Plasma metagenomics reveals regional variations of emerging and re-emerging pathogens in Chinese blood donors with an emphasis on human parvovirus B19

Mengyi, Zhao; Yuhui, Li; Zhan, Gao; Anqing, Liu; Yujia, Li; Shilin, Li; Lei, Gao; Yue, Lan; Mei, Huang; Jianhua, Wan; Weilan, He; Wei, Mao; Jie, Cai; Jingyu, Zhou; Yijing, Yin; Yanli, Guo; Qiulei, Zhong; Yang, Huang; Limin, Chen; Zhenxin, Fan; Miao, He

doi:10.1016/j.onehlt.2023.100602

Cited by 6 publications

(3 citation statements)

References 45 publications

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Section: Discussionmentioning

confidence: 99%

“…For mild patients, Burkholderia and Paraburkholderia were identified in nasopharyngeal swabs and B. coprocola and R. bicirculans in stool samples. Although the information regarding the first two species in humans is limited, a few studies have reported their presence in the commensal human microbiota [77, 78]. Contrarily, B. coprocola and R. bicirculans have been found in both healthy and COVID-19 patients [79] although the abundance of R. bicirculans was reduced in infected subjects [80].…”

Section: Discussionmentioning

confidence: 99%

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The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

Martin-Castaño,

Diez-Echave,

García-García

et al. 2024

Preprint

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Background: Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity but no specific determinants of infection outcome have been identified yet, maybe due the complex pathogenic mechanisms. The microbiota could play a key role in the infection and in the progression and outcome of the disease. Hence, SARS-CoV-2 infection has been associated with nasopharyngeal and gut dysbiosis and higher abundance of opportunistic pathogens. Methods: To identify new prognostic markers for the disease, a multicenter prospective observational cohort study was carried out in COVID-19 patients that were divided in three cohorts according to their symptomatology: mild (n=24), moderate (n=51) and severe/critical (n=31). Faecal and nasopharyngeal samples were taken and the microbiota was analysed. Results: Microbiota composition could be associated with the severity of the symptoms and the linear discriminant analysis identified the generaMycoplasmaandPrevotellaas severity biomarkers in nasopharyngeal samples, andAllistipes,EnterococcusandEscherichiain faecal samples. Moreover,M. salivariumwas defined as a unique microorganism in COVID-19 patients' nasopharyngeal microbiota whileP. biviaandP. timonensiswere defined in faecal microbiota. A connection between faecal and nasopharyngeal microbiota in COVID-19 patients was also identified as a strong positive correlation betweenP. timonensis(faeces) towardsP. dentalisandM. salivarium(nasopharyngeal) was found in critically ill patients. Conclusions: This ratio could be used as a novel prognostic biomarker for severe COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

Martin-Castaño,

Diez-Echave,

García-García

et al. 2024

Preprint

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“…Notably, sequences from China classified as 1a formed a distinct cluster within this Israeli group. This outcome may be influenced by the extensive genetic analysis of B19V recently conducted in China that also has a high prevalence of the 1a subtype [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19 Outbreak in Israel: Retrospective Molecular Analysis from 2010 to 2023

Mor,

Wax,

Arami

et al. 2024

Viruses

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This study presents an analysis of the epidemiological trends of parvovirus B19 (B19V) in Israel from 2010 to 2023, with particular emphasis on the outbreak in 2023. The analysis utilized molecular diagnostic data from individual patients obtained at the Central Virology Laboratory. Between 2010 and 2022, 8.5% of PCR-tested samples were positive for B19V, whereas in 2023, this percentage surged to 31% of PCR-tested samples. Throughout the study period, annual cycles consistently peaked in early spring/summer, with the most recent prominent outbreak occurring in 2016. Predominantly, diagnoses were made in children and women aged 20–39. Despite the notable surge in 2023, over 80% of positive cases continued to be observed in children and young women, with a decrease in cases during winter months. Furthermore, genotype 1a of the virus remained the predominant strain circulating during the outbreak. In light of these circumstances, consideration should be given to implementing screening measures, particularly among high-risk groups such as pregnant women.

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The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

Martin-Castaño,

Diez-Echave,

García-García

et al. 2024

Preprint

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity but no specific determinants of infection outcome have been identified yet, maybe due the complex pathogenic mechanisms. The microbiota could play a key role in the infection and in the progression and outcome of the disease. Hence, SARS-CoV-2 infection has been associated with nasopharyngeal and gut dysbiosis and higher abundance of opportunistic pathogens. To identify new prognostic markers for the disease, a multicenter prospective observational cohort study was carried out in COVID-19 patients that were divided in three cohorts according to their symptomatology: mild (n=24), moderate (n=51) and severe/critical (n=31). Faecal and nasopharyngeal samples were taken and the microbiota was analysed. Microbiota composition could be associated with the severity of the symptoms and the linear discriminant analysis identified the genera Mycoplasma and Prevotella as severity biomarkers in nasopharyngeal samples, and Allistipes , Enterococcus and Escherichia in faecal samples. Moreover, M. salivarium was defined as a unique microorganism in COVID-19 patients’ nasopharyngeal microbiota while P. bivia and P. timonensis were defined in faecal microbiota. A connection between faecal and nasopharyngeal microbiota in COVID-19 patients was also identified as a strong positive correlation between P. timonensis (faeces) towards P. dentalis and M. salivarium (nasopharyngeal) was found in critically ill patients. This ratio could be used as a novel prognostic biomarker for severe COVID-19 patients.

show abstract

Plasma metagenomics reveals regional variations of emerging and re-emerging pathogens in Chinese blood donors with an emphasis on human parvovirus B19

Cited by 6 publications

References 45 publications

The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

Parvovirus B19 Outbreak in Israel: Retrospective Molecular Analysis from 2010 to 2023

The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

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