P<.01) andapoB (-7 mg/dL, -6%,P<.05) levels and significantly higher high-density lipoprotein cholesterol (HDL-C) levels (6 mg/dL, 13%, P<.01) than Framingham men. Taipei women had significantly lower LDL-C (-18 mg/dL, -15%, / > <.01) and higher HDL-C (4 mg/dL, 7%, P<.01) levels than Framingham women. Median concentrations and distributions of Lp(a) by sex were similar in Taipei and Framingham. After adjusting for body mass index and smoking status, only differences in total cholesterol and LDL-C levels remained significantly different for both sexes between the two populations (P<.01). Gender differences for lipids within populations were similar. After adjusting for age, body mass index, and smoking status, women in both Taipei and Framingham had significantly lower mean triglyceride, LDL-C, and apoB levels and significantly higher HDL-C and apoA-I levels than men. Postmenopausal women in Taipei had significantly higher mean total cholesterol, LDL-C, HDL-C, apoA-I, apoB, and Lp(a) levels than premenopausal women (P<.05), whereas in Framingham postmenopausal women had significantly higher total cholesterol, triglyceride, LDL-C, and apoB levels than premenopausal women (P<.05). Our data are consistent with the concept that plasma lipoprotein cholesterol levels (especially LDL-C) but not apolipoprotein values explain some of the twofold difference in age-adjusted CHD mortality between these two populations. (Arterioscler Thromb. 1993;13:1429-1440 KEY

Phenotypic Variation in Heterozygous Familial Hypercholesterolemia

“…Data for the apo(a) and apoE phenotypes/genotypes were not available for the original Chinese FH patients, but it is unlikely that variation in these genes alone is a cause for the highly significant difference in phenotype observed in this study between the Chinese FH heterozygote cohorts of such similar racial origin. Lp(a) concentrations were higher in the Canadian Chinese FH families in this study than in other Chinese general populations, 16 but no significant difference in Lp(a) concentration between individuals with and without FH within these FH families was observed. In addition, it is unlikely that high Lp(a) concentrations were causally related to the higher prevalence of CAD in the Canadian Chinese FH cohort, as no significant difference in Lp(a) levels between FH subjects with and without CAD was observed.…”

“…16 However, no differences in Lp(a) concentrations were observed between the FH and non-FH individuals from the Canadian Chinese families participating in this study (data not shown) nor between Chinese Canadian FH heterozygotes with CAD (743.7Ϯ463, nϭ4) and those without CAD (1219.3Ϯ783.9, nϭ3), although it should be pointed out that the sample numbers were small and there was considerable variability in Lp(a) concentration.…”

Effect of conjugated equine estrogen in combination with two different progestogens on the risk factors of coronary heart disease in postmenopausal Chinese women in Taiwan: a randomized one‐year study

“…The higher HDL‐C levels found in our study are consistent with the reports of Lyu et al (31) and Torng et al (32), whose participants were also from Taipei City. Lyu et al reported that the age‐adjusted mortality rate of CHD is relatively low (half) among the Chinese in Taiwan as compared with the people in the Framingham study.…”

Effect of Apolipoprotein E Genotype on Association of Menopausal Status with Lipid Level in Japanese Women

“…In particular, a marked difference in the LDL-cholesterol level was observed, which agrees with the results reported for European and American populations. 5,6,21) Apo E genotypes were determined by a highly accurate DNA analysis using the PCR-SSCP method, 18) by which the base sequence of the entire apo E-coding region and genotypes were determined, to avoid confusion caused by multiple variant genotypes. After adjustment for age and BMI, it was found that the apo E genotype significantly affected LDL-cholesterol (p < 0.001) and serum total cholesterol (p < 0.01) levels.…”