Plasma Myoglobin in the Early Diagnosis of Acute Myocardial Infarction

Abstract

Summary: Serum and plasma myoglobin and creatine kinase-MB catalytic activity were analysed in 157 patients admitted within 2 hours of the onset of ehest pain (58 were retrospectively recognized s acute myocardial infarction).Serum and plasma values were highly correlated for both myoglobin and creatine kinase-MB.Plasma myoglobin appared to be more sensitive than creatine kinase-MB for the early diagnosis of acute myocardial infarction; using a cut-off value of 100 μ §/1, 90% of acute myocardial infarction cases were correctly recognized by plasma myoglobin 6 hours after the onset of ehest pain, with a diagnostic specificity of 100% for non-acute myocardial infarction ehest pain subjects. Plasma creatine kinase-MB showed a diagnostic sensitivity of 62% and a diagnostic specificity of 95% in the same group of patients.We suggest the inclusion of the plasma myoglobin immunonephelometric assay together with plasma creatine kinase-MB activity analysis in protocols for the early diagnosis of acute myocardial infarction.

Novel biochemical markers in suspected acute coronary syndrome: systematic review and critical appraisal

“…An overview of the 30 relevant articles on myoglobin is outlined in table 3 15 18 20 24 28 32–44 48–59. All studies but one were performed in the correct study domain and all studies had the relevant outcome AMI (WHO n=23, Joint ESC/ACC consensus 2000 n=5) or ACS (n=2).…”

Protein-responsive polymers for point-of-care detection of cardiac biomarker

“…Thus, this new concept of electropolymerization for imprinting a protein cardiac biomarker is here described, using Myo as target protein. Myo is a heme protein responsible for the transport of oxygen within cardiac and skeletal muscle cells [35,36] that is released early in the blood in the course of cardiac muscle damage. The measurement of Myo levels within the first few hours after symptom onset in acute events is crucial to diagnosis of cardiac injury.…”

“…The measurement of Myo levels within the first few hours after symptom onset in acute events is crucial to diagnosis of cardiac injury. Typical concentrations range from 95 to 472 µg/L [35,[37][38][39].…”

Detection of cardiac biomarker proteins using a disposable based on a molecularly imprinted polymer grafted onto graphite

“…Although Myo levels should not be used as the sole biomarker for the diagnosis of ACS, a normal Myo concentration within 2 h after presentation may exclude AMI [4,6]. Myo cut-off levels range from 100 to 200 ng·mL −1 [7,8], reaching levels of 420-2000 ng· mL −1 in serum [9] and 450 ng· mL −1 in the urine [10]. Screening Myo in an emergency context is therefore important, and a suitable point-of-care (POC) assay would result in a reduced time to diagnosis and treatment [11].…”