2001
DOI: 10.1210/edrv.22.4.0435
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Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability

Abstract: Although it was originally believed that thyroid hormones enter target cells by passive diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes. Two stereospecific binding sites for each T4 and T3 have been detected in cell membranes and on intact cells from humans and other species. The apparent Michaelis-Menten values of the high-affinity, low-capacity binding sites for T4 and T3 are in the nanomolar range, whereas the apparent Michaelis- Menten values of the low-affinity, h… Show more

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Cited by 318 publications
(219 citation statements)
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References 233 publications
(255 reference statements)
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“…Raman spectra between 100 and 4000 cm 1 were recorded with a Bio-Rad FT Raman spectrometer (4 cm 1 resolution, 1064 nm excitation) using a 180°backscattering geometry. 11 The solid pure hormones were deposited in quartz tubes of 0.25 cm inner diameter.…”
Section: Methodsmentioning
confidence: 99%
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“…Raman spectra between 100 and 4000 cm 1 were recorded with a Bio-Rad FT Raman spectrometer (4 cm 1 resolution, 1064 nm excitation) using a 180°backscattering geometry. 11 The solid pure hormones were deposited in quartz tubes of 0.25 cm inner diameter.…”
Section: Methodsmentioning
confidence: 99%
“…For T2 the B3LYP/SDD calculations with the COOH and NH 2 groups gauche to the˛ring yield an energy that is higher by 7.61 kJ mol 1 than the structure with the COOH group in an anti conformation. The optimization of such a configuration of T3 failed, whereas a stable structure was reached for T4 with an energy that is higher by 12.6 kJ mol 1 .…”
Section: Structures Of the Thyroninesmentioning
confidence: 99%
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