Plasma oxytocin in human pregnancy and parturition

Geest, Koen De; Thiéry, Michel; Piron-Possuyt, G.; Driessche, R. Vanden

doi:10.1515/jpme.1985.13.1.3

Cited by 78 publications

(68 citation statements)

References 37 publications

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“…In both groups, some of the women demonstrated recurrent rapid peaks in their plasma oxy tocin. A similar pattern in oxytocin levels in pregnant and nonpregnant women has previously been reported by us and others [15,16,27], Thus, although there were clear-cut metabolic differ ences between the normal pregnant and GDM women, no corresponding difference in oxytocin levels was found. The lack of a difference in fasting levels of oxytocin is in accordance with a previous study where patients with type 1 diabetes were compared with nondiabetic controls [8], The diabetic patients were found to respond with sig nificantly higher oxytocin levels following insulin-in duced hypoglycemia than the control group did.…”

supporting

confidence: 88%

“…When the regulation of the blood glucose level is insufficient, gestational diabetes mellitus (GDM) develops. GDM has been defined as a carbohydrate intolerance of variable severity, with onset or first recognition during the present pregnancy [ 13], During pregnancy, a gradual elevation in oxytocin lev els towards term is found in women and in ewes [14][15][16], Since GDM normally represents a mild form of diabetes and is detected very early during follow-ups of maternal health, it was considered of interest to compare the levels of oxytocin and some metabolic parameters between this group of patients and normal healthy pregnant controls. For this purpose, plasma levels of oxytocin were recorded in connection with a standardized breakfast and related to the levels of insulin, glucagon and glucose.…”

Section: Introductionmentioning

confidence: 99%

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Is Oxytocin Involved in the Deterioration of Glucose Tolerance in Gestational Diabetes?

Stock

Bremme²,

Uvnäs‐Moberg³

1993

Gynecol Obstet Invest

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The present study assessed the possible role of oxytocin in the deterioration of glucose tolerance in gestational diabetes. Plasma levels of oxytocin, insulin, glucagon and glucose were measured at the time of a 400-kcal breakfast meal tolerance test in 12 women with gestational diabetes and 12 normal pregnant women in the third trimester. The gestational diabetic women had higher basal levels of insulin and an enhanced, delayed and prolonged insulin response to the breakfast. The same differences occurred in the glucose levels. There was no significant difference in the glucagon levels between the two groups. In the normal pregnant women, a significant (p < 0.05) though small rise in glucagon levels occurred 30 min after the ingestion of the breakfast. Oxytocin levels were not affected by the breakfast, and there was no clear difference between the two groups. The metabolic differences between the normal pregnant and gestational diabetic women were not related to any differences in oxytocin levels. In conclusion, we found no evidence of a role of oxytocin in the alteration of glucose metabolism in women with gestational diabetes. However, since alterations in oxytocin levels of possible significance for an impaired glucose tolerance are found in type 1 diabetic and extremely obese patients, further studies are needed in women with gestational or manifest diabetes.

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supporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Is Oxytocin Involved in the Deterioration of Glucose Tolerance in Gestational Diabetes?

Stock

Bremme²,

Uvnäs‐Moberg³

1993

Gynecol Obstet Invest

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“…However, it is not clear whether provision of analgesia influences plasma concentrations of oxytocin. While Goodfellow et al ~~ reported a decrease in plasma concentration of oxytocin with epidural analgesia, this was not confirmed by Behrens et al H and de Geest et al 12 Unfortunately these investigators did not standardize the medications used to initiate epidural analgesia, the sensory distribution of analgesia, the stage of labour or the use of exogenous oxytocics. In addition, the use of intravenous fluid bolus before the epidural block was not documented.…”

mentioning

confidence: 94%

Epidural analgesia in early labour blocks the stress response but uterine contractions remain unchanged

