Plasma rich in growth factor gel as an autologous filler for facial volume restoration

Abstract

Background Skin aging is characterized by moderate to severe wrinkles, laxity, roughness, and volume loss as a result of cutaneous atrophy and connective tissue degradation. Plasma rich in growth factor gel (PRGF‐gel) is a novel formulation obtained from the patient's own blood that has demonstrated optimal biomechanical and bioactive properties for soft tissue restoration. Objectives Following a retrospective design, the clinical safety and efficacy of PRGF‐gel for facial volume restoration and skin rejuvenation were evaluated. Methods Twenty women clinically diagnosed for aged skin symptoms were treated with PRGF‐gel. Participants received an individualized regimen depending on their therapeutic needs. At the end of the follow‐up periods, clinical performance analysis was evaluated by standardized macrophotographs along with clinical and patient surveys based on Likert's scales. Results Based on their initial expectations, patients referred to be highly satisfied after PRGF‐gel treatment in terms of fine line amelioration, wrinkle reduction, and sagging improvement (overall satisfaction of 8/10). Pre/post‐photograph clinical evaluation showed an improvement of 2.5/3 and patients presented a noticeable face rejuvenation due to the soft tissue augmentation effect which was translated into surface texture softening and tone recovery. Conclusions Although additional randomized clinical trials should be carried out, this study provides preliminary data supporting the use of PRGF‐gel for facial volume restoration.

Effectiveness of Hyaluronic Acid Gel Injection with and without PRGF for Management of Interdental Papillary Loss: A Randomized Clinical Trial

“…The observed greater change in the PRGF group at 6 and 12 weeks may be hypothesized to be related to the fact that PRGF-gel is similar to the native skin environment and resists the physiological forces of tension, pressure and tissue activity, ensuring a long-lasting support, as reported in the dermatological field [ 30 , 31 ]. Hence, we can deduce that it would have similar effects in the gingiva as well.…”

Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis

“…Since its discovery, PRP has been prescribed in the field of regenerative medicine for a wide variety of pathologies, including dermatology [ 74 ], maxillofacial surgery [ 75 , 76 ], traumatology [ 77 , 78 ] or in vitro reproduction [ 79 , 80 , 81 ] among others. Only two systematic reviews with meta-analysis have been published evaluating the beneficial effect of PRP in assisted reproduction.…”

Bioestimuladores Autólogos: Bons Resultados Com Mais Segurança

“…O tratamento demonstrou, através da ação dos diversos fatores de crescimento, entre 1,45 e 1,55 vezes mais fibroblastos dérmicos, que são as principais células no processo de cicatrização, manutenção da integridade do tecido conjuntivo e remodelação da matriz extracelular, além da produção de colágeno endógeno e a síntese de Ácido Hialurônico, aumentando a espessura cutânea e promovendo uma defesa antioxidante. 19…”