Plasma protein binding of nitroxynil in several species

Alvinerie, M.; Floc'h, Roselyne; Galtier, P.

doi:10.1111/j.1365-2885.1991.tb00819.x

Cited by 18 publications

(16 citation statements)

References 9 publications

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“…This is explained by their strong plasma protein binding which is more than 99% for salicylanilides (Mohammed-Ali and Bogan 1987, Rothwell and Sangster 1997, Stove 1998, Rothwell et al 2000 and 98% for nitroxynil (Alvinerie et al 1995).…”

Section: Discussionmentioning

confidence: 99%

Clastogenic Effects of the Fasciolicides Closantel and Nitroxynil on Mice Somatic and Germ Cells

Donya

Hassan

2007

CYTOLOGIA

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Summary Salicylanilide (Closantel) and halogenated phenol (Nitroxynil) have been reported to be an active fasciolocidal agents used in human and in farm animals. of chromosomal aberrations in diakinesis-metaphase I spermatocytes increased in a dose dependent manner and were found to be statistically significant with the 2 drugs. The 2 fasciolicides induced a signifycant percentage of sperm-shape abnormalities. The highest doses induced 12.74Ϯ0.49 and 7.02Ϯ0.13 (pϽ0.01) for closantel and nitroxynil respectively, compared to the control. In conclusion, the 3 cytogenetic parameters used to evaluate the effect of Closantel and Nitroxynil revealed that the 2 fasciolicides have a clastogenic effect on mice somatic and germ cells in vivo studies.

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Section: Discussionmentioning

confidence: 99%

Clastogenic Effects of the Fasciolicides Closantel and Nitroxynil on Mice Somatic and Germ Cells

Donya

Hassan

2007

CYTOLOGIA

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“…Fasciolosis is an important zoonotic disease [38]. These leaf-shaped flatworms are generally characterised by the tissues they infect such as the liver, lung, intestine and blood [39]. The intermediate host is a mud snail called Lymnea truncatula.…”

Section: Antitrematodal Drugsmentioning

confidence: 99%

“…It is also used to control Hemonchus contortus in sheep, Oesophagostomum species, Parafilaria bovicola and Bunostomum species in both sheep and cattle. Nitroxynil acts by producing a rapid spastic paralysis of the flukes [40,41] causes severe disruption of the tegument of Fasciola hepatica [39]. Nitroxynil is available as oral, intraruminal, subcutaneous, intramuscular preparations.…”

Section: Nitroxynilmentioning

confidence: 99%

Anthelmintics and their Application in Veterinary Medicine

Mm¹

2017

RMES

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“…This is due to its strong plasma protein binding which is more than 98% for this compound (Alvinerie et al, 1995). The selective mode of action of this highly protein-bound anthelmintic may be explained, in part, by its effect against bloodsucking parasites, concentrating the anthelmintic in the parasite (without the high tissues levels being produced in the host).…”

Section: Introductionmentioning

confidence: 99%

Research of nitroxynil residues in bovine milk following a single administration in the dry period by ultra-performance liquid chromatography tandem mass spectrometry

et al. 2013

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). Thirty-five pregnant dairy cows were treated in this study with nitroxynil (340 mg/mL solution for injection) at the recommended dose of 10 mg/kg body weight at the start of the dry period, i.e. 53 to 74 days before the expected calving. Calving occurred between 43 days and 79 days after treatment. The concentrations of NIT in the milk were monitored for up to 120 days after calving. NIT residues were extracted using acetonitrile; magnesium sulfate and sodium chloride were added to induce liquid-liquid partitioning and purified by dispersive solid phase extraction for clean-up. NIT was detected by ultra high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) in negative ionization mode. The highest concentrations of this drug were found in two animals at the first milking, 48 and 53 day post treatment with levels of 362 and 657 µg kg -1 , respectively. NIT residues were below the limit of detection of the method (0.24 µg/kg -1 ) between 67 and 106 day post-treatment. Following calving, residues rapidly depleted in animals and were non-detectable from 10 to 38 days post-calving. In particular, in all animals milk resulted compliant (<20 µg/kg −1 ) three days post partum.

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Plasma protein binding of nitroxynil in several species

Cited by 18 publications

References 9 publications

Clastogenic Effects of the Fasciolicides Closantel and Nitroxynil on Mice Somatic and Germ Cells

Clastogenic Effects of the Fasciolicides Closantel and Nitroxynil on Mice Somatic and Germ Cells

Anthelmintics and their Application in Veterinary Medicine

Research of nitroxynil residues in bovine milk following a single administration in the dry period by ultra-performance liquid chromatography tandem mass spectrometry

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