Plasma omega-3 polyunsaturated fatty acids and recurrence of endometrial cancer

Abstract

Background: Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. Method: Women diagnosed with endometrial cancer (EC) between 2008 and 2013 and underwent surgery at Fudan University Shanghai Cancer Center of China were recruited. Survival status was followed up through September 2017. EC recurrence and total cause deaths were identified through medical record and telephone interview. In total, 202 patients with enough plasma samples at time of surgery were included. There were 195 patients who provided baseline plasma and survival information included in the current study. Plasma omega-3 PUFAs were measured by GC-FID. Cox Proportional Hazard model adjusted for potential cofounders was used to estimate HRs and 95% CIs. Results: Median follow-up time for patients was 58 months after surgery. A total of 13 recurrences and 11 all-cause deaths, of which, 2 deaths from EC, were identified. Level of plasma EPA was higher in recurrent patients than total patients (0.78% vs 0.51%, P = 0.015). Higher plasma eicosapentaenoic acid (EPA) level trended to have positive association with EC recurrence (P-trend = 0.04), although comparing to the lowest tertile, the highest tertile of EPA level was not significantly associated with increased risk of EC recurrence (HR T3vsT1 = 6.02; 95%CI = 0.7-52.06). The association between total omega-3 PUFA and EC recurrence tended to be stronger among patients with deeper myometrial invasion (OR = 3.41; 95%CI = 1.06-10.95; P-interaction = 0.04). Conclusions: Higher plasma EPA level was significantly associated with EC recurrence. Further studies are warranted to confirm these findings.

GGTLC1 knockdown inhibits the progression of endometrial cancer by regulating the TGF-β/Smad signaling pathway

“…Furthermore, enrichment analyses were conducted to explore the gene functions and pathways associated with GGTLC1. Notably, our findings indicated significant enrichment in GO categories such as fatty acid derivative metabolic processes and glucuronate metabolic processes, both of which have previously been linked to EC pathophysiology [ 24 ]. KEGG pathway analysis highlighted the critical roles of steroid hormone biosynthesis and cytochrome P450 metabolism.…”

Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients

“…Furthermore, the positive correlation of 3-hydroxybutyrate with PUFA was higher than with other lipid metabolite species, implicating PUFA-mediated inhibition of T cell immune response by modified lipid rafts [ 69 ]. PUFA-mediated tumor progression is also observed in colorectal cancer and only endometrial cancer with reoccurrence [ 70 , 71 ]. Such findings explain why ketone bodies were negatively correlated with MCP-1 and IL-18 and positively correlated with IL-10.…”

Fish consumption and risk of prostate cancer or its mortality: an updated systematic review and dose–response meta-analysis of prospective cohort studies

“…Inflammation is a potential risk factor for some cancers (34)(35)(36). In contrast, some reports are available on the increased risk of certain cancers after intake of omega-3 fatty acids and their dietary sources (37,38). In addition to this inconsistency, findings from observational studies on the relationship between fish consumption and prostate cancer risk are conflicting.…”