Plasma non-transferrin-bound iron uptake by the small intestine leads to intestinal injury and intestinal flora dysbiosis in an iron overload mouse model and Caco-2 cells

The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion

“…The quartet of layers collaboratively functions to preserve the operational steadiness of the intestinal barrier. Nonetheless, studies have discovered that disrupted intestinal morphology results in intestinal oxidative stress damage and ROS accumulation and induces apoptosis in intestinal epithelial cells [79]. Also, if the intestinal barrier integrity is compromised, it causes intestinal epithelial cells and localized chronic inflammation [80].…”

Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis

“…Studies have shown that elevated luminal iron levels are linked to a greater ability of healthy volunteers’ colon to produce free radicals [ 10 ]. Excessive intestinal iron in the gastrointestinal tract causes intestinal flora dysbiosis and intestinal injury, even increases the risk of colorectal cancer development [ 11 , 12 ]. Our previous studies also showed that iron overload caused intestinal inflammation, damaged villi morphology and reshaped the gut microbiota [ 13 , 14 ].…”

Trace elements in nutrition and health: a deep dive into essentiality and mechanism of their biological roles

“…These studies reveal that an administration of deferoxamine to porcine intestinal organoids resulted in non-significant difference in epithelial maturation markers (Yin et al, 2023), while in mouse intestinal organoids, ferric ammonium citrate (FAC) directly induced mucin expression and promoted goblet cell proliferation in both the ileum and colon (Liu et al, 2023). However, adding FAC to Caco-2 cells revealed that plasma Fe might lead to intestinal injury and dysbiosis of intestinal flora, potentially mediated by ZIP14 (Zhang et al, 2023). Thus, excessively low or high Fe levels can cause adverse impact on intestinal regeneration and barrier function.…”