Plasma Profiling of Acute Myeloid Leukemia With Fever‐ and Infection‐Related Complications During Chemotherapy‐Induced Neutropenia

Abstract

BackgroundAcute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.AimsWe explored associations between plasma protein levels and fever‐ and infection‐related complications in 26 AML patients during chemotherapy‐induced neutropenia.Material and MethodsLongitudinal plasma profiling was conducted using data‐dependent mass spectrometry analysis.ResultsMass spectrometry‐based plasma profiling data correlated well with laboratory parameters, including C‐reactive protein, and revealed a broader inflammation protein network associated with fever‐ and infection‐related complications.Discussion and ConclusionThese data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.