Plasma noradrenaline and adrenaline levels in normal pregnancy and in pregnancy‐induced hypertension

Natrajan, P. G.; McGARRTGLE, H. H. G.; Lawrence, Daphne M.; Lachelin, Gillian C. L.

doi:10.1111/j.1471-0528.1982.tb04661.x

Cited by 57 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior studies on plasma catecholamines have been conflicting: observations have reported unchanged (24,39), increased (40), or decreased (22,23) catecholamine levels during pregnancy compared to nonpregnancy. We observed an increased plasma norepinephrine during the second trimester of pregnancy at baseline and during posture study, which was most pronounced during the third trimester.…”

Section: Discussionmentioning

confidence: 97%

The Renin-Aldosterone Response to Stimulation and Suppression During Normal Pregnancy

Bentley‐Lewis

Graves

Seely

2005

Hypertension in Pregnancy

View full text Add to dashboard Cite

Objective-During normal pregnancy, studies have shown increased activity of the reninangiotensin-aldosterone system (RAAS) and a dissociation of plasma renin activity (PRA) and aldosterone (Aldo) evidenced by a greater increase in Aldo relative to PRA. The aims of this study were to examine the RAAS response to stimulation by upright posture and suppression by saline infusion and to investigate the PRA-Aldo dissociation under these two conditions. Methods-We studied 24 healthy normotensive women (mean ± standard error of mean, ages 29 ± 1 yrs) in sodium (Na) balance in the second and third trimesters and postpartum. Subjects underwent a 24-hour urine collection which was analyzed for Na, norepinephrine (NE), epinephrine (Epi), and dopamine (DA); a posture study with analysis of blood pressure (BP), PRA, Aldo, NE, Epi, DA, and cortisol; and a 0.9% NaCl infusion study (500 mL/hr for 3 hrs) with analysis of BP, PRA, Aldo, cortisol, and digitalis-like factor (DLF). Analyses included paired t tests to compare posture and saline responses, repeated measures to compare across periods, and percent change to evaluate the PRA-Aldo dissociation.Results-During pregnancy, PRA, Aldo, BP, catecholamines, and cortisol levels were significantly greater in upright than left lateral decubitus (LLD) posture, and the percent change in Aldo was significantly greater than the percent change in PRA. During pregnancy in response to saline infusion, BP did not change; the PRA and Aldo significantly decreased; the percent change in Aldo was significantly greater than the percent change in PRA in the second trimester; and serum DLF and cortisol levels significantly decreased.Conclusions-In longitudinally studied normal pregnancy, PRA and Aldo levels were dissociated at baseline, with stimulation and, to a lesser degree, with suppression. Norepinephrine, adrenocorticotrophic hormone, and DLF may contribute to this dissociation, and clarification of these interactions may provide insight into the regulation of aldosterone during normal and hypertensive pregnancy.

show abstract

Section: Discussionmentioning

confidence: 97%

The Renin-Aldosterone Response to Stimulation and Suppression During Normal Pregnancy

Bentley‐Lewis

Graves

Seely

2005

Hypertension in Pregnancy

View full text Add to dashboard Cite

show abstract

“…In healthy pregnant women, plasma and urinary catecholamine levels are not or only slightly increased (12)(13)(14)(15)(16). Even in pre-eclampsia, plasma catecholamine levels are only slightly elevated.…”

Section: Introductionmentioning

confidence: 96%

ENDOCRINE DISORDERS IN PREGNANCY: Pheochromocytoma and pregnancy: a deceptive connection

Lenders¹

2012

European Journal of Endocrinology

135

139

View full text Add to dashboard Cite

A pheochromocytoma in a pregnant patient is one of the most threatening medical conditions for mother, fetus, and physician. Although extraordinarily rare with a frequency of 0.002% of all pregnancies, this tumor is notorious for its devastating consequences. As in non-pregnant patients, the signs and symptoms are quite variable but not specific, with hypertension being one of the most prominent signs. Confusion with the much more prevalent forms of pregnancy-related hypertension is the main cause of overlooking the diagnosis. If undiagnosed, maternal and fetal mortality is around 50%. Conversely, early detection and proper treatment during pregnancy decrease the maternal and fetal mortality to !5 and 15% respectively. For the biochemical diagnosis, plasma or urinary metanephrines are the tests of first choice since they have a nearly maximal negative predictive value. For reliable localization, only magnetic resonance imaging is suitable, with a sensitivity of more than 90%. When the tumor is diagnosed in the first 24 weeks of gestation, it should be removed by laparoscopic adrenalectomy after 10-14 days of medical preparation with the same drugs as in non-pregnant patients. If the tumor is diagnosed in the third trimester, the patient should be managed until the fetus is viable using the same drug regimen as for regular surgical preparation. Cesarean section with tumor removal in the same session or at a later stage is then preferred since vaginal delivery is possibly associated with higher mortality. Despite all technical diagnostic and therapeutic progress over the last decades, the key factor for further reduction of maternal and fetal mortality is early awareness and recognition of the potential presence of a pheochromocytoma in a pregnant patient with hypertension.

show abstract

“…The whole-day values of urinary NE excretion from the G1, working period, to the G4, non-working period, were consistently declined. The NE levels in serum or in urine during pregnancy are on controversy such as increased 33) , decreased 34) or not changed 29) . None of these reports, however, referred to the relationship between NE level and workload of pregnant shift workers.…”

Section: Nementioning

confidence: 99%

Effects of Night Work on Urinary Excretion Rates of 6-Sulfatoxymelatonin, Norepinephrine and Estriol in Pregnant Women.

Yamauchi

2004

INDUSTRIAL HEALTH

View full text Add to dashboard Cite

It has been suggested that shift work, night work in particular, affects worker's psychophysical health. However, the effects of night work on the health of pregnant women are not physiologically well elucidated. The effects of night work on the biological function of pregnant women were studied in the present study. Three pregnant and six non-pregnant nurses that engaged in fastrotating shift system cooperated for the study. The 24-h urine samples were collected in two time frames, daytime (07:00 to 23:00) and nighttime (23:00 to 07:00) on the day shift, the night shift and the days off. Urinary concentrations of 6-sulfatoxymelatonin and norepinephrine were measured by enzyme-linked immunosorbent assay and estriol by radioimmunoassay. The excretion profiles of urinary 6-sulfatoxymelatonin in the pregnant and the non-pregnant women were altered on the night shift, which might relate the derangement of circadian rhythm of melatonin secretion. The urinary norepinephrine level during the night work was considerably higher in the pregnant women, which indicated the presence of higher physical burden in them due to the night work. The urinary estriol level was not significantly affected by shift, day/night and individual factors, and the effect of night work on urinary estriol level of the pregnant women remained uncertain. The results of the present study suggested that the night work of the pregnant shift workers should be much more relieved.

show abstract

Plasma noradrenaline and adrenaline levels in normal pregnancy and in pregnancy‐induced hypertension

Cited by 57 publications

References 15 publications

The Renin-Aldosterone Response to Stimulation and Suppression During Normal Pregnancy

The Renin-Aldosterone Response to Stimulation and Suppression During Normal Pregnancy

ENDOCRINE DISORDERS IN PREGNANCY: Pheochromocytoma and pregnancy: a deceptive connection

Effects of Night Work on Urinary Excretion Rates of 6-Sulfatoxymelatonin, Norepinephrine and Estriol in Pregnant Women.

Contact Info

Product

Resources

About