Plasma-Polymerized Phlorotannins and Their Enhanced Biological Activities

Kim, Hyun‐Joo; Yong, Hae In; Lee, Byong Won; Park, Sanghoo; Baek, Ki Ho; Kim, Tae Hoon; Jo, Cheorun

doi:10.1021/acs.jafc.9b07077

Cited by 18 publications

(6 citation statements)

References 42 publications

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“…Phlorotannins have been studied for their potential health effects. Reported bioactivities include antioxidant [ 198 ], antidiabetic [ 199 ], anticancer [ 200 ], antihypertensive [ 201 ], anti-inflammatory [ 202 ], antiviral [ 203 ], neuroprotective [ 204 ], antimicrobial [ 205 ], and prebiotic activities [ 10 , 206 , 207 ].…”

Section: Discussionmentioning

confidence: 99%

Seaweed Components as Potential Modulators of the Gut Microbiota

2021

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Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Polysaccharides such as fucoidan, laminarin, alginate, ulvan and porphyran are unique to seaweeds. Several studies have shown their potential to act as prebiotics and to positively modulate the gut microbiota. Prebiotics enhance bacterial populations and often their production of short chain fatty acids, which are the energy source for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, and induce apoptosis of colon cancer cells. The oral bioaccessibility and bioavailability of seaweed components is also discussed, including the advantages and limitations of static and dynamic in vitro gastrointestinal models versus ex vivo and in vivo methods. Seaweed bioactives show potential for use in prevention and, in some instances, treatment of human disease. However, it is also necessary to confirm these potential, therapeutic effects in large-scale clinical trials. Where possible, we have cited information concerning these trials.

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Section: Discussionmentioning

confidence: 99%

Seaweed Components as Potential Modulators of the Gut Microbiota

2021

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“…Oxidative reactions could produce a phlorotannin isomer by the structural recombination of molecules, most likely through intra-or intermolecular bonding [29]. Although the different TPCs between different phlorotannin isomers are unclear, polymer-ized phlorotannins showed lower TPC values than the monomeric unit phloroglucinols under the Folin-Ciocalteu method [30]. The Folin-Ciocalteu method, widely used in phenolic compound studies, including the current study, was designed to measure the total concentration of phenolic hydroxyl groups in the extract and fractions based on an oxidation-reduction reaction [31].…”

Section: Change Of Total Phlorotannin Contents Through Uva and Heat Exposurementioning

confidence: 98%

Effects of UV and Heating on the Stability of Fucoxanthin, Total Phlorotannin and Total Antioxidant Capacities in Saccharina japonica Ethanol Extract and Solvent Fractions

et al. 2021

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The brown alga Saccharina japonica is widely consumed in Asian countries, and post-harvest drying methods such as sun drying and oven drying are commonly used to extend the shelf life of S. japonica. Thus, the present study analyzed the ethanol extract and organic solvent fractions of S. japonica to examine the effects of UVA and heating on certain bioactive compounds (fucoxanthin, phlorotannin compounds, and total antioxidants) during the drying process. The fucoxanthin contents in the ethanol extract and different solvent fractions significantly decreased in response to UVA. However, fucoxanthin in the ethanol extract and other fractions showed resistance to thermal treatment. It is noteworthy that the total phlorotannin content (TPC) in the ethanol extract and all fractions showed an approximately 2.5-fold increase upon UVA radiation. The TPC also increased in all samples exposed to high temperatures, except for those in the chloroform fraction. The total antioxidant capacity (TAC) also exhibited significant increases in a pattern similar to the TPC. The findings demonstrate that UVA exposure and heating stimulated the degradation of fucoxanthin while it increased the TPC and TAC in the extract and fractions of S. japonica.

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“…Therefore, phlorotannins could be utilized as a natural antioxidant in the functional foods, pharmaceuticals, and cosmetics industries (Li et al, 2009). Besides, phlorotannins also exhibit cytotoxic (Shoeib et al, 2004), anti-inflammatory (Dutot et al, 2012, type-2 diabetic suppressing (Yan et al, 2019), UV-protective, chemopreventive activities and heavy metal detoxify activities (Kim et al, 2020;Hamed et al, 2015), as well as antimicrobial activities by attacking the proteins of microorganisms (bacterial inhibition) (Gupta and Abu-Ghannam, 2011b).…”

Section: Phlorotanninsmentioning

confidence: 99%

Novel marine bioactives: application in functional foods, nutraceuticals, and pharmaceuticals

Shahidi

Santhiravel

2022

Journal of Food Bioactives

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Functional food, nutraceutical, and pharmaceutical applications of natural products have gained growing attention as there is increasingly awareness of the association between bioactive compounds and improved health. Recently, food and biomedical scientists have focused more on marine resources to isolate bioactives since the marine ecosystem comprises unexploited resources with a wide range of organisms. Marine species produce a wide range of natural products, such as polysaccharides, peptides, polyunsaturated lipids, phenolic compounds, and pigments, with unique structures and diverse biological activities due to their extreme living environments. These active molecules reduce the risk of chronic disease and improve health by exhibiting antioxidant, anticancer, anti-inflammatory, antimicrobial, antidiabetic, anti-obesity, antihypertensive, cardioprotective, and neuroprotective activities. This review summarizes the recent discoveries of bioactive compounds from marine invertebrates (sponges, cnidarians, echinoderms, molluscs, ascidians, and crustaceans), fishes, seaweeds, and marine microorganisms and their potential for functional foods, nutraceuticals, and pharmaceuticals applications.

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Plasma-Polymerized Phlorotannins and Their Enhanced Biological Activities

Cited by 18 publications

References 42 publications

Seaweed Components as Potential Modulators of the Gut Microbiota

Seaweed Components as Potential Modulators of the Gut Microbiota

Effects of UV and Heating on the Stability of Fucoxanthin, Total Phlorotannin and Total Antioxidant Capacities in Saccharina japonica Ethanol Extract and Solvent Fractions

Novel marine bioactives: application in functional foods, nutraceuticals, and pharmaceuticals

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