Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome*

Aman, Jurjan; Heijden, M. van der; Lingen, Arthur van; Girbes, Armand R. J.; Amerongen, Geerten P. van Nieuw; Hinsbergh, Victor W.M. van; Groeneveld, A. B. Johan

doi:10.1097/ccm.0b013e3181feb46a

Cited by 69 publications

(45 citation statements)

References 35 publications

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“…Regardless of this threshold, our results suggest that LV diastolic function contributes to the development of PGD. While previous work suggested that plasma albumin is inversely related to pulmonary vascular permeability in patients at risk for acute lung injury (57,58), the association between diastolic function and PGD was not affected by albumin level in our study.…”

Section: Discussioncontrasting

confidence: 52%

Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant

Porteous

Kirkpatrick

et al. 2016

Am J Respir Crit Care Med

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Rationale: Primary graft dysfunction (PGD) is a significant cause of early morbidity and mortality after lung transplant and is characterized by severe hypoxemia and infiltrates in the allograft. The pathogenesis of PGD involves ischemia-reperfusion injury. However, subclinical increases in pulmonary venous pressure due to left ventricular diastolic dysfunction may contribute by exacerbating capillary leak.Objectives: To determine whether a higher ratio of early mitral inflow velocity (E) to early diastolic mitral annular velocity (é), indicative of worse left ventricular diastolic function, is associated with a higher risk of PGD.Methods: We performed a retrospective cohort study of patients in the Lung Transplant Outcomes Group who underwent bilateral lung transplant at our institution between 2004 and 2014 for interstitial lung disease, chronic obstructive pulmonary disease, or pulmonary arterial hypertension. Transthoracic echocardiograms obtained during evaluation for transplant listing were analyzed for E/é and other measures of diastolic function. PGD was defined as Pa O 2 /FI O 2 less than or equal to 200 with allograft infiltrates at 48 or 72 hours after reperfusion. The association between E/é and PGD was assessed with multivariable logistic regression.Measurements and Main Results: After adjustment for recipient age, body mass index, mean pulmonary arterial pressure, and pretransplant diagnosis, higher E/é and E/é greater than 8 were associated with an increased risk of PGD (E/é odds ratio, 1.93; 95% confidence interval, 1.02-3.64; P = 0.04; E/é .8 odds ratio, 5.29; 95% confidence interval, 1.40-20.01; P = 0.01).Conclusions: Differences in left ventricular diastolic function may contribute to the development of PGD. Future trials are needed to determine whether optimization of left ventricular diastolic function reduces the risk of PGD.

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Section: Discussioncontrasting

confidence: 52%

Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant

Porteous

Kirkpatrick

et al. 2016

Am J Respir Crit Care Med

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“…Large number of the studies on this issue have focused on ICU adult patients generally and specific groups of patients with a variety of pathologic conditions. 8 However, there is a paucity of data on the incidence and significance of hypoalbuminemia in critically ill children admitted to intensive care unit.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hypoalbuminemia as a Predictor of Clinical Outcome in Critically Ill Children in Alexandria University Children's Hospital

Moustafa¹

2018

jmscr

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“…1 Besides hypervolemia and heart failure, high level of inflammation in ESRD patients contributes to lung congestion due to microvascular lung disease, provoking capillary leakage. 2,3 Lung congestion is a strong prognostic marker of cardiac events and death among ESRD patients submitted to HD. HD patients with severe congestion have a 4.2-fold higher risk of death and a 3.2-fold higher risk of cardiac events, like myocardial infarction, angina, heart failure and arrhythmia.…”

Section: Introductionmentioning

confidence: 99%

Variables associated with lung congestion as assessed by chest ultrasound in diabetics undergoing hemodialysis

Santos¹,

Neto²,

Carneiro³

et al. 2017

Jornal Brasileiro De Nefrologia

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Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome*

Cited by 69 publications

References 35 publications

Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant

Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant

Evaluation of Hypoalbuminemia as a Predictor of Clinical Outcome in Critically Ill Children in Alexandria University Children's Hospital

Variables associated with lung congestion as assessed by chest ultrasound in diabetics undergoing hemodialysis

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