Plasma Proteins Interaction with Curcumin Nanoparticles: Implications in Cancer Therapeutics

Yallapu, Murali M.; Ebeling, Mara C.; Jaggi, Meena; Chauhan, Subhash C.

doi:10.2174/1389200211314040012

Cited by 33 publications

(19 citation statements)

References 92 publications

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“…It is formerly considered as a drug possessing anti-angiogenic, anti-inflammation and antioxidation effect (Kwon et al, 2005;Suckow et al, 2006;EI-Azab et al, 2011;. Previous researches in 2013 have demonstrated the antitumor effect of Cum in a series of cancers (Bayet-Robert et al, 2013;Du et al, 2013;Kumaravel et al, 2013;Masuelli et al, 2013;Ono et al, 2013;Wei et al, 2013;Yallapu et al, 2013;Zhang et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Efficacy of Curcumin in Liver Cancer

Dai¹,

Yin²,

Sun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Purpose: Liver cancer, one of the most common cancers in China, is reported to feature relatively high morbidity and mortality. Curcumin (Cum) is considered as a drug possessing anti-angiogenic, anti-inflammation and anti-oxidation effect. Previous research has demonstrated antitumor effects in a series of cancers. Materials and Methods: In this study the in vitro cytotoxicity of Cum was measured by MTT assay and pro-apoptotic effects were assessed by DAPI staining and measurement of caspase-3 activity. In vivo anti-hepatoma efficacy of Cum was assessed with HepG2 xenografts. Results: It is found that Cum dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis. Moreover, Cum delayed the growth of liver cancer in a dose-dependent manner in nude mice. Conclusions: Cum might be a promising phytomedicine in cancer therapy and further efforts are needed to explore this therapeutic strategy.

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Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Efficacy of Curcumin in Liver Cancer

Dai¹,

Yin²,

Sun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…For most biomedical purposes, hard corona will likely improve the interaction between NPs and proteins, membranes, phospholipids, endocytic vesicles, organelles, and DNA (44)(45)(46).…”

Section: Importance Of Protein Corona For Biomedical Application Of Nmentioning

confidence: 99%

How protein coronas determine the fate of engineered nanoparticles in biological environment

Capjak

Goreta

Jurašin

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Nanomedicine is a booming medical field that utilises nanoparticles (NPs) for the development of medicines, medical devices, and diagnostic tools. The behaviour of NPs in vivo may be quite complex due to their interactions with biological molecules. These interactions in biological fluids result in NPs being enveloped by dynamic protein coronas, which serve as an interface between NPs and their environment (blood, cell, tissue). How will the corona interact with this environment will depend on the biological, chemical, and physical properties of NPs, the properties of the proteins that make the corona, as well as the biological environment. This review summarises the main characteristics of protein corona and describes its dynamic nature. It also presents the most common analytical methods to study the corona, including examples of protein corona composition for the most common NPs used in biomedicine. This knowledge is necessary to design NPs that will create a corona with a desired efficiency and safety in clinical use.

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“…Recent studies have demonstrated the interaction of curcumin nanoparticles with plasma proteins, which is a new platform and can be used to improve cancer therapy [103].…”

Section: Curcumin Nanoparticles In the Treatment Of Cancermentioning

confidence: 99%

Potential applications of curcumin and curcumin nanoparticles: from traditional therapeutics to modern nanomedicine

Rai

Pandit²,

Gaikwad³

et al. 2015

Nanotechnology Reviews

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Curcumin (diferuloylmethane) is one of the potent, nontoxic, and major bioactive components present in turmeric. The major drawbacks of curcumin are low absorption and poor bioavailability. The present review highlights on the methods for the fabrication of curcumin nanoparticles and their applications in treatment of cancer and wound infections. Curcumin nanoparticles possess remarkable antibacterial, antiviral, and antiprotozoan activity. Hence, curcumin nanoparticleloaded nano-gel, microemulsion, and nano-cream can be used for drug delivery.

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Plasma Proteins Interaction with Curcumin Nanoparticles: Implications in Cancer Therapeutics

Cited by 33 publications

References 92 publications

Potential Therapeutic Efficacy of Curcumin in Liver Cancer

Potential Therapeutic Efficacy of Curcumin in Liver Cancer

How protein coronas determine the fate of engineered nanoparticles in biological environment

Potential applications of curcumin and curcumin nanoparticles: from traditional therapeutics to modern nanomedicine

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