Plasma osteoprotegerin levels are inversely associated with nonalcoholic fatty liver disease in patients with type 2 diabetes: A case–control study in China

Niu, Yixin; Zhang, Weiwei; Yang, Zhen; Li, Xiaoyong; Fang, Wenjun; Zhang, Hongmei; Wang, Suijun; Zhou, Houguang; Fan, Jian‐Gao; Qin, Li; Su, Qing

doi:10.1016/j.metabol.2015.12.005

Cited by 22 publications

(18 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 64 , 88 Similar results were also found in patients with type 2 diabetes, where Niu et al have shown that plasma OPG levels are negatively associated with NAFLD. 65 …”

Section: What Are the Links Between Nafld And Decreased Bone Mass?mentioning

confidence: 99%

Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

Filip¹,

Radzki

Bieńko

2018

CIA

View full text Add to dashboard Cite

Excess fat deposition and insulin resistance are considered the main risk factors for nonalcoholic fatty liver disease (NAFLD), and therefore, not surprisingly, the global prevalence of NAFLD increases in parallel with both obesity and type 2 diabetes. Although deterioration of bone homeostasis in patients with NAFLD is commonly observed, its etiology has not been fully elucidated yet. It was shown in several studies that bone tissue seems to be independently associated with NAFLD. A mechanistic perspective puts the liver at the center of mutual interdependencies obviously involving adipose tissue and muscles and also the bone matrix and bone cells, which are relatively novel. In this review, various pathophysiological mechanisms and possible mediating molecules that may interplay between NAFLD and bone tissue are described. Chronic inflammation, vitamin D3, growth hormone, insulin-like growth factor 1, osteopontin, fetuin-A, irisin, osteocalcin, and osteoprotegerin from osteoblasts have been proposed as mediators of mutual interactions among the skeleton, fatty tissue, and liver. Although to date there are still many issues that have not been elucidated, growing evidence suggests that screening and surveillance of bone mineral density in patients with NAFLD should be considered in future strategies and guidelines for NAFLD management.

show abstract

“… 64 , 88 Similar results were also found in patients with type 2 diabetes, where Niu et al have shown that plasma OPG levels are negatively associated with NAFLD. 65 …”

Section: What Are the Links Between Nafld And Decreased Bone Mass?mentioning

confidence: 99%

Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

Filip¹,

Radzki

Bieńko

2018

CIA

View full text Add to dashboard Cite

show abstract

“…Studies evaluating adult populations have indicated a potential relationship between insulin resistance, metabolic syndrome, NAFLD, and concentrations of OPG ( 10 , 13 - 16 ). These studies reported that serum OPG level could be used as a non-invasive marker of liver damage in NAFLD ( 13 , 16 ). However, studies concerning OPG level and its relationship with insulin resistance in children are limited ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Osteoprotegerin with Obesity, Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Children

Erol¹,

Gayret²,

Nacaroğlu³

et al. 2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

BackgroundOsteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily. Reduced OPG levels are related to obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD).ObjectivesThe aim of this study was to evaluate the relationship between OPG levels, obesity, insulin resistance, and NAFLD in pediatric patients.MethodsThis was a prospective, cross-sectional, controlled study that was conducted in the department of pediatrics at Bagcilar training and research hospital in Istanbul, Turkey, between April and August 2015. The study was performed on 107 children with obesity and 37 controls aged 5 - 17 years. In the obese subset, 62 patients had NAFLD. Homeostatic model assessment-insulin resistance (HOMA-IR) was used to calculate insulin resistance. Insulin resistance was defined as a HOMA-IR value greater than 2.5. Plasma OPG levels were measured using enzyme-linked immunosorbent assays. NAFLD was diagnosed by hepatic ultrasound.ResultsThe mean age was 11.25 ± 3.38 years in the patient group and 10.41 ± 3.15 years in the control group. The OPG level in the obese group with the mean of 55.20 ± 24.55 pg/mL (median = 48.81 pg/mL) was significantly lower than that in the control group with the mean of 70.78 ± 33.41 pg/mL (median = 64.57 pg/mL) (P = 0.0001). The optimal cut-off point (sensitivity, specificity) of the OPG level for the diagnosis of obesity was ≤ 46, 19 pg/mL. According to logistic regression analysis, fasting insulin (P = 0.036) and OPG (P = 0.01) levels were most affected by obesity. In the obese patients, who had HOMA-IR < 2.5, the mean level of OPG was 58.91 ± 6.88729 pg/mL (median = 49.55). In the obese patients, who had HOMA-IR ≥ 2.5, the mean level of OPG was 54.19 ± 22.21 pg/mL (median = 48.47). No significant correlations were found between OPG and HOMA-IR (P = 0.791). No statistically significant difference was observed in the mean OPG between patients with hepatosteatosis (mean = 54.55 ± 25.01 pg/mL) (median = 49.46) and those without the disease (56.30 ± 24.02 pg/mL) (mean = 48.34) (P = 0.089).ConclusionsWe confirmed that serum OPG concentrations reduce in obese children. However, no correlation was identified between OPG and insulin resistance. OPG levels are not meaningful in the diagnosis of NAFLD in children with obesity.

show abstract

“…Osteoprotegerin is a soluble receptor in the tumor necrosis factor family which seems to be related to glucose control. To investigate if osteoprotegerin may be related to NAFLD in T2DM, Niu et al [84] examined 367 patients with ultrasound-diagnosed NAFLD and 379 controls with T2DM but without NAFLD for this case-control study in China. Osteoprotegerin was approximately 18% lower in patients with NAFLD versus diabetic controls and were correlated with age and systolic blood pressure.…”

Section: Plasma Osteoprotegerin Levels Are Inversely Associated With mentioning

confidence: 99%

Research advances in metabolism 2017

et al. 2018

View full text Add to dashboard Cite

Plasma osteoprotegerin levels are inversely associated with nonalcoholic fatty liver disease in patients with type 2 diabetes: A case–control study in China

Cited by 22 publications

References 41 publications

Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

Association of Osteoprotegerin with Obesity, Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Children

Research advances in metabolism 2017

Contact Info

Product

Resources

About