Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors

Yoon, Young Eun; Cho, Y.I.; Kim, S.Y.; Lee, H.H.; Huh, Kyu Ha; Kim, Y.S.; Han, Woong Kyu

doi:10.1016/j.transproceed.2015.12.094

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…B). sNGAL, as reported previously , was maximal at 7 days postoperatively [mean (SD) 207 (81.2) ng/mL] and stabilised by 1 month postoperatively (Fig. C).…”

Section: Resultssupporting

confidence: 81%

“…Various markers have been evaluated to aid in donor selection or to monitor postoperative renal function, including neutrophil gelatinase‐associated lipoprotein (NGAL), a kidney injury marker . We previously reported that serum NGAL (sNGAL) provided information about kidney injury during the compensatory hyperfiltration period after living‐donor nephrectomy . At 7 days postoperatively, sNGAL was highly predictive of CKD at 6 months postoperatively.…”

Section: Introductionmentioning

confidence: 99%

“…This occurs because sNGAL is produced by other organs, such as the liver, lungs, and bone marrow, as part of a postoperative inflammatory reaction . Moreover, sNGAL tends to respond later or shows less change than serum creatinine (sCr) .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prospective assessment of urinary neutrophil gelatinase‐associated lipoprotein in living kidney donors: toward understanding differences between chronic kidney diseases of surgical and medical origin

Yoon

Lee

et al. 2018

BJU International

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“…B). sNGAL, as reported previously , was maximal at 7 days postoperatively [mean (SD) 207 (81.2) ng/mL] and stabilised by 1 month postoperatively (Fig. C).…”

Section: Resultssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective assessment of urinary neutrophil gelatinase‐associated lipoprotein in living kidney donors: toward understanding differences between chronic kidney diseases of surgical and medical origin

Yoon

Lee

et al. 2018

BJU International

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“…In a recent study by Yoon et al [35], NGAL levels 1 week after donor nephrectomy, but not preoperative NGAL levels, were associated with an eGFR <60 ml/min/1.73 m 2 6 months postoperatively. This supports our hypothesis that increased NGAL levels in kidney donors may be a biomarker for an increased risk of development of CKD.…”

Section: Discussionmentioning

confidence: 97%

Neutrophil Gelatinase-Associated Lipocalin, Fibroblast Growth Factor 23, and Soluble Klotho in Long-Term Kidney Donors

Thorsen¹,

Bleskestad²,

Jonsson

et al. 2016

Nephron Extra

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Background: The best treatment for end-stage renal disease (ESRD) is kidney transplantation. Twenty-seven percent of transplantations in Norway are from living donors. Recent studies have shown an increased risk of ESRD and increased mortality in donors. The aim of this study was to determine if the levels of the new biomarkers neutrophil gelatinase-associated lipocalin (NGAL), soluble Klotho (sKlotho), and fibroblast growth factor 23 (FGF23) are changed in kidney donors with normal kidney function defined as an estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m² compared to patients with chronic kidney disease (CKD) stages 3-5 and healthy controls. Methods: This is a cross-sectional, observational, single-center study including 35 kidney donors with an eGFR ≥60 ml/min/1.73 m² 5 years after donation, 22 patients with CKD stage 3 (eGFR 30-59 ml/min/1.73 m²), 18 patients with CKD stage 4 (eGFR 15-29 ml/min/1.73 m²), 20 patients with CKD stage 5 (eGFR <15 ml/min/1.73 m²), and 35 controls comparing levels of biomarkers in long-term kidney donors with those in CKD patients and healthy controls. Results: The level of log NGAL was significantly higher in donors than in healthy controls (2.02 ± 0.10 vs. 1.89 ± 0.10 ng/ml; p < 0.001), and the level increased with declining kidney function. The log FGF23 level was nonsignificantly higher in donors than in controls, but it significantly increased with declining kidney function. The log sKlotho levels were significantly lower in patients with CKD stages 4 and 5 than in controls, but no difference was revealed between controls and donors. Conclusion: Kidney donors have significantly higher levels of NGAL than healthy controls after a median of 15 years (range 5-38). NGAL could be a valuable diagnostic marker in the future. FGF23 and sKlotho were not significantly different between donors and controls.

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“…This correlation was found to be strongest using plasma NGAL at 1 week post-operatively, but a correlation was found at all time points [30]. …”

Section: Introductionmentioning

confidence: 99%

A comparison of the effects of oral vs. intravenous hydration on subclinical acute kidney injury in living kidney donors: a protocol of a randomised controlled trial

et al. 2017

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BackgroundOptimal treatment for established renal failure is living donor kidney transplantation. However this pathway exposes healthy individuals to significant reduction in nephron mass via major surgical procedure. Laparoscopic donor nephrectomy is now the most common method for live donor transplantation, reducing both donor post-operative pain and recovery time. However this procedure exposes kidneys to additional haemodynamic stresses. It has been suggested that donor hydration—particularly the use of preoperative intravenous fluids—may counteract these stresses, reducing subclinical acute kidney injury and ultimately improving long-term renal function. This may be important in both preservation of donor renal function and recipient graft longevity.Methods/DesignA prospective single-centre single-blinded randomized controlled trial will be carried out to determine the effects of donor preoperative intravenous fluids. The primary outcome is donor subclinical acute kidney injury (defined as plasma NGAL, >153 ng/ml) on day 1 postoperatively. Secondary outcomes include intraoperative haemodynamics, recipient subclinical acute kidney injury, perioperative complications and donor sleep quality.Donors will be randomised into two groups: the intervention group will receive active pre-hydration consisting of three litres of intravenous Hartmann’s solution between midnight and 8 am before morning kidney donation, while the control group will not receive this. Both groups will receive unlimited oral fluids until midnight, as is routine. Plasma NGAL will be measured at pre-specified perioperative time points, intraoperative haemodynamic data will be collected using non-invasive cardiac output monitoring and clinical notes will be used to obtain demographic and clinical data. The researcher will be blinded to the donor fluid hydration status. Blinded statistical analysis will be performed on an intention-to-treat basis. A prospective power calculation estimates a required sample size of 86 patients.DiscussionThis study will provide important data, as there is currently little evidence about the use of donor preoperative fluids in laparoscopic nephrectomy. It is hoped that the results obtained will guide future clinical practice.Trial registrationThis study has been approved by the West of Scotland Research Ethics Committee 3 (reference no. 14/WS/1160, 27 January 2015) and is registered with the International Standard Randomised Controlled Trial Number Register (reference no. ISRCTN10199225, 20 April 2015).

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Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors

Cited by 4 publications

References 17 publications

Prospective assessment of urinary neutrophil gelatinase‐associated lipoprotein in living kidney donors: toward understanding differences between chronic kidney diseases of surgical and medical origin

Prospective assessment of urinary neutrophil gelatinase‐associated lipoprotein in living kidney donors: toward understanding differences between chronic kidney diseases of surgical and medical origin

Neutrophil Gelatinase-Associated Lipocalin, Fibroblast Growth Factor 23, and Soluble Klotho in Long-Term Kidney Donors

A comparison of the effects of oral vs. intravenous hydration on subclinical acute kidney injury in living kidney donors: a protocol of a randomised controlled trial

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