Plasma prolactin, human chorionic gonadotropin, estradiol, testosterone, and progesterone in the ovarian hyperstimulation syndrome

Yuen, Basil Ho; McComb, Peter F.; Sy, Lydia; Lewis, Joyce; Cannon, Wendy

doi:10.1016/0002-9378(79)90686-0

Cited by 43 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High PRL levels have been found in women undergoing ovarian stimulation with either hMG (17) or human pituitary gonadotropin (18); the increase in PRL occurred in parallel with an increase in estradiol in these studies. It was suggested that since estrogens are potent stimulators of PRL secretion (19), it is conceivable that the high serum estradiol levels found during hMG treatment may be the cause of the correspondingly high serum PRL levels.…”

Section: Discussionmentioning

confidence: 91%

“…Another possible explanation for this difference may be the use of hMG to induce ovulation. Serum levels of FSH in hMG-induced cycles were shown to be rela- tively high, ranging from 20-30 mlU/ml (16,17). Similarly, the detection of high levels of hCG in the FF probably stems from the high serum concentration after the administration of a large ovulatory dose of hCG.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Gonadotropin and Prolactin Levels in Follicular Fluid of Human Ova Successfully Fertilized in Vitro

Laufer

Botero-Ruiz

DeCherney

et al. 1984

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

Follicular fluid (FF) and oocytes were obtained from 94 follicles of 36 women for fertilization in vitro. Ovulation was induced with human menopausal gonadotropin, and follicular aspiration was performed 36 h after an ovulatory injection of hCG. The concentrations of immunoreactive hCG, FSH, and PRL were correlated with the degree of maturation of the oocyte-corona-cumulus complex mass (OCCC), fertilization, rate of cleavage, and the incidence of pregnancy after embryo transfer. Immature OCCC were derived from follicles that contained significantly lower levels of FSH than those from which intermediate and mature OCCC were derived (5.2 +/- 0.6 vs. 11.1 +/- 1.2 mlU/ml; P less than 0.05). FF from oocytes that were successfully fertilized contained higher levels of both hCG and FSH than FF surrounding oocytes that did not fertilize (136.7 +/- 8.7 vs. 108.5 +/- 10.3 mlU/ml hCG; 10.55 +/- 0.6 vs. 5.3 +/- 0.8 mIU FSH, respectively). There was no correlation between early embryonic growth rate and FF concentrations of FSH, hCG, and PRL. Ova reaching the two-cell stage 40 h after fertilization in vitro were associated with the same FF concentrations of FSH, hCG, and PRL as those that cleaved to the four-cell stage. The PRL concentration in FF was significantly higher in mature fertilized ova and in fertilized ova that were associated with a successful pregnancy. It is suggested that the intrafollicular concentration of FSH is associated with the degree of mucification of the OCCC, but FF levels of both FSH and hCG are associated with successful fertilization. High levels of PRL in FF were associated with successful pregnancy and may imply a role of this hormone in oocyte maturation.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Gonadotropin and Prolactin Levels in Follicular Fluid of Human Ova Successfully Fertilized in Vitro

Laufer

Botero-Ruiz

DeCherney

et al. 1984

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

show abstract

“…1965;Neuwirth er al. 1965;Tyack & Ellis 1971: Engel et al 1972Schenker & Polishuk 1975Shapiro et al 1977Yuen et al 1979;Thaler el al. 1981).…”

Section: Discussionmentioning

confidence: 97%

“…It must therefore be assumed that her ovaries were hypersensitive to a relatively low level of hCG as neither the dose administered nor the endogenous levels were high. Normal hCG levels have been found in other cases of iatrogenic hyperstimulation (Schenker & Weinstein 1978;Yuen et al 1979) in contrast to the 'hyperstimulation' that occurs in association with a molar pregnancy. It is possible that her ovarian hypersensitivity was related to hypothyroidism; it has been shown that the ovaries of hypothyroid rats are hypersensitive to hCG (Adams & Leathem 1965).…”

Section: Discussionmentioning

confidence: 99%

Severe ovarian hyperstimulation after clomiphene citrate in a hypothyroid patient

Morgan

Paredes

Lachelin

1983

BJOG

View full text Add to dashboard Cite

“…Hyperprolactinemia is associated with luteal phase defects. 153 High serum prolactin levels have been reported in women undergoing ovarian stimulation with hMG 154 and under all types of anesthesia used for IVF. 155 Consequently, a relative hyperprolactinemic state in IVF patients may contribute to a relative corpus luteum deficiency.…”

Section: The Luteal Phase and Gestationmentioning

confidence: 99%

In Vitro Fertilization: State of the Art

Laufer¹,

Tarlatzis²,

Naftolin³

1984

Semin Reprod Med

View full text Add to dashboard Cite

Plasma prolactin, human chorionic gonadotropin, estradiol, testosterone, and progesterone in the ovarian hyperstimulation syndrome

Cited by 43 publications

References 9 publications

Gonadotropin and Prolactin Levels in Follicular Fluid of Human Ova Successfully Fertilized in Vitro

Gonadotropin and Prolactin Levels in Follicular Fluid of Human Ova Successfully Fertilized in Vitro

Severe ovarian hyperstimulation after clomiphene citrate in a hypothyroid patient

In Vitro Fertilization: State of the Art

Contact Info

Product

Resources

About