Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows

Kumar, Sanjeev; Srivastava, A. K.; Dumka, V. K.; Kumar, Naresh; Raina, Rajinder

doi:10.1007/s11259-010-9421-2

Cited by 9 publications

(6 citation statements)

References 14 publications

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“…Similarly, greater secretion of ceftriaxone into milk was also detected in cows with endometritis after IV administration, compared with results for control cows. 51 Finally, use of a population pharmacokinetic model revealed the need for a longer withdrawal interval than the FDAapproved withdrawal time 52 for flunixin in meat, which suggested a need for pharmacokinetic studies in both healthy and diseased animals.…”

Section: Discussionmentioning

confidence: 99%

Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis

Kissell

Leavens²,

Baynes³

et al. 2015

javma

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Section: Discussionmentioning

confidence: 99%

Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis

Kissell

Leavens²,

Baynes³

et al. 2015

javma

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“…In that regard, drug concentrations in milk derived from high-production quarters were significantly lower and depletion was more rapid than those from low-production quarters. Conversely, Kumar et al (2010) reported that ceftriaxone levels were lower and that CL was higher in diseased versus healthy cattle. A statistical analysis was not conducted to support this conclusion.…”

Section: Impact Of Disease As a Function Of Drug Classmentioning

confidence: 97%

“…Cephalosporin drug concentrations in milk were measured in two studies: intravenous ceftriaxone administered to healthy and diseased (endometritis) cows (Kumar et al, 2010) and intramammary infusion of ceftiofur hydrochloride to healthy and mastitic cattle (Han et al, 2017). Han's group did not observe any significant differences in either the milk or serum total ceftiofur concentrations as a function of infection.…”

Section: Impact Of Disease As a Function Of Drug Classmentioning

confidence: 99%

The Impact of Infection and Inflammation on Drug Metabolism, Active Transport, and Systemic Drug Concentrations in Veterinary Species

et al. 2020

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Within human medicine, it is recognized that the pharmacokinetics (PK) of many compounds can be altered by the presence of inflammation or infection. Research into the reason for these changes has identified pathways that can influence drug absorption, clearance, and tissue distribution. In contrast, far less is known about these relationships within the framework of veterinary medicine. Rather, most of the PK data generated in veterinary species employs healthy subjects, raising the question of whether these studies are founded on an assumption that healthy animal PK reflect that of the diseased animal population. Accordingly, there is a need to explore the PK changes that might be overlooked in studies that recruit only healthy animals to assesses drug PK. To meet this objective, we surveyed the published literature for studies focusing on the impact of disease on the dose-exposure relationships in food-producing and companion animal species. We found that, consistent with humans and laboratory species, both up-and downregulation of the various cytochrome isoenzymes and/or transporters have occurred in response to an increase in inflammatory mediators. These findings suggest that, as observed in human medicine, the potential for differences in the drug PK in healthy versus animal patients points to a need for acquiring a greater understanding of these changes and how they may influence the dose-exposureresponse relationships of veterinary pharmaceuticals. SIGNIFICANCE STATEMENTThis review delivers a much-needed summary of published information that provides insights into how disease and inflammation can influence the appropriateness of extrapolating laboratorybased dose-exposure-response relationships to what will occur in the actual veterinary patient. As part of this review, we also examine some of the method-associated issues to be considered when assessing the reported nature and magnitude of these changes.

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“…Pharmacokinetics of lincomycin has been conducted in dairy cattle (Weber et al1981), calves (Burrows et al 1983(Burrows et al , 1986, buffalo calves (Gouri et al 2014), pigs (Chaleva and Nquyen 1987;Nielsen and Gyrd-Hansen 1998), cats (Albarellos et al 2012(Albarellos et al , 2013 and chickens (El-Sayed et al 2015). Further, disease conditions are known to alter the disposition of antimicrobials (Kumar et al 2010;Burrows 1986). Fever is most common manifestations of infectious diseases and is reported to induce biochemical and physiological alterations in the cells (Van Miert 1987).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of lincomycin following intravenousadministration in febrile goats

Sharma

Dumka

2016

IJAR

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Disposition of antimicrobials is known to be altered during disease conditions and fever is one of the common manifestations of bacterial infections in animals. The disposition of lincomycin (10 mg/kg, IV) during Echerichia coli endotoxin-induced fever in goats followed two compartment open model and drug was detected in plasma up to 8 h. The high AUC (39.5±6.21 g.h/mL) indicated good antibacterial activity of lincomycin in goats. The volume of distribution and total body clearance were 3.35±0.45 L/kg and 0.28±0.03 L/h/kg, respectively. The long elimination half life 9.93± 2.83 h indicated persistence of drug for longer period in body. Lincomycin, is suggested to be repeated at 24 h interval for organisms sensitive to lincomycin having MIC up to 0.6 µg/mL for the treatment of bacterial infections manifested with fever in goats.

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Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows

Cited by 9 publications

References 14 publications

Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis

Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis

The Impact of Infection and Inflammation on Drug Metabolism, Active Transport, and Systemic Drug Concentrations in Veterinary Species

Pharmacokinetics of lincomycin following intravenousadministration in febrile goats

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