Abstract:Background: The aim of this study is to investigate the value of plasma PTX3 level for assessing peripheral artery disease (PAD) and clinical outcome in hemodialysis (HD) patients. Methods: The ankle-brachial index (ABI) was measured in HD patients. PTX3 levels in 116 HD patients were measured by ELISA. Results: Overall, 116 HD patients were enrolled; 21 (18%) patients had PAD. Using the ROC curve analysis for PAD, PTX3 (cut-off value 4.06 ng/ml, AUC 0.901, p < 0.0001) showed a significantly better positive pr… Show more
“…And 1 additional study was retrieved using hand searching the reference lists of included studies. Therefore, 10 cohort studies were included in this meta-analysis [8–17], of which 10 studies were included for meta-analysis of all-cause mortality [8–17], and 6 were included for CV mortality [8–10, 12, 15, 16]. Figure 1 showed the summary of study identification process.Fig.…”
Section: Resultsmentioning
confidence: 99%
“…They were published from 1996 to 2015. 5 articles were from Asia [9, 13–16], 2 from the United States [8, 11], 2 from Europe [12, 17], and 1 multinational study from Asia, USA and Europe [10]. An ABI value < 0.9 was the single diagnostic criteria of PAD in 4 studies [8, 9, 13, 15].…”
Section: Resultsmentioning
confidence: 99%
“…Of the 10 articles included, 8 reported the means duration of dialysis (min: 5.8 years; max: 19.8 years) [9, 11–13, 15–17]. For the 6 studies (2 were retrospective, and 4 were prospective, n = 31,794) included to analyze CVD mortality [8–10, 12, 15, 16], only 1 study did not use ABI < 0.9 to diagnose PAD [10]. …”
Section: Resultsmentioning
confidence: 99%
“…For the 6 studies (2 were retrospective, and 4 were prospective, n = 31,794) included to analyze CVD mortality [8–10, 12, 15, 16], only 1 study did not use ABI < 0.9 to diagnose PAD [10]. …”
BackgroundRecent studies have shown an association between peripheral arterial disease (PAD) and increased risk of mortality in hemodialysis (HD) patients; however, the estimates vary widely and are inconsistent. It is necessary to elucidate the degree of mortality risk for PAD patients in HD population.MethodsPubMed, EMBASE, Web of Science and Cochrane Library (from inception to September 4th, 2016) were systematically searched for cohort studies assessing the association between PAD and mortality in HD patients. We calculated the pooled risk ratios (RRs) with 95% confidence intervals (CI) of all-cause and cardiovascular (CV) mortality using random effects models. Subgroup analyses were conducted to explore the source of heterogeneity.ResultsThe search identified 2,973 potentially eligible records and 10 studies (n = 32,864) were included. Our meta-analysis revealed that PAD significantly increased the risk of all-cause mortality (RR 2.15, 95 % CI 1.67–2.77, n = 32,864) and CV mortality (RR 2.99, 95 % CI 1.66-5.38, n = 31,794) in HD patients after multivariate adjustment. Subgroup analyses showed the study design and follow-up time might be two sources of heterogeneity.ConclusionPAD may be a prognostic marker of all-cause and CV mortality in HD patients. More attention should be paid to diagnosis and management of PAD in HD patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-016-0397-1) contains supplementary material, which is available to authorized users.
“…And 1 additional study was retrieved using hand searching the reference lists of included studies. Therefore, 10 cohort studies were included in this meta-analysis [8–17], of which 10 studies were included for meta-analysis of all-cause mortality [8–17], and 6 were included for CV mortality [8–10, 12, 15, 16]. Figure 1 showed the summary of study identification process.Fig.…”
Section: Resultsmentioning
confidence: 99%
“…They were published from 1996 to 2015. 5 articles were from Asia [9, 13–16], 2 from the United States [8, 11], 2 from Europe [12, 17], and 1 multinational study from Asia, USA and Europe [10]. An ABI value < 0.9 was the single diagnostic criteria of PAD in 4 studies [8, 9, 13, 15].…”
Section: Resultsmentioning
confidence: 99%
“…Of the 10 articles included, 8 reported the means duration of dialysis (min: 5.8 years; max: 19.8 years) [9, 11–13, 15–17]. For the 6 studies (2 were retrospective, and 4 were prospective, n = 31,794) included to analyze CVD mortality [8–10, 12, 15, 16], only 1 study did not use ABI < 0.9 to diagnose PAD [10]. …”
Section: Resultsmentioning
confidence: 99%
“…For the 6 studies (2 were retrospective, and 4 were prospective, n = 31,794) included to analyze CVD mortality [8–10, 12, 15, 16], only 1 study did not use ABI < 0.9 to diagnose PAD [10]. …”
BackgroundRecent studies have shown an association between peripheral arterial disease (PAD) and increased risk of mortality in hemodialysis (HD) patients; however, the estimates vary widely and are inconsistent. It is necessary to elucidate the degree of mortality risk for PAD patients in HD population.MethodsPubMed, EMBASE, Web of Science and Cochrane Library (from inception to September 4th, 2016) were systematically searched for cohort studies assessing the association between PAD and mortality in HD patients. We calculated the pooled risk ratios (RRs) with 95% confidence intervals (CI) of all-cause and cardiovascular (CV) mortality using random effects models. Subgroup analyses were conducted to explore the source of heterogeneity.ResultsThe search identified 2,973 potentially eligible records and 10 studies (n = 32,864) were included. Our meta-analysis revealed that PAD significantly increased the risk of all-cause mortality (RR 2.15, 95 % CI 1.67–2.77, n = 32,864) and CV mortality (RR 2.99, 95 % CI 1.66-5.38, n = 31,794) in HD patients after multivariate adjustment. Subgroup analyses showed the study design and follow-up time might be two sources of heterogeneity.ConclusionPAD may be a prognostic marker of all-cause and CV mortality in HD patients. More attention should be paid to diagnosis and management of PAD in HD patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-016-0397-1) contains supplementary material, which is available to authorized users.
