Plasma polymer film designs through the eyes of ToF-SIMS

Bernard, Laetitia; Rupper, Patrick; Faccio, Greta; Hegemann, Dirk; Scholder, Olivier; Heuberger, Manfred; Maniura‐Weber, Katharina; Vandenbossche, Marianne

doi:10.1116/1.5016046

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…The very low fluorescence obtained for the CO/CN 3:5 films can also be explained by recent observations made on gradient-containing coatings: the terminal CO layers of increasing thickness were found to exhibit an increasing tendency for motility and reorganization, thus emphasizing the importance of the terminal film thickness and composition [16][17][18]. The very low GFP adsorption on CO/CN structures with a CO layer thickness C 3 nm has also been recognized in a previous study on the micro-patterning of bi-functional PPFs [32,57].…”

Section: Protein Characterization and Protein Adsorption Onto Co/cn S...supporting

confidence: 64%

“…8). Note that the overall fluorescence intensities were moderate, since no linkers have been used in order to directly spot the surface properties of the PPFs [57]. Hence, a comparison with literature data regarding the performance of the examined PPFs with respect to high (or low) protein adsorption is complicated.…”

Section: Protein Characterization and Protein Adsorption Onto Co/cn S...mentioning

confidence: 99%

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Near-Surface Structure of Plasma Polymer Films Affects Surface Behavior in Water and its Interaction with Proteins

Vandenbossche

Gunkel‐Grabole

Car

et al. 2018

Plasma Chem Plasma Process

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Using low pressure plasma polymerization, nano-scaled oxygen-rich plasma polymer films (CO) were deposited onto pristine silicon wafers as well as on nitrogencontaining plasma polymer (CN) model surfaces. We investigate the influence of the nature of the substrate as well as a potential sub-surface effect emerging from the buried CO/CN interface, just nanometers below the surface. X-ray Photoelectron Spectroscopy and Timeof-Flight Secondary Ion Mass Spectrometry revealed two important phenomena that occurred during the deposition of the terminal CO layer: (1) a strong degree of oxidation, already for 1 nm nominal thickness, and (2) a gradual transition in chemical composition between the two layers, clearly indicating that effectively a vertical chemical gradient results, even when a two-step coating process was applied. Such terminal gradient film structures were used to study film stability in aqueous environments. Molecular rearrangements were scrutinized in the top-surface in contact with water and we found that the top-surface chemistry and wetting properties of the oxygen-rich termination layer matched those of thick CO reference coatings. Nevertheless, the adsorption of green fluorescent protein (GFP) was observed to be sensitive to the CO terminal layer thickness. Namely, an enhanced protein adsorption was observed for 1-2 nm thick CO layers on CN, whereas a significantly reduced protein adsorption was seen on C 3 nm thick CO terminal layers. We

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Section: Protein Characterization and Protein Adsorption Onto Co/cn S...supporting

confidence: 64%

Section: Protein Characterization and Protein Adsorption Onto Co/cn S...mentioning

confidence: 99%

Near-Surface Structure of Plasma Polymer Films Affects Surface Behavior in Water and its Interaction with Proteins

Vandenbossche

Gunkel‐Grabole

Car

et al. 2018

Plasma Chem Plasma Process

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“…Therefore, a base layer fully covering the Au surface (above ∼4 nm a‐C:H:O thickness) is required to enable a well‐defined surface composition, low aging effects, and precise control of the surface termination process used to stabilize surface functional groups via a vertical chemical gradient. For such conditions a distinct transition from the stabilizing base layer to the functional termination layer extending over ∼1 nm had been observed by angle‐resolved XPS and ToF‐SIMS . Hence, the change in plasma conditions from depositing to more etching conditions (corresponding to a drop in deposition rate from 6.0 to 1.2 nm min −1 ) supported the formation of the well‐defined top layer.…”

Section: Resultsmentioning

confidence: 81%

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Hegemann

Индутный

Zajı́čková

et al. 2018

Plasma Processes & Polymers

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Stable surface functionalization is required in many applications such as in biosensing. For this purpose, hydrocarbon‐based plasma polymer films (PPFs) were investigated by controlling cross‐linking and film structure at the nanoscale, while functional groups were incorporated using a CO2/C2H4 low pressure plasma. In particular, an oxygen‐rich termination layer of 1 nm (top layer) was gradually deposited onto a more cross‐linked PPF (base layer) with varying thickness (<20 nm) yielding highly stable yet functional a‐C:H:O films as compared to conventional oxygen‐rich PPFs. Such stabilized nano‐layers provided a homogeneous functionalization of Au‐coated (flat) biochips as used for immunosensing as well as of nanostructured Au‐coated surfaces explored for enhanced biosensing. The used periodic grating coated by the highly stable a‐C:H:O nano‐layer can be adjusted to the required environmental refractive index range yielding a distinct sensitivity enhancement for biosensing.

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“…Collectively, this review summarizes the principles at the basis of plasma deposition and highlights recent progress made in understanding the unique chemistry and reactivity of coatings deposited by this method [147]. We then demonstrate how carefully designed plasma polymer films can serve the purpose of fundamental research and biomedical applications.…”

Section: Discussionmentioning

confidence: 99%

Perspective on Plasma Polymers for Applied Biomaterials Nanoengineering and the Recent Rise of Oxazolines

MacGregor

Vasilev

2019

Materials

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Plasma polymers are unconventional organic thin films which only partially share the properties traditionally attributed to polymeric materials. For instance, they do not consist of repeating monomer units but rather present a highly crosslinked structure resembling the chemistry of the precursor used for deposition. Due to the complex nature of the deposition process, plasma polymers have historically been produced with little control over the chemistry of the plasma phase which is still poorly understood. Yet, plasma polymer research is thriving, in par with the commercialisation of innumerable products using this technology, in fields ranging from biomedical to green energy industries. Here, we briefly summarise the principles at the basis of plasma deposition and highlight recent progress made in understanding the unique chemistry and reactivity of these films. We then demonstrate how carefully designed plasma polymer films can serve the purpose of fundamental research and biomedical applications. We finish the review with a focus on a relatively new class of plasma polymers which are derived from oxazoline-based precursors. This type of coating has attracted significant attention recently due to its unique properties.

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Plasma polymer film designs through the eyes of ToF-SIMS

Cited by 7 publications

References 55 publications

Near-Surface Structure of Plasma Polymer Films Affects Surface Behavior in Water and its Interaction with Proteins

Near-Surface Structure of Plasma Polymer Films Affects Surface Behavior in Water and its Interaction with Proteins

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Perspective on Plasma Polymers for Applied Biomaterials Nanoengineering and the Recent Rise of Oxazolines

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