Plasma Obestatin Concentrations Are Negatively Correlated with Body Mass Index, Insulin Resistance Index, and Plasma Leptin Concentrations in Obesity and Anorexia Nervosa

Nakahara, Toshihiro; Harada, Toshiro; Yasuhara, Daisuke; Shimada, N; Amitani, Haruka; Sakoguchi, Takeo; Kamiji, Mayra Mayumi; Asakawa, Akihiro; Inui, Akio

doi:10.1016/j.biopsych.2007.08.005

Cited by 107 publications

(74 citation statements)

References 21 publications

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“…In this study a significant negative correlation was noticed between obestatin and body mass index in patients underwent gastric sleeve which is agreed with a study of Nakahara T et al (28) Who detected that obestatin was negatively correlated wth body mass index (BMI) (r= -.74), glucose (r= -0.56), insulin (r= -0.55).…”

Section: IVsupporting

confidence: 92%

Impact Of Sustained Weight Loss Achieved Through Gastric Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects

Razak¹,

GhaniMBchB²,

Sami³

et al. 2014

IOSRJDMS

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Section: IVsupporting

confidence: 92%

Impact Of Sustained Weight Loss Achieved Through Gastric Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects

Razak¹,

GhaniMBchB²,

Sami³

et al. 2014

IOSRJDMS

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“…The authors suggested that the body composition may influence the balance of the ghrelin products and maybe this is the reason why there are different behavior regarding these hormones when comparing men and women. 27 Studies about obestatin in patients with CKD are scarce, but some studies have shown that obestatin levels are significantly increased in CKD patients. 28,29 A recent study published by our group observed that strength exercise for Table 2.…”

Section: Discussionmentioning

confidence: 99%

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

et al. 2015

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Chronic physical exercises may be beneficial to modulate appetite hormones as acyl-ghrelin (orexigenic) and obestatin (anorexigenic) in chronic kidney disease (CKD) patients; however, there are no data about the effects of acute exercises on these hormones. Thus, the aim of the present study was to assess the effect of acute resistance exercise on appetite hormones (acylghrelin and obestatin) of patients undergoing hemodialysis (HD). Twenty-five patients (44.7 ± 12.9 years, 68% women) on regular HD program were enrolled into two groups, 16 patients performed exercises and 9 patients comprised the control group. The patients performed the exercises in both lower limbs with ankle-cuffs and elastic bands, 30 min after the initiation of hemodialysis session. Blood samples of both the groups were drawn in the morning before and after 30 min with exercise session (exercise group) and, before and after the same time without exercise (control group). Acyl-ghrelin and obestatin plasma levels were measured using an enzyme immunometric assay. Acyl-ghrelin plasma levels did not change in both the groups. However, when stratified by gender the acyl-ghrelin increased significantly right after exercise in men [32.1 pg/mL (25.6-41.2) to 46.0 pg/mL (39.0-59.5)] (p ¼ 0.04). Obestatin plasma levels reduced after a single bout of exercise and changes remained significantly when the sample was stratified by gender. There was no change in obestatin plasma levels in control group. A single bout of resistance exercise seems to modulate the levels of appetite hormones in HD patients.

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“…Circulating obestatin concentrations have been reported to be either reduced (Anderwald-Stadler et al 2007;Nakahara et al 2008) or, more frequently, increased (Guo et al 2007;Prodam et al 2011;Reinehr et al 2008;Vicennati et al 2007) in obesity. Based on available data, it is difficult to explain these contrasting findings that seem to depend mainly on sample size, age, and ethnicities.…”

Section: Introductionmentioning

confidence: 99%

Ghrelin Gene Products in Acute and Chronic Inflammation

Prodam,

Filigheddu

2014

Arch. Immunol. Ther. Exp.

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Ghrelin gene products-the peptides ghrelin, unacylated ghrelin, and obestatin-have several actions on the immune system, opening new perspectives within neuroendocrinology, metabolism and inflammation. The aim of this review is to summarize the available evidence regarding the less known role of these peptides in the machinery of inflammation and autoimmunity, outlining some of their most promising therapeutic applications.

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Plasma Obestatin Concentrations Are Negatively Correlated with Body Mass Index, Insulin Resistance Index, and Plasma Leptin Concentrations in Obesity and Anorexia Nervosa

Cited by 107 publications

References 21 publications

Impact Of Sustained Weight Loss Achieved Through Gastric Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects

Impact Of Sustained Weight Loss Achieved Through Gastric Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

Ghrelin Gene Products in Acute and Chronic Inflammation

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