Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients1

Thompson, Larry O.; Skrabal, Christian; Loebe, Matthias; Lafuente, Javier; Roberts, Rick R.; Akgül, Ahmet; Jones, Vonne; Bruckner, Brian A.; Thohan, Vinay; Noon, George P.; Youker, Keith A.

doi:10.1016/j.jss.2004.05.013

Cited by 57 publications

(38 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5,7,12,31,50,51 Ejec ti on frac ti on is con si dered as a po wer ful in di ca tor of ope ra ti ve out co mes by most of the sur ge ons, and re cent stu di es in vesti ga ting pre dic ti ve va lu e of BNP, Eu ros co re and LVEF sho wed si mi lar re sults. 36,40 The uti lity of nat ri u re tic pep ti des le vels to op ti mi ze ope ra ti on ti me af ter myo car di al in farc ti on sho uld be in ves ti ga ted.…”

Section: Discussionmentioning

confidence: 99%

“…1,5,6,[10][11][12][13][14][15][16][17][18] Cur rently, BNP and NT-proBNP are rou ti nely used as di ag nos tic pa ra me ters in many cli nics' emer gency and in ten si ve ca re units.Re mode ling des cri bes struc tu ral chan ges of he art af ter myo car di al in farc ti on, and can be di vi ded to early and la te pha ses. Early pha se oc curs wit hin the first thre e days fol lo wing myo car di al in farc ti on (MI), and the la te pha se oc curs af ter the third day of MI.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Amino Terminal Pro-B-Type Natriuretic Peptide and Late Left Ventricular Reverse Remodeling in Coronary Artery Bypass Grafting Patients with Low Ejection Fraction

Hatemi¹,

Gürsoy²,

Işiksungur³

et al. 2011

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Left ven tri cu lar re mo de ling ac ce le ra tes the co ur se of car di ac fa i lu re by aggra va ting ven tri cu lar dysfunc ti on fol lo wing myo car di al in farc ti on. Thus, pre dic ti on and pre ven tion of left ven tri cu lar re mo de ling is cru ci al. The aim of this study was to eva lu a te the pre dic ti ve va lu e of pe ri o pe ra ti ve plas ma NT-proBNP le vels for pos to pe ra ti ve left ven tri cu lar re ver se re mo deling and ejec ti on frac ti on in pa ti ents who un der went co ro nary ar tery bypass graf ting. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Forty pa ti ents with myo car di al in farc ti on inprevious thre e months we re en rol led in the study. All pa ti ents with mo de ra te left ven tri cu lar dysfunc ti on (EF ≤40%) un der went on pump coro nary ar tery bypass graf ting (CABG) ope ra ti on. Pa ti ents' pre o pe ra ti ve left ven tric le vo lu mes and in de xes, ejec ti on frac ti ons, and NT-proBNP le vels we re com pa red to the pos to pe ra ti ve va lu es. R Re e--s su ul lt ts s: : Pre o pe ra ti ve NT-proBNP le vels we re sig ni fi cantly re la ted to pre o pe ra ti ve and pos to pe ra ti ve ejec ti on frac ti ons, and pos to pe ra ti ve left ven tri cu lar re ver se re mo de ling (p= 0.037, p= 0.033, p= 0.014, res pec ti vely). C Co on nc c l lu u s si i o on n: : The pre o pe ra ti ve N-ter mi nal proBNP may help to as sess the pos to pe ra ti ve ejec ti on frac ti on and ven tri cu lar re mo de ling. Ami no ter mi nal proBNP is a sa fe, ava i lable and ef fec ti ve to ol to pre dict the pos to pe ra ti ve func ti o nal and struc tu ral chan ges of the left ven tric le. K Ke ey y W Wo or rd ds s: : Pro-bra in nat ri u re tic pep ti de (1-76); ven tri cu lar re mo de ling; co ro nary ar tery bypass; ec ho car di og raphy; stro ke vo lu me Ö ÖZ ZE ET T A Am ma aç ç: : İnfark tüs son ra sı dö nem de ki sol ven tri kü lün ye ni den şekil len me si (re mo del ling) kalp yet mez li ği ne gö tü ren kö tü prog noz için güç lü bir gös ter ge dir. Bu ça lış ma nın ama cı pe ri o pera tif plaz ma NT-proBNP dü ze yi nin cer ra hi re vas kü la ri zas yon son ra sı sol ven tri kül re vers re model lin gi ve ejek si yon frak si yo nu yö nün den pre dik tif de ğe ri ni in ce le mek tir. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Son üç ay için de mi yo kard en fark tü sü ge çi ren ve or ta dü zey de sol ven tri kül (LV) dis fonk si yo nu olan 40 has ta ça lış ma ya alın dı. Bü tün has ta la ra pom pa yar dım lı ko ro ner ar ter bay pas greft le me (CABG) ope ras yo nu ya pıl mış tı. Has ta lar da pre o pe ra tif sol ven tri kül ha cim le ri ve in deks le ri, ejeksi yon frak si yon la rı ve NT-proBNP dü zey le ri pos to pe ra tif de ğer ler le kar şı laş tı rıl dı. B Bu ul l g gu u l la ar r: : Preo pe ra tif NT-ProBNP dü zey le ri pre o pe ra tif ve pos to pe ra tif ejek si yon frak si yon la rı ve pos to pe ra tif sol ven tri kül re vers re mo del ling ile (sı ra sıy la p= 0.037, p= 0.033, p=...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Amino Terminal Pro-B-Type Natriuretic Peptide and Late Left Ventricular Reverse Remodeling in Coronary Artery Bypass Grafting Patients with Low Ejection Fraction

