Plasma metabolomic analysis reveals the metabolic characteristics and potential diagnostic biomarkers of spinal tuberculosis

Wang, Chaoran; Lou, Caili; Yang, Zongqiang; Shi, Jiandang; Niu, Ningkui

doi:10.1016/j.heliyon.2024.e27940

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e27940

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Plasma metabolomic analysis reveals the metabolic characteristics and potential diagnostic biomarkers of spinal tuberculosis

Chaoran Wang,

Caili Lou,

Zongqiang Yang

et al.

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Cited by 2 publications

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Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery

Titkare,

Chaturvedi,

Borah

et al. 2024

Biomedical Chromatography

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Mass spectrometry (MS) plays a crucial role in metabolomics, especially in the discovery of disease biomarkers. This review outlines strategies for identifying metabolites, emphasizing precise and detailed use of MS techniques. It explores various methods for quantification, discusses challenges encountered, and examines recent breakthroughs in biomarker discovery. In the field of diagnostics, MS has revolutionized approaches by enabling a deeper understanding of tissue‐specific metabolic changes associated with disease. The reliability of results is ensured through robust experimental design and stringent system suitability criteria. In the past, data quality, standardization, and reproducibility were often overlooked despite their significant impact on MS‐based metabolomics. Progress in this field heavily depends on continuous training and education. The review also highlights the emergence of innovative MS technologies and methodologies. MS has the potential to transform our understanding of metabolic landscapes, which is crucial for disease biomarker discovery. This article serves as an invaluable resource for researchers in metabolomics, presenting fresh perspectives and advancements that propels the field forward.

show abstract

Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery

Titkare,

Chaturvedi,

Borah

et al. 2024

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

Integrating pathogen- and host-derived blood biomarkers for enhanced tuberculosis diagnosis: a comprehensive review

Li,

Hu,

Wang

et al. 2024

Front. Immunol.

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This review explores the evolving landscape of blood biomarkers in the diagnosis of tuberculosis (TB), focusing on biomarkers derived both from the pathogen and the host. These biomarkers provide critical insights that can improve diagnostic accuracy and timeliness, essential for effective TB management. The document highlights recent advancements in molecular techniques that have enhanced the detection and characterization of specific biomarkers. It also discusses the integration of these biomarkers into clinical practice, emphasizing their potential to revolutionize TB diagnostics by enabling more precise detection and monitoring of the disease progression. Challenges such as variability in biomarker expression and the need for standardized validation processes are addressed to ensure reliability across different populations and settings. The review calls for further research to refine these biomarkers and fully harness their potential in the fight against TB, suggesting a multidisciplinary approach to overcome existing barriers and optimize diagnostic strategies. This comprehensive analysis underscores the significance of blood biomarkers as invaluable tools in the global effort to control and eliminate TB.

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Plasma metabolomic analysis reveals the metabolic characteristics and potential diagnostic biomarkers of spinal tuberculosis

Cited by 2 publications

References 63 publications

Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery

Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery

Integrating pathogen- and host-derived blood biomarkers for enhanced tuberculosis diagnosis: a comprehensive review

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