Plasma Mineral Content in Type-2 Diabetic Patients and Their Association with the Metabolic Syndrome

Abstract

Background: Metabolic syndrome is a clinical disorder that is becoming more prevalent in Spain. The syndrome encompasses a set of metabolic disorders such as type-2 diabetes mellitus, hypertension, dyslipidemia, and obesity, which may be associated with variations in serum levels and poor delivery of certain mineral elements. Methods: This study attempted to ascertain whether metabolic syndrome might be linked to alterations in serum levels of the mineral elements magnesium, copper, zinc, chromium, and nickel in a population of 92 diabetic subjects, some suffering from certain conditions associated with the metabolic syndrome, and 72 control subjects (Hospital Príncipe de Asturias, Alcalá de Henares, Spain). Results: The results indicated that as a group the alterations implicated in metabolic syndrome were indeed associated with variations in blood levels of the mineral elements considered, though statistically significant differences were recorded only in the case of copper. Still, trends in mineral levels for each of the separate components contributing to the syndrome tended to increase. Conclusion: Metabolic complications appear to be associated with alterations in the levels of some minerals, especially copper.

Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients

“…In the present study, the correlation of essential and nonessential elements in scalp hair of DM-2 patients of both genders related to non-diabetic subjects belonging to Pakistan and Ireland was carried out. The results presented in Table 4 for healthy subjects and DM-2 patients confirm higher levels of Cd and Pb while lower values of Mg, Mn, Zn and Cr are associated with diabetes, which are consistent with other studies [31][32][33][34]. The results showed that the level of Mg was significantly lower in scalp hair samples of DM-2 patients as related to referents (P <0.001 ).…”

Interactions Between Zinc Transporter-8 Gene (SLC30A8) and Plasma Zinc Concentrations for Impaired Glucose Regulation and Type 2 Diabetes

“…At the same time, zinc is a critical component of the catalytic site of .300 enzymes, implicated in synthesis, storage, and secretion of insulin, as well as being a signaling molecule after insulin secretion (5). Some studies have investigated possible associations between zinc status and diabetes; most reported that patients with diabetes had lower serum/plasma zinc levels (6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

“…Transition metal ions strongly bind to phospholipids and alter the liposome bilayer and increase their susceptibility to lipid peroxidation (Oteiza et al 2004). Both the essentiality and toxicity of these metals ions in the pathogenesis of diabetes mellitus and diabetic complications are often reported (Walter et al 1991;Aguilar et al 2007;Zheng et al 2008). Transition metals ions also play a role in protein glycation induced by hyperglycemia.…”