Plasma Oxytocin and Vasopressin do not Predict Neuropeptide Concentrations in Human Cerebrospinal Fluid

Kagerbauer, Simone Maria; Martin, Jan; Schuster, Tibor; Blobner, Manfred; Kochs, Eberhard; Landgraf, Rainer

doi:10.1111/jne.12038

Cited by 192 publications

(151 citation statements)

References 54 publications

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“…It remains unclear whether peripheral OXT or AVP levels represent the central neuropeptide levels and activities. Some studies in pregnant women [51], adult suicide attempters [52], and adult patients undergoing surgical procedures [53] have indicated a lack of correlation between OXT concentrations in plasma and cerebrospinal fluid (CSF). However, a recent study on children and adult patients have reported a positive correlation of OXT levels between the two compartments and this relationship is stronger when only children are included in the analysis [54].…”

Section: Discussionmentioning

confidence: 99%

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Zhang

Dai

et al. 2016

Neurosci. Bull.

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Autism spectrum disorder (ASD) is defined by impairments of social interaction and the presence of obsessive behaviors. The ''twin'' nonapeptides oxytocin (OXT) and arginine-vasopressin (AVP) are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of children. As expected, children with ASD had lower plasma OXT levels than gender-matched controls (P = 0.028). No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication (Rho = -0.22, P = 0.076), while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects (Rho = -0.231, P = 0.079). Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children (P = 0.072). In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

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Section: Discussionmentioning

confidence: 99%

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Zhang

Dai

et al. 2016

Neurosci. Bull.

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“…Accordingly some studies have shown differential central and peripheral release of the peptides under certain conditions, in humans (Kagerbauer et al, 2013) and in rodents (Wotjak et al, 1998). On the other hand, several studies have shown a relation between peripheral concentration levels and behaviors controlled centrally (Fries et al, 2005;Strathearn et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Long-term programming of enhanced aggression by peripuberty stress in female rats

Cordero

Ansermet

Sandi

2013

Psychoneuroendocrinology

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Summary Human literature has linked adverse early life experiences with an increased risk to develop violent behaviors in both boys and girls. We have previously shown that male rats submitted to stress during the peripuberty period display as adults abnormal aggressive behavior against both male intruders and female partners. In the present study, we examined whether the same stress protocol would affect the development of aggressive behaviors in female rats. We evaluated the behavior of these peripuberty stressed female rats when confronted, at adulthood, with either female or male intruders, and during their cohabitation with male partners. Given that estrus cycle influences mood and aggressive behaviors, female aggressive behavior was assessed at different estrus cycle phases: estrus and diestrus, and during pregnancy and lactancy. Additionally, we evaluated postpartum plasma levels of vasopressin, oxytocin and corticosterone, hormones associated with aggression and the regulation of social behavior. Compared to control females, females submitted to stressful events during puberty exhibited higher and more sustained rates of aggression during adulthood independently on the estrus cycle or the sex of the intruder, and they had higher levels of plasma vasopressin. Significant correlations between plasma levels of vasopressin and corticosterone and aggressive behavior were also found. Strikingly, our results showed opposite intragroup correlations suggesting a different role of these hormones on aggression depending on life experiences. We provide here an animal model, devoid of cultural influences strongly supporting a role for biological factors in the development of aggressive behaviors following exposure to stressful events at puberty in females. #

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“…Moreover, most human studies rely on plasma OT concentrations for the prediction of behavioral phenotypes, assuming that these peripherally derived measures reflect central OT concentrations. This basic premise has been challenged by studies showing that there is no correlation between plasma and CSF OT concentrations (Altemus et al, 2004; Kagerbauer et al, 2013), but confirmed by others, which found significant between-compartment correlations (Carson et al, 2015). Divergent findings like these, whose clarification is pivotal for advancement of behavioral and psychiatric neuroendocrinology, may partly result from methodological heterogeneity, which leads to an issue of particular concern.…”

Section: Methodological Challenges Future Directions and Translatmentioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

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Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

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Plasma Oxytocin and Vasopressin do not Predict Neuropeptide Concentrations in Human Cerebrospinal Fluid

Cited by 192 publications

References 54 publications

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Long-term programming of enhanced aggression by peripuberty stress in female rats

Oxytocin pathways in the intergenerational transmission of maternal early life stress

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