Plasma Membrane-derived Vesicles (PMVs) in G6PD Deficient Patients

Antwi‐Baffour, Samuel

doi:10.15226/soji.2013.00105

Cited by 4 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This ability was demonstrated for the first time in patients with idiopathic thrombocytopaenic purpura (ITP) 16 . They are also indicated in a number of autoimmune diseases as well as malaria infection whereby the number of PEVs in the plasma of the affected individual is known to increase 17 . Subsequently, PEVs happens to be the most abundant EVs in the blood although EVs in the periphery can also arise from erythrocytes, granulocytes, monocytes, lymphocytes, and endothelial cells, which usually circulate at lower numbers [18,19a] 18 .…”

Section: Historical Background Of Pevsmentioning

confidence: 99%

Understanding the biosynthesis of platelets‐derived extracellular vesicles

Antwi‐Baffour

Adjei

Aryeh

et al. 2015

Immunity Inflam & Disease

View full text Add to dashboard Cite

Platelet-derived extracellular vesicles (PEVs) are described as sub-cellular vesicles released into circulation upon platelets shear stress, activation, injury, or apoptosis. They are considered as universal biomarkers in a wide range of physiological and pathological processes. They are of tremendous significance for the prediction, diagnosis, and observation of the therapeutic success of many diseases. Understanding their biosynthesis and therefore functional properties would contribute to a better understanding of the pathological mechanisms leading to various diseases in which their levels are raised and they are implicated. The review takes a critical look at the historical background of PEVs, their structural components, the mechanism of their formation, physiological, and exogenous stimuli inducing their release and their detection. It concludes by highlighting on the importance of undertaking in-depth studies into PEVs biosynthesis and subsequently gaining a better understanding of their biological role in general.

show abstract

Section: Historical Background Of Pevsmentioning

confidence: 99%

Understanding the biosynthesis of platelets‐derived extracellular vesicles

Antwi‐Baffour

Adjei

Aryeh

et al. 2015

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…EVs play significant roles in genetic transfer, cytokine release, angiogenesis, transfer of cell receptors, and proteinase release (Kastelowitz and Yin, 2014). Under activation, growth, apoptosis, senescence, shearing stress, oxidative stress and injury, cells release excessive amount of EVs (Antwi-Baffour et al, 2013A, Antwi-Baffour et al, 2013B).…”

Section: Introductionmentioning

confidence: 99%

“…Oxi-Ery and EDNVs are engulfed by macrophages and smooth muscle cells resulted in foam cells formation, and this induced endothelial dysfunction and enhanced atherosclerotic process (Blum, 2009, Tziakas et al, 2010). An increase in EVs release was observed in hypertension, thrombocytopenia, multiple sclerosis, sickle cell anemia, diabetes, and atherosclerosis (Antwi-Baffour et al, 2013A, Antwi-Baffour et al, 2013B).…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte nanovesicles: Biogenesis, biological roles and therapeutic approach

Harisa

Badran

Alanazi

2017

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Nanovesicles (NVs) represent a novel transporter for cell signals to modify functions of target cells. Therefore, NVs play many roles in both physiological and pathological processes. This report highlights biogenesis, composition and biological roles of erythrocytes derived nanovesicles (EDNVs). Furthermore, we address utilization of EDNVs as novel drug delivery cargo as well as therapeutic target. EDNVs are lipid bilayer vesicles rich in phospholipids, proteins, lipid raft, and hemoglobin. In vivo EDNVs biogenesis is triggered by an increase of intracellular calcium levels, ATP depletion and under effect of oxidative stress conditions. However, in vitro production of EDNVs can be achieved via hypotonic treatment and extrusion of erythrocyte. NVs can be used as biomarkers for diagnosis, monitoring of therapy and drug delivery system. Many therapeutic agents are suggested to decrease NVs biogenesis.

show abstract

“…PMVs have again, been implicated in the process of remarkable anti-tumor reversal effect in cancer, tumor immune suppression, metastasis, tumor-stroma interactions and angiogenesis along with having a primary role in tissue regeneration [ 29 ]. Their levels have also been seen to be raised in thalassaemia and sickle cell diseases [ 11 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although increased PMVs, compared to healthy controls, have been associated with increased severity of diseases such as β-thallasaemia and Sickle Cell [ 11 , 19 ], there is only evidence to support a circumstantial association at this stage as many studies are only quantitative and does not look much into the specific role of PMVs in disease states and their contribution to pathogenesis of the diseases [ 11 , 30 ]. Hopefully, more experiments that focus on the function of PMVs in disease states will emerge in the future to give concrete evidence of the role PMVs play in diseases.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterisation of plasma membrane-derived vesicles

Antwi‐Baffour

2015

J Biomed Sci

View full text Add to dashboard Cite

Plasma membrane-derived vesicles (PMVs) are released into circulation in response to normal and stress/pathogenic conditions. They are of tremendous significance for the prediction, diagnosis, and observation of the therapeutic success of many diseases. Knowledge of their molecular characteristics and therefore functional properties would contribute to a better understanding of the pathological mechanisms leading to various diseases in which their levels are raised. The review aims at outlining and discussing the molecular characteristics of PMVs in order to bring to the fore some aspects/characteristics of PMVs that will assist the scientific community to properly understand the role of PMVs in various physiological and pathological processes. The review covers PMVs characterisation and discusses how distinct they are from exosomes and endosomes. Also, methods of PMVs analysis, importance of proper PMV level estimation/characterisation, PMVs and their constituents as well as their therapeutic significance are discussed. The review concludes by drawing attention to the importance of further study into the functions of the characteristics discussed which will lead to understanding the general role of PMVs both in health and in disease states.

show abstract

Plasma Membrane-derived Vesicles (PMVs) in G6PD Deficient Patients

Cited by 4 publications

References 12 publications

Understanding the biosynthesis of platelets‐derived extracellular vesicles

Understanding the biosynthesis of platelets‐derived extracellular vesicles

Erythrocyte nanovesicles: Biogenesis, biological roles and therapeutic approach

Molecular characterisation of plasma membrane-derived vesicles

Contact Info

Product

Resources

About