Plasma Nesfatin-1 and Insulin Resistance Changes Immediately After Circuit-Resistance Exercise and During Recovery Periods in Healthy Men

Abstract

Objectives: Resistance exercise is an effective method for weight control programs, and it might be useful to understand its influence on acute body energy hemostasis changes. Therefore, the present study aimed to examine the response of nesfatin-1 and insulin resistance (IR) to acute circuit resistance exercise and their changes during recovery periods. Methods: Twelve participants (age: 22.1 ± 2.1 y, height: 176.2 ± 6.5 cm and weight: 69.0 ± 8.2 kg) attended voluntary in this research. After performing one maximal repetition (1-RM) test in a separate session for each participant, they completed circuit resistance exercise trial at 50% of 1-RM intensity. Exercise session consisted of 3 circuit of 7 exercises with 2 minutes and 30 seconds rest between circuits and exercises, respectively. All participants attended a control session with 1 week interval. After 8-10 hours fasting blood samples were obtained from antecubital vein before exercise, after exercise, 1-hour and 24-hour after recovery from the last exercise session, and at the same times of the rest session. Nesfatin-1, insulin and glucose were measured from plasma samples. All data series were analyzed with repeated measure ANOVA (2 × 4). Results: Data analysis revealed significant increases in nesfatin-1 and IR in response to acute circuit resistance exercise (P < 0.05), but no significant changes were observed in nesfatin-1 and IR at 1-hour recovery period and 24-hour after recovery (P > 0.05). Conclusions: The present study revealed that nesfatin-1 significantly increased in response to circuit resistance exercise, which suggests that plasma nesfatin-1 may have an influential role in short-term anorexia and insulin secretion immediately after exercise.

Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review

“…From the 36 included studies, 23 examined humans 41–63 with 13 examining animal models 64–76 . Studies investigated the effects of chronic exercise training 41–51,63 and acute exercise 48,52–62 in humans. One study compared the effect of chronic and acute exercise 48 .…”

“…The exercise session consisted of three circuits of seven exercises with 2 min and 30 s rest between circuits and exercises. The results showed that acute circuit resistance exercise increased Nesfatin‐1 62 …”

“…Adipose tissue, 11 the central nervous system, 1 and the peripheral nervous system 77 synthesize Nesfatin‐1, which is then released into the bloodstream. Numerous studies have examined the influence of exercise on Nesfatin‐1 concentration in a wide range of exercise protocols in both humans 41–63 and animals 64–76 . Having examined the body of available literature, the key finding is that Nesfatin‐1 concentration is induced by numerous modes of exercise.…”

“…The purpose of conducting this review is to assess the existing research evidence regarding the impact of exercise on Nucleobindin-2 (NUCB2) gene expression and Nesfatin-From the 36 included studies, 23 examined humans with 13 examining animal models. [64][65][66][67][68][69][70][71][72][73][74][75][76] Studies investigated the effects of chronic exercise training [41][42][43][44][45][46][47][48][49][50][51]63 and acute exercise 48,[52][53][54][55][56][57][58][59][60][61][62] in humans.…”

“…The results showed that acute circuit resistance exercise increased Nesfatin-1. 62 Yazıcı experimented with sports such as athletics, boxing, and taekwondo to determine whether competitive sports affect Nesfatin-1 concentration. Athletics, boxing, and taekwondo athletes had significantly higher Nesfatin-1 concentration after anaerobic competition exercise.…”