Plasma Renin Activity and Angiotensin Pressor Dose in Hypertension: Correlation and Diagnostic Implications

Weidmann, P; Endres, P; Siegenthaler, W

doi:10.1136/bmj.3.5611.154

Cited by 38 publications

(10 citation statements)

References 18 publications

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“…In man, exogenous angiotensin II increases the blood pressure the less the higher the plasma renin activity [17], Our present results with rats are in agreement with this finding. The mechanism by which Studies with Pinealectomized Rats 83 the hypertension was induced may have played a role in these varying results.…”

Section: Discussionsupporting

confidence: 83%

Studies with Pinealectomized Rats

Karppanen¹,

Vapaatalo²,

Lahovaara³

et al. 1970

Pharmacology

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Section: Discussionsupporting

confidence: 83%

Studies with Pinealectomized Rats

Karppanen¹,

Vapaatalo²,

Lahovaara³

et al. 1970

Pharmacology

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“…- 32 In our present study, both sodium salts lowered plasma angiotensin II levels and renin activity while enhancing pressor response to angiotensin II in both groups. During both high sodium regimens, however, pressor response was higher and plasma levels of angiotensin II and renin activity tended to be lower in the salt-sensitive than in the salt-resistant subjects.…”

supporting

confidence: 58%

Effects of sodium salts on pressor reactivity in salt-sensitive men.

et al. 1992

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Blood pressure in patients with essential hypertension is raised by sodium chloride but not by nonchloride sodium salts. Although a high sodium chloride diet is known to augment the pressor response to norepinephrine and angiotensin II, the effect of nonchloride sodium salts on pressor responsiveness has not been studied so far. To examine whether sodium chloride and nonchloride sodium salts evoke different pressor responses to these agonists, we performed graded norepinephrine and angiotensin II infusions in salt-sensitive (u=7) and salt-resistant (it=8) normotensive subjects. The subjects were given a low salt diet (20 mmol/day) for 3 weeks, to which a supplement of 200 mmol sodium per day, provided as either sodium chloride or sodium citrate, or a placebo was added for 1 week each. We found that, although sodium chloride raised mean arterial blood pressure in the salt-sensitive subjects (p<0.005), sodium citrate did not However, under both sodium salts pressor response to norepinephrine and angiotensin II was significantly greater than under placebo (p<0.02). Furthermore, with both sodium salts, pressor response in the salt-sensitive subjects was greater than in the salt-resistant subjects (p<0.01). This study thus demonstrates that, although blood pressure in salt-sensitive individuals is raised by sodium chloride only, both sodium chloride and sodium citrate evoke similar increases in pressor response to norepinephrine and angiotensin H. Since pressor response increased with both sodium salts but resting blood pressure increased only with sodium chloride, enhanced pressor responsiveness alone cannot account for the sodium chloride-induced rise in resting blood pressure. (Hypertension 1992;l

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“…As mentioned already, in normal man inverse relationships between pressor factors such as plasma NE or renin levels and pressor responsiveness to NE or angiotensin II, respectively, appear to maintain a physiologic equilibrium [102,139,179,194], possibly as yet another feeedback mechanism in support of blood pressure homeostasis. Consequently, pharmacologic inhibitors of a pressor factor should be capable of lowering blood pressure by this mechanism only if the suppression of the pressor factor is not accompanied by an equivalent increase in pressor reactivity.…”

Section: Pressor Factors As Related To Cardiovascular Reactivitymentioning

confidence: 88%

“…Considering the physiologic inverse relationship between circulating renin and cardiovascular pressor responsiveness to angiotensin II [35], no clearcut abnormality could be demonstrated in patients with established essential hypertension [139,179]. However, preliminary observations in our laboratory suggested that in patients with borderline hypertension [124] or younger hypertensive patients below the age of 45 years [126] pressor responsiveness to angiotensin at a given endogenous plasma renin may be significantly increased; this discrepancy was not apparent in middle-aged and older patients (> 45 yr) with essential hypertension.…”

Section: Pressor Factors As Related To Cardiovascular Reactivitymentioning

confidence: 99%

Recent pathogenic aspects in essential hypertension and hypertension associated with diabetes mellitus

Weidmann

1980

Klin Wochenschr

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The sympathetic system, the body sodium-fluid volume state, the renin-angiotensin system, functional and structural characteristics of the heart and blood vessels, and some other components are important complementary factors in blood pressure regulation. A deviation from the normal equilibrium among these components, with a persisting non-physiologic increase in pressor factor(s) or in the basal vascular tone and/or cardiovascular reactivity to pressor factors, leads to hypertension. This review discusses recent observations and concepts regarding the pathogenesis of essential hypertension and hypertension associated with diabetes mellitus. It focuses on the roles of various pressor factors as well as cardiovascular pressor responsiveness in the genesis of high blood pressure and in the antihypertensive mechanism of diuretic treatment.

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Plasma Renin Activity and Angiotensin Pressor Dose in Hypertension: Correlation and Diagnostic Implications

Cited by 38 publications

References 18 publications

Studies with Pinealectomized Rats

Studies with Pinealectomized Rats

Effects of sodium salts on pressor reactivity in salt-sensitive men.

Recent pathogenic aspects in essential hypertension and hypertension associated with diabetes mellitus

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