Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions

Albarellos, G. A.; Montoya, L.; Lupi, Martín P; Passini, Sabrina Mariela; Lorenzini, Paula Mercedes; Landoni, M. F.

doi:10.4081/vsd.2015.5742

Cited by 1 publication

(2 citation statements)

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“…[8][9][10][11][12][13][14][15][16] Moreover, cefazolin pharmacokinetic parameters in cats are very similar to those reported for cephalothin in this species. 26 The mean cefazolin tissue concentrations found in this study were relatively high and estimated tissue/ plasma ratio for all tissues were always less than unity. These results confirm that distribution of cefazolin is restricted to the vascular space and the extracellular fluid.…”

Section: Discussionmentioning

confidence: 49%

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Cefazolin pharmacokinetics in cats under surgical conditions

Albarellos

Montoya

Passini

et al. 2016

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to determine the plasma pharmacokinetic profile, tissue concentrations and urine elimination of cefazolin in cats under surgical conditions after a single intravenous dose of 20 mg/kg. Methods Intravenous cefazolin (20 mg/kg) was administered to nine young mixed-breed cats 30 mins before they underwent surgical procedures (ovariectomy or orchiectomy). After antibiotic administration, samples from blood, some tissues and urine were taken. Cefazolin concentrations were determined in all biological matrices and pharmacokinetic parameters were estimated. Results Initial plasma concentrations were high (C, 134.80 ± 40.54 µg/ml), with fast and moderately wide distribution (distribution half-life [t] 0.16 ± 0.15 h; volume of distribution at steady state [V] 0.29 ± 0.10 l/kg) and rapid elimination (body clearance [Cl], 0.21 ± 0.06 l/h/kg; elimination half-life [t], 1.18 ± 0.27 h; mean residence time 1.42 ± 0.36 h). Thirty to 60 mins after intravenous administration, cefazolin tissue concentrations ranged from 9.24 µg/ml (subcutaneous tissue) to 26.44 µg/ml (ovary). The tissue/plasma concentration ratio ranged from 0.18 (muscle) to 0.58 (ovary). Cefazolin urine concentrations were high with 84.2% of the administered dose being eliminated in the first 6 h postadministration. Conclusions and relevance Cefazolin plasma concentrations remained above a minimum inhibitory concentration of ⩽2 µg/ml up to 4 h in all the studied cats. This suggests that a single intravenous dose of 20 mg/kg cefazolin would be adequate for perioperative prophylactic use in cats.

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