Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

Barber, Marcus; Risis, Steve; Yang, Christine; Meikle, Peter J.; Staples, Margaret; Febbraio, Mark A.; Bruce, Clinton R.

doi:10.1371/journal.pone.0041456

Cited by 306 publications

(281 citation statements)

References 29 publications

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“…These results imply that the plasma lipidome may have an independent and additive utility in detection of insulin resistance and central obesity-conditions common in Mexican Americans ( 28,40 ). Lipidomic studies conducted in the past ( 14,(41)(42)(43) have been able to detect some key associations of specifi c lipid species with insulin resistance, but our results indicate that the entire plasma lipidome may be associated with substantial changes in these traits. In the context of VC models as used in this study, it is important to note that these contributions of the plasma lipidome are independent of the polygenic component, indicating that the plasma lipidome may be partially tracking the environmental aspects of obesity and insulin resistance.…”

Section: Discussionmentioning

confidence: 60%

Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Kulkarni

Meikle

Mamtani

et al. 2014

Journal of Lipid Research

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The full spectrum of lipid molecules in human plasma and their potential role in human health and disease are areas of intense interest ( 1-9 ). This interest owes substantially to the sophisticated technologies that make it possible to accurately capture and quantify the human lipidome ( 8, 10 ). Associative evidence gleaned from plasma lipidomic studies promises vital contributions to biomarker researchan important mainstay of the continued efforts for chronic disease prevention. The plasma lipidomic profi le of humans exhibits a wide range of diversity ( 11,12 ) and is associated with several conditions including obesity ( 13, 14 ), hypertension ( 14-16 ), disorders of glucose metabolism ( 13, 17 ), metabolic syndrome (MS) ( 10, 18 ), cardiovascular diseases ( 19 ), cystic fi brosis ( 20 ), nicotine consumption ( 21 ), and response to antilipid treatment ( 22 ).Lipidomic association studies conducted in the context of families have an important consideration that the concentrations of the plasma lipid species might be phenotypically as well as genetically correlated with each other ( 23 ) especially in related individuals. In that case, it is Abstract Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the highresolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic infl uences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22% of variability in the homeostatic model of assessment-insulin resistance trait and 16% to 22% variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in

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Section: Discussionmentioning

confidence: 60%

Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Kulkarni

Meikle

Mamtani

et al. 2014

Journal of Lipid Research

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“…For instance, mice fed a low fat diet exhibit lower circulating C20:0, C22:0, and C24:0 GlcCer levels as compared with mice fed a high fat diet (Barber et al. 2012). It is important to recognize that the observed ceramide and GlcCer‐lowering response associated with increased fruit and vegetable consumptions developed even though dietary fructose intake increased.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study

et al. 2017

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The 2010 USDA Dietary Guidelines for Americans (DGA) recommends a diet largely composed of fruit and vegetables. Consuming a diet high in fruit and vegetables and low in refined carbohydrates and saturated fat may reduce an individual's risk for type 2 diabetes, nonalcoholic fatty liver disease, low‐grade chronic inflammation, and metabolic syndrome (MetS). Several recent studies have implicated the bioactive sphingolipid ceramide as an associative and causative biomarker for the development of these conditions. Considering that the intake of fruit and vegetables is frequently inadequate in young adults, we performed a pilot investigation to assess the efficacy of a free‐living fruit and vegetable intervention on overall metabolic health, circulating ceramide supply, and inflammatory status in young adults. We discovered that adoption of the recommended DGA for fruit and vegetable intake for 8 weeks decreased waist circumference, systolic blood pressure, and circulating cholesterol. Lipidomics analysis revealed that nutritional intervention can lower circulating ceramides, including C24:0 ceramide, a known inhibitor of insulin signaling. Unexpectedly, we observed an increase in C16:0 ceramide, suggesting that this form of ceramide in circulation is not associated with metabolic disease in humans. We also observed an improved inflammatory status with enhanced fruit and vegetable intake that was correlated with ceramide concentrations. These data suggest that adopting the recommended DGA is associated with a reduction of many, but not all, ceramide species and may help to prevent or mitigate MetS. Future research needs to assess whether the ceramide‐lowering ability of nutritional intervention is associated with reduced risk of developing metabolic disease.

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“…Previous reports suggested the possibility of relationships between plasma LPC levels and dampnessphlegm pattern. It was known that dampness-phlegm pattern was related to obesity and hyperlipidemia [103,104], and some metabonomic analyses showed that plasma LPC levels were also associated with obesity [105,106].…”

Section: Strokementioning

confidence: 99%

UPLC-based metabonomic applications for discovering biomarkers of diseases in clinical chemistry

Zhao

Cheng

Vaziri

et al. 2014

Clinical Biochemistry

120

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a b s t r a c t a r t i c l e i n f oObjectives: Metabonomics is a powerful and promising analytic tool that allows assessment of global lowmolecular-weight metabolites in biological systems. It has a great potential for identifying useful biomarkers for early diagnosis, prognosis and assessment of therapeutic interventions in clinical practice. The aim of this review is to provide a brief summary of the recent advances in UPLC-based metabonomic approach for biomarker discovery in a variety of diseases, and to discuss their significance in clinical chemistry.Design and methods: All the available information on UPLC-based metabonomic applications for discovering biomarkers of diseases were collected via a library and electronic search (using Web of Science, Pubmed, ScienceDirect, Springer, Google Scholar, etc.).Results: Metabonomics has been used in clinical chemistry to identify and evaluate potential biomarkers and therapeutic targets in various diseases affecting the liver (hepatocarcinoma and liver cirrhosis), lung (lung cancer and pneumonia), gastrointestinal tract (colorectal cancer) and urogenital tract (prostate cancer, ovarian cancer and chronic kidney disease), as well as metabolic diseases (diabetes) and neuropsychiatric disorders (Alzheimer's disease and schizophrenia), etc.Conclusions: The information provided highlights the potential value of determination of endogenous lowmolecular-weight metabolites and the advantages and potential drawbacks of the application of UPLC-based metabonomics in clinical setting.

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Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

Cited by 306 publications

References 29 publications

Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study

UPLC-based metabonomic applications for discovering biomarkers of diseases in clinical chemistry

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