Plasma parathyroid hormone-related peptide and bone metabolism in periparturient dairy cows

Filipović, Natalija; Stojević, Zvonko; Zdelar-Tuk, Maja; Kušec, Vesna

doi:10.1556/avet.56.2008.2.11

Cited by 14 publications

(11 citation statements)

References 21 publications

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“…e present investigations found that the bone formation biomarkers (OC and b-ALP) did not change significantly during the periparturient period of the goats. is is in agreement with data in dairy cows, where significant changes in the activity of b-ALP in the blood serum were not established during late pregnancy and early lactation [24]. On the other hand, the activity of bone formation b-ALP in the serum of mares was lower in late pregnancy than in early lactation [12].…”

Section: Resultssupporting

confidence: 92%

“…Veterinary Medicine International estradiol were reported to influence the rate of bone turnover [12,22,24]. Filipovic et al [12] suggested that high concentrations of estradiol in the blood during late pregnancy could cause a decrease in the number of osteoblasts because estrogens suppress the self-renewal of osteoblast progenitors, while their antiosteoclastogenic effects are thought to be secondary to impaired osteoblast formation [25].…”

Section: Resultsmentioning

confidence: 99%

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Serum Concentration of Bone Metabolism Biomarkers in Goats during the Transition Period

Tadjine

2020

Veterinary Medicine International

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Objective. During the transition period, the animal experiences a series of nutritional, physiological, and social changes. e objective of the present study was to evaluate the influence of the periparturient period in goats on the serum concentrations of the bone biomarkers osteocalcin (OC), bone-specific alkaline phosphatase (b-ALP), and pyridinoline cross-links (PYD). Method. Blood samples were collected from fifteen female goats during the periparturient period 3 wk before expected parturition (T − 3), within 12 h of parturition (T 0), and 3 wk after parturition (T +3). Results. Compared to a value of 77.67 ± 47.6 ng/mL at T − 3, the serum concentrations of OC measured 51.91 ± 22.09 ng/mL at T 0 and 72.61 ± 35.21 ng/mL at T +3. A comparison of OC values at T − 3, T 0, and T +3 did not reveal any significant difference (P > 0.05). Compared to a value of 42.00 ± 19.50 U/L at T − 3, the serum concentration of b-ALP measured 32.49 ± 15.41 U/L at T 0 and 34.31 ± 18.89 U/L at T +3. A comparison of b-ALP values at T − 3, T 0, and T +3 did not reveal any significant difference (P > 0.05). Compared to a value of 17.86 ± 9.15 nmol/L at T − 3, the serum concentration of PYD decreased significantly at T 0 to a value of 7.48 ± 4.50 nmol/L (P < 0.0001). At T +3, the PYD serum concentration measured 7.72 ± 2.91 nmol/L, which differed significantly from T − 3 values (P < 0.05). Conclusion. e results of this study showed that the bone formation biomarkers (OC and b-ALP) did not change significantly during the periparturient period, while the bone resorption biomarker decreased significantly at parturition compared to 3 wk before and 3 wk after parturition. e significantly increased serum estrogen around parturition may have had a role in the increased bone resorption at this time.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Serum Concentration of Bone Metabolism Biomarkers in Goats during the Transition Period

Tadjine

2020

Veterinary Medicine International

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“…It looks like bone anabolic activity was at the same rate in both groups of cows. Interestingly, we measured much higher values of bALP in our cows than Filipovi} et al (2008) 14 days before calving and 10 days after calving. Our opinion is that the anabolic effect in our study is due to very high estrogen levels in cows just before calving and estrogen is known to be a osteoprotective anabolic hormone (Riggs et al, 2002).…”

Section: Resultsmentioning

confidence: 47%

“…Some reports of their use in different animal species are published in scientific and professional literature (Allen, 2003). They are already implemented in diagnostic procedures also in dairy cattle (Liesegang et al, 1998;Iwama et al, 2004;Holtenius and Ekelund, 2005;Filipovi} et al 2008;Stari~et al, 2008a,b).…”

Section: Introductionmentioning

confidence: 99%

Biochemical markers of bone metabolism in dairy cows with milk fever

Starič¹,

Zadnik²

2010

Acta vet. (Beogr.)

