Plasma Phospholipase A2 Activity in Nephrectomized Rats and the Question of Renin Inhibition

Dh, Osmond; Pa, McFadzean; Lj, Ross; Cinader, B.

doi:10.3181/00379727-144-37722

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1975

1980

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“…The renin-inhibitory role of a lysophospholipid of renal origin (Smeby et al, 1967) is now questioned by the results of the experiments of Osmond et al (1973). Haemoglobin can exert an inhibitory effect (Workman et al, 1974), but it is present in plasma at far too low a concentration to account for any significant portion of plasma's inhibitory effect.…”

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confidence: 99%

α-1-Anti-trypsin, an inhibitor of renin

Eid¹,

Cooreman²,

Lauwers³

1976

Biochemical Journal

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A naturally occurring competitive inhibitor of pig kidney renin has been identified in human plasma. The inhibitor was shown to be alpha-1 anti-trypsin and the effect in vitro on the renin activity was examined. The slope in the Hill plot is compatible with the assumption of one-site competitive inhibition. Other proteinase inhibitors, such as alpha-2-macroglobulin and C1 inactivator, however, have no inhibitory effect on the renin-angiotensinogen reaction.

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confidence: 99%