“…[43][44][45] Regarding markers of inflammation, a number of publications underlined their utility as markers of risk for PAD. [46][47][48] Based on this information, other components of the pentraxin class, such as pentraxin-3 or levels of matrix metalloproteinase, cellular adhesion molecules, interleukin-1 or interleukin-6 levels could have been added to the inflammatory panel to further investigate the relationship between inflammation, imagistic markers, and atherosclerosis.…”
Introduction:The burden of coronary artery disease (CAD) and peripheral vascular pathologies caused by atherosclerosis is constantly increasing. There is continuous research aiming to develop new methods that can evaluate the extent of atherosclerotic disease in different vascular beds, thus estimating global risk. Similar to carotid artery thickness, which is an established marker for increased cardiovascular risk and cerebrovascular disease, femoral intima-media thickness (f-IMT) may have the same role in case of peripheral arterial involvement. The aim of the study was determine whether f-IMT, determined at the level of the superficial femoral artery, is related to traditional risk factors, markers of peripheral vascular atherosclerosis and inflammation. Material and methods: Forty-six patients with known cardiovascular disease were included in the study. Demographical data, cardiovascular history, and risk factors were assessed. We determined metabolic parameters (uric acid, fasting glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides), renal function (creatinine and GFR), and inflammation status for all patients. Each patient underwent ultrasound examination of the superficial femoral artery, by which f-IMT was determined for right and left limbs. Ankle-brachial index was also calculated. Data from the low (f-IMT <0.75 mm) and high (f-IMT >0.75 mm) f-IMT groups were compared and correlation coefficients were determined in each groups for f-IMT in relation to the other parameters. Results: Mean age was 71.08 ± 9.78 years. 86.95% of the patients suffered from hypertension, 56.62% had coronary heart disease, and 21.73% had a history of stroke. More females had history of hypertension and CAD. The most prevalent cardiovascular risk factors were dyslipidemia (68.86%), diabetes (21.73%), and smoking (21.73%). There were significant differences between gender groups for total cholesterol levels (161.36 ± 25.04 mg/dL, in females, p = 0.02), creatinine values (1.04 ± 0.22 mg/dL, 95%CI 0.94-1.14 for males vs. 0.91 ± 0.23 mg/dL, 95%CI 0.81-1.00 for females, p = 0.018), and left f-IMT (0.87 ± 0.18 mm, 95%CI 0.79-0.95 for males vs. 0.75 ± 0.10 mm, 95%CI 0.70-0.79 for females, p = 0.0049). In the group with low f-IMT, a significant, reverse correlation was established between f-IMT, uric acid (r = -0.483, p = 0.042), and right ABI (r = -730, p = 0.0006). In the group with high f-IMT, age (r = 0.408, p = 0.031), fasting glucose (r = 0.407, p = 0.034), total cholesterol (r = 0.429, p = 0.02), HDL-cholesterol (r = -0.56, p = 0.0019), triglycerides (r = 0.45, p = 0.01), hs-CRP (r = 0.45, p = 0.01), and left ABI (r = -0.71, p <0.0001) showed a significant correlation to f-IMT. Conclusions: Increased femoral intima-media thickness is related to age, cardiovascular risk factors, and markers of peripheral arterial disease. Patients with higher f-IMT have a more augmented inflammatory status. Based on these correlations, in patients with cardiovascular disease, f-IMT could become a marker for increased cardi...
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