Plasma MIR-212-3p as a biomarker for acute right heart failure with pulmonary artery hypertension

Yang, Yue; Li, Renhua; Cao, Yanan; Dai, Shenyu; Luo, Sumei; Guo, Qulian; Wang, E

doi:10.21037/atm-20-1653a

Cited by 7 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR‐212‐3p was found to be one of the highly expressed tissue specific miRNAs significantly correlated with cardiovascular risk factors in patients with coronary artery disease (Neiburga et al., 2021 ). Reduced miR‐212‐3p levels have been reported as a biomarker for pulmonary artery hypertension in patients with acute right heart failure (Yang et al., 2020 ). Together with our findings, these evidences support the possibility that evaluation of miR‐212‐3p fluctuations during the process of disease development could be a novel diagnostic approach to estimate the health risk after radiation exposure.…”

Section: Discussionmentioning

confidence: 99%

The miR‐126‐5p and miR‐212‐3p in the extracellular vesicles activate monocytes in the early stage of radiation‐induced vascular inflammation implicated in atherosclerosis

Choi

Kim

Lee

et al. 2023

J of Extracellular Vesicle

View full text Add to dashboard Cite

People exposed to radiation in cancer therapy and nuclear accidents are at increased risk of cardiovascular outcomes in long-term survivors. Extracellular vesicles (EVs) are involved in radiation-induced endothelial dysfunction, but their role in the early stage of vascular inflammation after radiation exposure remains to be fully understood. Herein, we demonstrate that endothelial cell-derived EVs containing miRNAs initiate monocyte activation in radiation-induced vascular inflammation. In vitro coculture and in vivo experimental data showed that endothelial EVs can be sensitively increased by radiation exposure in a dose-dependent manner, and stimulate monocytes releasing monocytic EVs and adhesion to endothelial cells together with an increase in the expression of genes encoding specific ligands for cell-cell interaction. Small RNA sequencing and transfection using mimics and inhibitors explained that miR-126-5p and miR-212-3p enriched in endothelial EVs initiate vascular inflammation by monocyte activation after radiation exposure. Moreover, miR-126-5p could be detected in the circulating endothelial EVs of radiation-induced atherosclerosis model mice, which was found to be tightly correlated with the atherogenic index of plasma. In summary, our study showed that miR-126-5p and miR-212-3p present in the endothelial EVs mediate the inflammatory signals to activate monocytes in radiation-induced vascular injury. A better understanding of the circulating endothelial EVs content can promote their use as diagnostic and prognostic biomarkers for atherosclerosis after radiation exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

The miR‐126‐5p and miR‐212‐3p in the extracellular vesicles activate monocytes in the early stage of radiation‐induced vascular inflammation implicated in atherosclerosis

Choi

Kim

Lee

et al. 2023

J of Extracellular Vesicle

View full text Add to dashboard Cite

show abstract

“…Exposure to glucose increased miR-212-3p expression in rat islets [ 87 ]. In a human cohort miR-212-3p was identified as potential biomarker for acute right heart failure with pulmonary artery hypertension [ 90 ]. Obesity is a chronic condition that can subsequently impact function of the right ventricle and pulmonary arterial pressure.…”

Section: Discussionmentioning

confidence: 99%

Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease

et al. 2021

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from Arteria mammaria interna (IMA) from 192 coronary artery disease (CAD) patients undergoing coronary artery bypass grafting (CABG) were analyzed. The aims of the study were 1) to establish a reference atlas which can be utilized for identification of novel diagnostic biomarkers and potential therapeutic targets, and 2) to relate these miRs to cardiovascular risk factors. Overall, 393 individual miRs showed sufficient expression levels and passed quality control for further analysis. We identified 17 miRs–miR-10b-3p, miR-10-5p, miR-17-3p, miR-21-5p, miR-151a-5p, miR-181a-5p, miR-185-5p, miR-194-5p, miR-199a-3p, miR-199b-3p, miR-212-3p, miR-363-3p, miR-548d-5p, miR-744-5p, miR-3117-3p, miR-5683 and miR-5701–significantly correlated with cardiovascular risk factors (correlation coefficient >0.2 in both directions, p-value (p < 0.006, false discovery rate (FDR) <0.05). Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. In addition, we found that miR-629-5p and miR-98-5p were significantly correlated with acute myocardial infarction. We provide a first atlas of miR profiles in IMA samples from CAD patients. In perspective, these miRs might play an important role in improved risk assessment, mechanistic disease understanding and local therapy of CAD.

show abstract

“…For example, circulating miR-19b-3p may be a new prognostic parameter for AHF, and high levels of circulating miR-19b-3p may imply ventricular hypertrophy in AHF patients [ 15 ]. In addition, plasma miR-212-3p can be used as a biomarker for acute right HF with pulmonary hypertension [ 16 ]. Serum miR-30d levels are markedly reduced in AHF patients and can be used to predict survival in AHF patients [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of plasma miR-106a-5p levels in patients with acute heart failure

Fei,

Li,

et al. 2024

J Cardiothorac Surg

View full text Add to dashboard Cite

Background It is essential to find reliable biomarkers for early diagnosis and prognosis of acute heart failure (AHF) for its mitigation. Currently, increasing attention is paid to the role of microRNAs (miRNAs/miRs) as diagnostic or prognostic markers for cardiovascular diseases. Since plasma miR-106a-5p has been observed to be downregulated in AHF, its value in the diagnosis and prognostic assessment of AHF deserves further exploration. Accordingly, this study analyzed the diagnostic and prognostic value of plasma miR-106a-5p in AHF patients. Methods Prospectively, this study included 127 AHF patients who met the 2021 European Society of Cardiology Guidelines and 127 control individuals. Plasma miR-106a-5p levels were determined with RT-qPCR. Spearman correlation analysis was performed to evaluate the correlation of plasma miR-106a-5p levels with NT-proBNP and hs-CRP levels in AHF patients. All AHF patients were followed up for 1 year and allocated into poor and good prognosis groups, and plasma miR-106a-5p levels were compared. The diagnostic and prognostic value of plasma miR-106a-5p for AHF was assessed with a receiver-operating characteristic curve. Results Plasma miR-106a-5p was lowly expressed in AHF patients versus controls (0.53 ± 0.26 vs. 1.09 ± 0.46) and showed significant negative correlations with NT-proBNP and hs-CRP levels. Plasma miR-106a-5p level < 0.655 could assist in AHF diagnosis. Plasma miR-106a-5p levels were markedly lower in poor-prognosis AHF patients than in good-prognosis patients. Plasma miR-106a-5p level < 0.544 could assist in predicting poor prognosis in AHF patients. Conclusion Plasma miR-106a-5p is downregulated in AHF patients and could assist in diagnosis and poor prognosis prediction of AHF.

show abstract

Plasma MIR-212-3p as a biomarker for acute right heart failure with pulmonary artery hypertension

Cited by 7 publications

References 36 publications

The miR‐126‐5p and miR‐212‐3p in the extracellular vesicles activate monocytes in the early stage of radiation‐induced vascular inflammation implicated in atherosclerosis

The miR‐126‐5p and miR‐212‐3p in the extracellular vesicles activate monocytes in the early stage of radiation‐induced vascular inflammation implicated in atherosclerosis

Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease

Diagnostic and prognostic value of plasma miR-106a-5p levels in patients with acute heart failure

Contact Info

Product

Resources

About