Plasma Procalcitonin Is Useful for Predicting the Severity of Acute Cholecystitis

Şakalar, Şaben; Özakın, Engin; Çevik, Arif Alper; Acar, Nurdan; Doğan, Serkan; Kaya, Filiz Baloğlu; Kara, Taylan

doi:10.1155/2020/8329310

Cited by 7 publications

(11 citation statements)

References 29 publications

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“…Yuzbasioglu described a positive correlation between PCT and CRP and leukocyte levels. Sakalar et al also showed that PCT level was strongly correlated to acute cholecystitis severity [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Management of Intra-Abdominal Infections: The Role of Procalcitonin

Tian,

Agnoletti,

Ansaloni

et al. 2023

Antibiotics

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Patients with intra-abdominal sepsis suffer from significant mortality and morbidity. The main pillars of treatment for intra-abdominal infections are (1) source control and (2) early delivery of antibiotics. Antibiotic therapy should be started as soon as possible. However, the duration of antibiotics remains a matter of debate. Prolonged antibiotic delivery can lead to increased microbial resistance and the development of nosocomial infections. There has been much research on biomarkers and their ability to aid the decision on when to stop antibiotics. Some of these biomarkers include interleukins, C-reactive protein (CRP) and procalcitonin (PCT). PCT’s value as a biomarker has been a focus area of research in recent years. Most studies use either a cut-off value of 0.50 ng/mL or an >80% reduction in PCT levels to determine when to stop antibiotics. This paper performs a literature review and provides a synthesized up-to-date global overview on the value of PCT in managing intra-abdominal infections.

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Section: Discussionmentioning

confidence: 99%

Management of Intra-Abdominal Infections: The Role of Procalcitonin

Tian,

Agnoletti,

Ansaloni

et al. 2023

Antibiotics

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“…There are also publications that examine plasma procalcitonin levels to determine the prognosis of acute cholecystitis. It was shown in the study of Sakalar et al[ 17 ] with 95 patients and in the study of Yuzbasioglu et al[ 18 ] with 200 patients, it was shown that procalcitonin levels determined the severity of acute cholecystitis effectively and significantly.…”

Section: Discussionmentioning

confidence: 99%

Prognostic effect of Nesfatin-1 on the diagnosis and staging of acute cholecystitis

Tekin¹

2021

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Gallbladder diseases are an important health concern affecting approximately 20% of the population in developed countries. Acute cholecystitis is the most common complication of gallstones. The aim of our study is to determine the use of Nesfatin-1, which is an easily applicable and fast resulting and is thought to have an association with inflammatory events, in the diagnosis and grading of acute cholecystitis. METHODS: Patients who admitted and were hospitalized and treated with the acute cholecystitis diagnosis in İstanbul Training and Research Hospital between July 1, 2020, and December 1, 2020, were included in the study. The patients were divided in threemain groups as mild, moderate, and severe according to Tokyo Guidelines 2018 based on their routine blood tests and imaging results. All patients who are included in the study were tested for their blood leukocyte, neutrophil, lymphocyte, Nesfatin-1 levels, and neutrophil/lymphocyte ratios within the first 24 h of their hospitalization. RESULTS: With at least 15 patients in each group, 61 volunteers in total were included in the study as healthy volunteers, mild, moderate, and severe cholecystitis. The average age of the participants were 58.11±19.76 years. About 47.54% of the participants were female and 52.46% weremale. In the study, Nesfatin-1 levels in the patient groups were found to be lower than the control group. In the subgroup analyzes, Nesfatin-1 values in the middle patient group were found to be significantly lower than the control group; however, there was no statistically significant relationship between the severity of the disease and Nesfatin-1. CONCLUSION: Nesfatin-1 may guide the clinician for the diagnosis of the disease; however, no significant relationship was found between Nesfatin-1 and the severity or stage of the disease.

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“…Seven full texts were reviewed, of which four articles were eligible [25,33,34,39]. One additional article was identified from reviewing references of eligible articles [36] Therefore, the final analysis included five articles (four prospective cohort studies and one retrospective study).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Thus, it was not included within the guidelines. Since then, there have been studies evaluating the role of PCT in diagnosis, severity stratification, and/or outcomes in AC [33,34]. It is timely that a comprehensive review of existing evidence is conducted to shed light if PCT could be included in AC management.…”

Section: Introductionmentioning

confidence: 99%

Should Procalcitonin Be Included in Acute Cholecystitis Guidelines? A Systematic Review

et al. 2023

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Background and Objectives: Acute cholecystitis (AC) is a common surgical emergency. Recent evidence suggests that serum procalcitonin (PCT) is superior to leukocytosis and serum C-reactive protein in the diagnosis and severity stratification of acute infections. This review evaluates the role of PCT in AC diagnosis, severity stratification, and management. Materials and Methods: PubMed, Embase, and Scopus were searched from inception till 21 August 2022 for studies reporting the role of PCT in AC. A qualitative analysis of the existing literature was conducted. Results: Five articles, including 688 patients, were included. PCT ≤ 0.52 ng/mL had fair discriminative ability (Area under the curve (AUC) 0.721, p < 0.001) to differentiate Grade 1 from Grade 2–3 AC, and PCT > 0.8 ng/mL had good discriminatory ability to differentiate Grade 3 from 1–2 AC (AUC 0.813, p < 0.001). PCT cut-off ≥ 1.50 ng/mL predicted difficult laparoscopic cholecystectomy (sensitivity 91.3%, specificity 76.8%). The incidence of open conversion was higher with PCT ≥ 1 ng/mL (32.4% vs. 14.6%, p = 0.013). A PCT value of >0.09 ng/mL could predict major complications (defined as open conversion, mechanical ventilation, and death). Conclusions: Current evidence is plagued by the heterogeneity of small sample studies. Though PCT has some role in assessing severity and predicting difficult cholecystectomy, and postoperative complications in AC patients, more evidence is necessary to validate its use.

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Plasma Procalcitonin Is Useful for Predicting the Severity of Acute Cholecystitis

Cited by 7 publications

References 29 publications

Management of Intra-Abdominal Infections: The Role of Procalcitonin

Management of Intra-Abdominal Infections: The Role of Procalcitonin

Prognostic effect of Nesfatin-1 on the diagnosis and staging of acute cholecystitis

Should Procalcitonin Be Included in Acute Cholecystitis Guidelines? A Systematic Review

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