Hatemi¹,

Gürsoy²,

Işiksungur³

et al. 2011

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

show abstract

“…Type 1 collagen, type 1: type 3 collagen ratio, collagen cross linking and fibrosis have been shown to be elevated in a variety of clinical as well as experimental disease states (Avendano et al 1999;Badenhorst et al 2003;Marijianowski et al 1995;Mukherjee and Sen 1991;Porter and Turner 2009;Woodiwiss et al 2001). Reports of LVAD-induced ECM changes have been conflicting, with some revealing increased myocardial fibrosis and ECM volume following unloading (Klotz, S. et al 2005b;Li et al 2001;Matsumiya et al 2005;Saito et al 2010), and others showing a reduction (Akgul et al 2004;Bruckner et al 2001;Maybaum et al 2007;Thohan et al 2005;Thompson et al 2005). Bruggink et al demonstrated a biphasic response with initial expansion of ECM and then a subsequent regression with prolonged MU (Bruggink et al 2006).…”

Section: Extracellular Matrixmentioning

confidence: 99%

“…LVAD support is known to decrease plasma adrenaline, noradrenaline (NA), renin, aldosterone and vasopressin (Klotz et al 2009) as well as Atrial and B-type natriuretic peptide plasma levels (Thompson et al 2005), myocardial gene (Kuhn et al 2004) and protein (Wohlschlaeger et al 2008) expression. Occasional correlation between measured biomarkers and functional improvement raises the possibility of the potential use of such markers in guiding therapy and prediction of recovery (Thompson et al 2005).…”

Section: Neurohumoral Effectsmentioning

confidence: 99%

Myocardial Recovery Following Left Ventricular Assist Device Therapy

Navaratnarajah¹,

Ibrahim²,

Yacoub³

et al. 2011

New Aspects of Ventricular Assist Devices

View full text Add to dashboard Cite

“…Wei C. et al обнаружили отрицательную корреляцию уровня ЭТ-1 с ФВ ЛЖ и СИ, а также положительную корреляцию пептида с индексированным КДО ЛЖ [20]. Сходные данные были получены Thompson L. O. et al при определении уровня Big-ЭТ у больных с ХСН 3-4 ФК [29]. В то же время, по данным Ludka O. et al, обсле-довавших 99 пациентов с ХСН различных ФК, обна-ружено наличие зависимости уровня Big-ЭТ только от показателя кардиоторакального индекса [30].…”

unclassified

Endothelines and Cardiovascular Pathology

Alieva¹,

Чиркова²,

Pinchuk³

et al. 2015

Ross. kardiol. ž.

View full text Add to dashboard Cite

Многие исследования последних лет были посвящены изменениям в сис-теме эндотелина, как одному из ключевых звеньев эндотелиальной дис-функции. Активация эндотелиновой системы, маркером которой является повышение уровня эндотелина и его предшественника, наблюдается при многих сердечно-сосудистых заболеваниях. Доказано достоверное повы-шение уровня эндотелина-1 и Big-эндотелина при атеросклерозе, стено-кардии, остром инфаркте миокарда, гипертонической болезни и легочной гипертензии. Many studies of the last years were concerned the changes in endotheline system as one of the chains in endothelial dysfunction. Activation of endotheline system, which is marked by the increase of endotheline level and its predecessor, is common for many cardiovascular diseases. The significant increase of endotheline-1 and Big-endotheline is shown in atherosclerosis, angina, acute myocardial infarction, hypertensive disease and pulmonary hypertension. Российский

show abstract

Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients1

Cited by 57 publications

References 58 publications

Amino Terminal Pro-B-Type Natriuretic Peptide and Late Left Ventricular Reverse Remodeling in Coronary Artery Bypass Grafting Patients with Low Ejection Fraction

Amino Terminal Pro-B-Type Natriuretic Peptide and Late Left Ventricular Reverse Remodeling in Coronary Artery Bypass Grafting Patients with Low Ejection Fraction

Myocardial Recovery Following Left Ventricular Assist Device Therapy

Endothelines and Cardiovascular Pathology

Contact Info

Product

Resources

About