Plasma proteins binding of indocyanine green

Muckle, T. J.

doi:10.1016/0006-2944(76)90069-7

Cited by 83 publications

(49 citation statements)

References 12 publications

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“…After intravenous injection ICG is bound to plasma proteins, in 80% to globulins, mainly ax-lipoproteins (MW 200 000) (Muckle, 1976), and thus is confined to the intravascular space. Under physiological conditions ICG is exclusively eliminated from the blood through liver Received 20 December 1996 Revised 7 August 1997 Accepted 21 August 1997 Correspondence to: R.-M. Szeimies, Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany and excreted chemically unchanged into bile.…”

mentioning

confidence: 99%

Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma

Abels

Karrer²,

Bäumler³

et al. 1998

Br J Cancer

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Summary Indocyanine green (ICG) is clinically approved for the determination of liver function, cardiac output and plasma volume. In this pilot study, ICG was used as photosensitizer in combination with a diode laser to treat AIDS-associated Kaposi's sarcoma (KS) in three patients. Directly and up to 50 min after intravenous administration of ICG (2-4 mg kg-' body weight), KS (n = 57), mainly plaque-type, were irradiated using a diode laser (item = 805 nm, 100 J cm-2, 0.5-5W cm-2) matching the absorption maximum. Complete remission of KS (n = 16) was achieved when irradiated 1-30 min after injection of the second dose of ICG (2 x 2 mg kg-' b.w., 30 min apart) with 3-5 W cm-2 and 100 J cm-2. Biopsies (n = 3) revealed necrosis of the tumour 24 h and complete remission 4 weeks after therapy. In general, systemic side-effects were not observed and cosmetic results were very good. However, hyperpigmentation occurred temporarily in lesions located on the lower extremities. These findings show that AIDS-associated KS can be effectively treated after photosensitization with ICG and subsequent irradiation with an appropriate diode laser. However, additional investigations need to elucidate the exact mechanism of action of ICG-mediated phototherapy and have to show the efficacy for the treatment of other highly vascularized solid tumours.

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mentioning

confidence: 99%

Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma

Abels

Karrer²,

Bäumler³

et al. 1998

Br J Cancer

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“…18,19 After intravenous injection, ICG completely binds to plasma proteins and is exclusively distributed in the intravascular space. 20 This makes it a suitable tracer for vessel perfusion. ICG absorbs light in the near-infrared spectral range with a maximum at 805 nm, and emits fluorescence at 835 nm.…”

Section: Indocyanine Greenmentioning

confidence: 99%

Monitoring free flaps using laser‐induced fluorescence of indocyanine green: A preliminary experience

et al. 2002

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In a prospective, clinical study, the clinical utility of indocyanine green for intraoperative monitoring of free tissue transfer was evaluated. The study comprised 20 surgical patients undergoing elective microsurgical procedures. Indocyanine green angiography was performed intraoperatively, immediately after flap inset, and the operating team was blind to the fluoremetric findings. Thereafter, postoperative monitoring was done exclusively by clinical examination (color, temperature, time for recapillarization, and bleeding after puncture). Final outcome was compared with results of perioperative indocyanine (ICG)-imaging, and classified either as total flap loss, partial flap loss, or successful tissue transplantation. A total of 2 (10%) complications was recorded, and included one partial and one total flap loss. Both complications were detected by intraoperative ICG imaging. Another case of intraoperative subclinical arterial spasm at the place of microvascular anastomosis was revealed by dynamic ICG-videography. This flap did not develop postoperative complications. In conclusion, evaluation of perfusion by ICG imaging is feasible in all kinds of microsurgical flaps, irrespective of the type of tissue. Even though not meeting all the criteria of an ideal monitoring device, significant additional information can be obtained. In this study, cases with arterial spasm, venous congestion, and regional hypoperfusion were revealed by intraoperative ICG-videography. There was a strong correlation between intraoperative findings and clinical outcome.

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“…In this article we dem onstrate a significantly (p < 0.05, p < 0.005) increased prevalence of cutaneous microaneurysms in long-term type 1 diabetes depicted by sophisticated ICG fluores cence videomicroscopy [13]. Since ICG binds almost completely to plasma proteins [16], it visualizes even microaneurysms which are filled by plasma alone [ 14,15]. Capillary aneurysms densely packed with blood cells may at times be suspected by capillaroscopy without the use of dyes [5.…”

Section: Discussionmentioning

confidence: 99%

“…ICG fluoresces in the near infrared region of the spectrum with a peak absorption of 805 nm and a peak emission of 835 nm [13]. It binds in more than 95% to plasma proteins [16]. Plasma clearance is biphasic, showing a rapid initial phase with a half-time of 3-4 min and a secondary phase with a half-time of more than I h at low concentrations not relevant for intravital fluorescence videomicroscopy [17], ICG is eliminated by the enterohepatic route and only minimally reabsorbed by the gas trointestinal tract [17],…”

Section: Ethodsmentioning

confidence: 99%

Skin Capillary Aneurysms Detected by Indocyanine Green in Type I Diabetes with and without Retinal Microaneurysms

Zaugg-Vesti¹,

Uk²,

Ziegler

et al. 1995

Int J Microcirc

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Functional diabetic microangiopathy of skin vessels is well known (decreased reactivity of arterioles to various stimuli, increased capillary pressure and permeability). In contrast to conventional capiUaroscopy, recently introduced infrared fluorescence videomicroscopy with indocyanine green allows one to depict capillary aneurysms, even when filled with plasma alone. Seventeen healthy volunteers (mean age 37.7 years), 14 patients with type I diabetes without (31.3 years) and 17 with retinal microaneurysms (46.8 years) were studied. The mean duration of diabetes in patients without retinal microaneurysms was 14.2 years (4-36 years) and in those with retinal microaneurysms 21.5 years (8-49 years). Nailfold capillary aneurysms were present in 3 of 17 healthy controls, in 7 of 14 patients without and in 10 of 17 patients with retinopathy. Patients with type I diabetes with and without retinopathy exhibited significantly more skin microaneurysms (p < 0.05 and < 0.005, respectively) than the controls. The prevalence in the patients with retinal microaneurysms tended to be even higher. Skin capillary aneurysms, which may be depicted in vivo by sophisticated infrared fluorescence videomicroscopy, even when filled by plasma alone, are an important morphological feature of diabetic microangiopathy.

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Plasma proteins binding of indocyanine green

Cited by 83 publications

References 12 publications

Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma

Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma

Monitoring free flaps using laser‐induced fluorescence of indocyanine green: A preliminary experience

Skin Capillary Aneurysms Detected by Indocyanine Green in Type I Diabetes with and without Retinal Microaneurysms

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