Plasma proteins associated with circulating carotenoids in Nepalese school-aged children

Eroglu, Abdulkerim; Schulze, Kerry; Yager, James D.; Cole, Robert N.; Christian, Parul; Lee, Sun Eun; Wu, Lee; Khatry, Subarna K.; Groopman, John D.; West, Keith P.

doi:10.1016/j.abb.2018.03.025

Cited by 16 publications

(11 citation statements)

References 57 publications

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“…e distribution volume obtained in this work was 3.18 L, which is related to compounds that bind strongly with plasma proteins as albumin [44], reducing its free content in blood. It correlates with the previous works which described that crocetin binds to albumin [45,46] and other human serum proteins [47]. After 3 h of administration, crocetin ceased to be detected, obtaining a plasmatic half-life of 0.85 ± 0.04 h and a clearance of 2.70 ± 0.14 L/h.…”

Section: Discussionsupporting

confidence: 90%

Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract

Almodóvar¹,

Briskey

Rao³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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There are few studies about the pharmacokinetics of the low-molecular mass carotenoids crocetin or crocin isomers from saffron (Crocus sativus L.). None has been performed with a galenic preparation of a standardised saffron extract. The aim of the present research work was to study the effect of in vitro digestion process on the main bioactive components of saffron extract tablets and the corresponding pharmacokinetic parameters in humans. Pharmacokinetics were calculated collecting blood samples every 30 min during the first 3 h and at 24 h after administration of two different concentrations (56 and 84 mg of the saffron extract) to 13 healthy human volunteers. Additionally, an in vitro digestion process was performed in order to determine the bioaccessibility of saffron main bioactive compounds. Identification and quantification analysis were performed by HPLC-PAD/MS. Digestion resulted in 40% of bioaccesibility for crocin isomers, whereas, safranal content followed an opposite trend increasing about 2 folds its initial concentration after the digestion process. Crocetin in plasma was detected in a maximum concentration (Cmax) in blood between 60 and 90 min after oral consumption with dose-dependent response kinetics, showing that crocin isomers from galenic preparation of saffron extract are rapidly transformed into crocetin. The results showed that this tested galenic form is an efficient way to administer a saffron extract, since the observed crocetin Cmax was similar and more quickly bioavailable than those obtained by other studies with much higher concentrations of crocetin.

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Section: Discussionsupporting

confidence: 90%

Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract

Almodóvar¹,

Briskey

Rao³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…A number of plant components may be responsible for the protective effects of plant foods [ 2 , 11 , 12 ]. Carotenoids have been associated with many health benefits, and they offer an ideal biomarker for fruit and vegetable intake; they are available solely through the diet and dietary supplements, and can be reliably analyzed in serum and tissue samples [ 13 , 14 ]. Blood concentrations of carotenoids are known to respond, at least to some extent, to the consumption of carotenoid-containing foods, which includes by and large fruits and vegetables [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption

et al. 2018

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Fruit and vegetable intake has been associated with a reduced risk of many chronic diseases. These foods are the main dietary source of carotenoids. The aim of the present study was to evaluate the associations between dietary intake and serum concentrations of α- and β-carotene in a sample of young Finnish children from the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention (DIPP) Study. The current analysis comprised 3-day food records and serum samples from 207 children aged 1, 2 and 3 years. Spearman and partial correlations, as well as a cross-classification analyses, were used to assess the relationship between dietary intake and the corresponding biomarkers. Serum concentrations of α- and β-carotene were significantly higher among the 1-year-old compared to the 3-year-old children. Dietary intakes of α- and β-carotene correlated significantly with their respective serum concentrations in all age groups, the association being highest at the age of 1 year (α-carotene r = 0.48; p < 0.001 and β-carotene r = 0.47; p < 0.001), and lowest at the age of 3 years (α-carotene r = 0.44; p < 0.001 and β-carotene r = 0.30; p < 0.001). A cross-classification showed that 72–81% of the participants were correctly classified to the same or adjacent quartile, when comparing the reported dietary intakes and the concentrations of the corresponding carotenoid in serum. The 3-day food record seems to be reasonably valid in the assessment of root vegetable consumption among young Finnish children. Root vegetables were the main dietary source of both carotenoids in all age groups. The high consumption of commercial baby foods among the 1-year-old children was reflected in the relatively high dietary intake and serum concentration of both carotenoids.

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“…β-cryptoxanthin had a significant positive environmental correlation with CRP, indicating that common environmental factors affect traits in the same way (increase or decrease concentrations). Epidemiologic studies have reported an inverse correlation between β-cryptoxanthin and CRP concentrations [ 43 , 44 , 45 , 46 ]. However, studies including intervention trials reported positive or no association between carotenoids and CRP [ 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic and Common Environmental Contributions to Familial Resemblances in Plasma Carotenoid Concentrations in Healthy Families

et al. 2018

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Carotenoids have shown an interindividual variability that may be due to genetic factors. The only study that has reported heritability of serum α- and β-carotene has not considered the environmental component. This study aimed to estimate the contribution of both genetic and common environmental effects to the variance of carotenoid concentrations and to test whether their phenotypic correlations with cardiometabolic risk factors are explained by shared genetic and environmental effects. Plasma carotenoid concentrations (α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene, zeaxanthin, and total carotenoids) of 48 healthy subjects were measured. Heritability estimates of carotenoid concentrations were calculated using the variance component method. Lutein and lycopene showed a significant familial effect (p = 6 × 10−6 and 0.0043, respectively). Maximal heritability, genetic heritability, and common environmental effect were computed for lutein (88.3%, 43.8%, and 44.5%, respectively) and lycopene (45.2%, 0%, and 45.2%, respectively). Significant phenotypic correlations between carotenoid concentrations and cardiometabolic risk factors were obtained for β-cryptoxanthin, lycopene, and zeaxanthin. Familial resemblances in lycopene concentrations were mainly attributable to common environmental effects, while for lutein concentrations they were attributable to genetic and common environmental effects. Common genetic and environmental factors may influence carotenoids and cardiometabolic risk factors, but further studies are needed to better understand the potential impact on disease development.

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Plasma proteins associated with circulating carotenoids in Nepalese school-aged children

Cited by 16 publications

References 57 publications

Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract

Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption

Genetic and Common Environmental Contributions to Familial Resemblances in Plasma Carotenoid Concentrations in Healthy Families

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