Scull¹,

Hemmings

Carli³

et al. 1998

Can J Anaesth

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Purpose: To determine the effect of epidural analgesia on biochemical markers of stress, plasma oxytocin concentrations and frequency of uterine contractions during the first stage of labour. Methods: Nine nulliparous women, in spontaneous labour, with a singleton fetus and cervical dilatation < 5 cm were enrolled. Epidural bupivacaine 0.25% (range I 0 -14 ml) was administered and bilateral sensory blockade to ice 0-8 -L4) achieved. Blood samples were collected before the epidermal block and every I0 min for one hour after the block was achieved for the measurement of plasma beta-endorphin, cortical, glucose, lactate and oxytocin concentrations. No exogenous oxytocin was given. Intensity of pain was assessed at the time of the blood sampling using a I0 cm visual analogue scale (VAS). The frequency of uterine contractions was recorded for 60 rain before and after the epidural block.Results: There was a decrease in plasma beta-endorphin and cortisol concentrations after epidural block (P < 0.01).There were no changes in plasma glucose and lactate concentrations. The mean VAS for pain decreased I0 rain after epidural block was achieved and remained < 2 throughout the study period (P < 0.001 ). Mean plasma oxytocin concentrations did not change. The frequency of uterine contractions before and after the epidural block was similar. Condusions: The metabolic stress response to the pain of labour was attenuated by epidural analgesia. In contrast, plasma oxytocin concentration and frequency of uterine contractions were unaffected by the attenuation of metabolic stress response.Object~ : D&erminer reffet de l'analg&ie p&idurale sur les marqueurs biochimiques de stress, les concentrations plasmatiques d'oxytocine et la frdquence des contractions ut&ines pendant le premier stade du travail. M&hode : Neuf femmes nullipares, en travail spontan6, porteuse d'un seul foetus et pr&entant une dilatation du col de l'ut&us < 5 cm, ont dtd recrut&s. On a administrd de la bupivaca'ine p&idurale ~ 0,25 % (de I0 ~ 14 ml) et on a procddd ~ un blocage sensoriel bilat&al ~ la glace (-I-8 -I_4). On a prdlevd des &hantillons de sang avant le point dermique et ~ toutes les I0 minutes pendant une heure apt& le bloc afin de mesurer les concentrations plasmatiques de 13-endorphine, de cortisol, de glucose, de lactate et d'oxytocine. On n'a pas administrd d'oxytocine exog~ne. l'intensitd de la douleur a 6td dvalu6e au moment des prdl~vements sanguins en utilisant une &helle visuelle analogique (EVA) de 10 cm. La frdquence des contractions ut&ines a &d enregistr6e pendant 60 minutes avant et apr& I'analg6sie p&idurale. R&ultats : On a observd une baisse de la 13-endorphine plasmatique et des concentrations de cortisol apr& ranalg&ie p&idurale (P < 0,01). II n'y a pas eu de changements dans les concentrations de glucose et de lactate. La moyenne de rEVA pour la dou~eur a diminu~, I0 minutes apr~s le bloc p6ridural et est demeur& < 2 pendant toute la dur& de l'&ude (m < 0,00 I). Les concentrations moyennes d'oxytocine front pas changd. La frdquence...

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“…Some studies found that women who received EDA had lower circulating OT levels during labor (Goodfellow et al, 1983;Rahm et al, 2002;Stocche et al, 2001), whereas others did not (de Geest et al, 1985;Scull et al, 1998). It appears that the closer to EDA administration blood samples are obtained, the less pronounced the effect of EDA on OT levels.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young

Jonas

Woodside

2016

Hormones and Behavior

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Plasma oxytocin in human pregnancy and parturition

Cited by 78 publications

References 37 publications

Is Oxytocin Involved in the Deterioration of Glucose Tolerance in Gestational Diabetes?

Is Oxytocin Involved in the Deterioration of Glucose Tolerance in Gestational Diabetes?

Epidural analgesia in early labour blocks the stress response but uterine contractions remain unchanged

Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young

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