Plasma Neutrophil Elastase and Elafin Imbalance Is Associated with ARDS Development.

Wang, Z; Chen, F; Zhai, Rihong; Zhang, L; Su, Liang; Lin, Xinhua; Thompson, TB; Dc, Christiani

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3867

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“…Neutrophil degranulation is a key aspect of the response of neutrophils to pathogens (Lacy, 2006), and mice without a functional copy of Elane, which encodes neutrophil elastase, have increased mortality upon sepsis than controls (Belaaouaj et al, 1998). However, excessive levels of circulating neutrophil elastase are also thought to be deleterious, amplifying septic shock (Barbosa da Cruz et al, 2019) and acute respiratory distress syndrome (Wang et al, 2009). Based on our transcriptomic data, we hypothesized that higher expression of Elane in neutrophils could lead to increased circulating levels of neutrophil elastase, both in basal conditions and upon an external immune challenge.…”

Section: Machine-learning Reveals Predictive Features Of Age-related mentioning

confidence: 84%

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

Taylor

Contrepois

et al. 2020

Preprint

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SummaryNeutrophils are the most abundant white blood cells in humans and constitute one of the first lines of defense in the innate immune response. Neutrophils are extremely short-lived cells, which survive less than a day after reaching terminal differentiation. Thus, little is known about how organismal aging, rather than the daily cellular aging process, may impact neutrophil biology. In addition, accumulating evidence suggests that both immunity and organismal aging are sex-dimorphic. Here, we describe a multi-omic resource of mouse primary bone marrow neutrophils from young and old female and male mice, at the transcriptomic, metabolomic and lipidomic levels. Importantly, we identify widespread age-related and sex-dimorphic regulation of ‘omics’ in neutrophils, specifically regulation of chromatin. Using machine-learning, we identify candidate molecular drivers of age-related and sex-dimorphic transcriptional regulation of neutrophils. We leverage our resource to predict increased levels/release of neutrophil elastase in male mice. To date, this dataset represents the largest multi-omics resource for the study of neutrophils across biological sex and ages. This resource identifies molecular states linked to neutrophil characteristics linked to organismal age or sex, which could be targeted to improve immune responses across individuals.

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Section: Machine-learning Reveals Predictive Features Of Age-related mentioning

confidence: 84%

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

Taylor

Contrepois

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Plasma Neutrophil Elastase and Elafin Imbalance Is Associated with ARDS Development.

Cited by 1 publication

References 0 publications

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

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