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Bone metabolism was investigated in 8 healthy and 12 dairy cows suffering from milk fever (MF) in intensive dairy production. Blood samples were taken within 48 hours after calving in healthy cows and before treatment in cows with MF. Bone and mineral metabolism were evaluated by measuring blood serum bone resorption biomarker Cterminal telopeptide of type I collagen (CTx) and bone formation biomarker bone-specific alkaline phosphatase (bALP) beside the classical panel: total calcium (Ca), inorganic phosphate (iP), magnesium (Mg) and alkaline phosphatase (ALP). The results were statistically analyzed and compared between the two groups. Mean Ca value in cows with milk fever was 1.01±0.29 mmol/L and in healthy cows it was significantly (p<0.05) higher (1.94± 0.04 mmol/L). All the cows were also hypophosphatemic with lower phosphorus values (p<0.05) in MF cows. Some cows with MF were also hypermagnesemic, but the difference in Mg concentrations between the two groups was not significant. Mean total ALP and bALP activity were higher in cows with MF (65±17.7 U/L and 21.3±8.5 U/L, respectively) than in healthy cows (55.9±7.0 U/L and 20.5±8.9 U/L, respectively). The mean concentration of blood serum CTx was lower in cows with MF (0.212±0.091 ng/L) than in healthy cows (0.417± 0.252 ng/L), but as for bALP not significantly

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“…It is very likely that PTHrP expressed by mammary cells exerts a key function in the homeostatic adaptation to lactation in cows. In fact, plasma PTHrP has been shown to increase after parturition in cows (Filipović et al, 2008). Peripheral serotonin has recently been shown to regulate PTHrP gene expression (Hernandez et al, 2012) and, therefore, is involved (through PTHrP) in mammary epithelial cell Ca transport (Laporta et al, 2014).…”

mentioning

confidence: 99%

Epidemiology of subclinical hypocalcemia in early-lactation Holstein dairy cows: The temporal associations of plasma calcium concentration in the first 4 days in milk with disease and milk production

Neves

Leno

Bach

et al. 2018

Journal of Dairy Science

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The objectives of this study were to characterize the epidemiology of subclinical hypocalcemia (SCH) in Holstein dairy cows by assessing the temporal associations of plasma Ca concentrations in the first 4 d in milk (DIM) with the risk of cows being diagnosed with metritis or displaced abomasum (or both), and milk production across the first 15 wk of lactation. A prospective cohort study was conducted in 2 dairy herds in New York State, in which cows had a blood sample collected daily for the first 4 DIM. A total of 396 Holstein cows (137 primiparous and 259 multiparous) were enrolled. Multivariable Poisson regression models were built to evaluate the associations of plasma Ca concentration at each of the 4 d following parturition with the risk of primiparous cows being diagnosed with metritis and multiparous cows being diagnosed with metritis, displaced abomasum, or both. Similarly, generalized linear mixed models were built to evaluate the associations of plasma Ca concentration with milk production across the first 15 wk of lactation. Plasma Ca concentration was assessed on a continuous scale in all models; dichotomization and SCH classification only occurred in the final models if the Ca concentration variable was meaningful by creating an optimized threshold based on receiver operating characteristic curve analysis. Plasma Ca concentration assessed at 1 DIM was not associated with the risk of metritis in primiparous cows, but an association was observed at 2, 3, and 4 DIM (critical thresholds were plasma Ca concentration ≤2.15, 2.10, and 2.15 mmol/L, respectively). Plasma Ca concentration was associated with the risk of metritis or displaced abomasum diagnosis (or both) for 2nd parity animals at 2 DIM (threshold ≤1.97 mmol/L), and at 4 DIM for 3rd and greater lactations (threshold ≤2.20 mmol/L). Reduced plasma Ca concentration was associated with higher milk production when assessed at 1 DIM in primiparous and multiparous cows, and lower milk production when assessed at 4 DIM in multiparous cows only. For primiparous cows, plasma Ca concentration was not associated with lower milk production at any of the DIM assessed. In conclusion, assessments of SCH at the individual cow level must take into account the DIM of Ca concentration measurement and parity of the cow, as the epidemiology of the disorder was demonstrated to be highly dependent on these variables. This study advances the knowledge of the epidemiology of SCH and better establishes thresholds for optimizing SCH diagnosis.

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Plasma parathyroid hormone-related peptide and bone metabolism in periparturient dairy cows

Cited by 14 publications

References 21 publications

Serum Concentration of Bone Metabolism Biomarkers in Goats during the Transition Period

Serum Concentration of Bone Metabolism Biomarkers in Goats during the Transition Period

Biochemical markers of bone metabolism in dairy cows with milk fever

Epidemiology of subclinical hypocalcemia in early-lactation Holstein dairy cows: The temporal associations of plasma calcium concentration in the first 4 days in milk with disease and milk production

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