Plasma rich in growth factors in dentistry

Glavina, Ana; Boras, Vanja Vučičević; Gabrić, Dragana; Sušić, Mato; Granić, Marko; Pelivan, Ivica

doi:10.21767/amj.2017.3000

Cited by 3 publications

(4 citation statements)

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“…41 Other APCs have also demonstrated success in the management of recurrent aphthous stomatitis and refractory oral lichen planus, in the promotion of apexification (root end closure) in immature teeth requiring endodontic treatment, and in the management of gingival recession defects, leading to restoration of keratinized mucosa across exposed root surfaces. 42 Fig. 5.…”

Section: Dental Implantologymentioning

confidence: 99%

Autologous platelet concentrates in oral surgery: protocols, properties, and clinical applications

O'Sullivan

Ríordáin

2022

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Autologous platelet concentrates (APCs) are a relatively new phenomenon, with initial reports of their regenerative potential published as recently as 1998. Despite their relative infancy, a huge body of evidence exists in support of their capacity to promote osseous and soft tissue regeneration through the physiologic processes of platelet activation and subsequent growth factor release. APCs have transformed many areas of healthcare and are now considered an essential component of the surgical milieu. In this narrative review, we explore the evolution of autologous platelet therapies with a particular emphasis on their contemporary applications in oral surgery, which rather fittingly was the first specialty to report the regenerative potential of APCs. (Oral Surg Oral Med Oral Pathol Oral Radiol 2021;000:1À9)

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Section: Dental Implantologymentioning

confidence: 99%

Autologous platelet concentrates in oral surgery: protocols, properties, and clinical applications

O'Sullivan

Ríordáin

2022

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Clínicamente se ha demostrado que tanto PRP como el plasma rico en fibrina (PRF) son muy útiles en la odontología regenerativa (Martínez et al, 2018), particularmente en endodoncia, periodoncia, diversos procedimientos de medicina y cirugía oral, osteonecrosis y disfunción temporomandibular (Glavina et al, 2017;Xu et al, 2020). Estos hallazgos han permitido la edición del libro de texto sobre el PRP y factores de crecimiento en la odontología restaurativa (Miron & Choukroun, 2017).…”

Section: Odontología Y Cirugía Maxilofacialunclassified

Plasma rico en plaquetas como terapia autóloga en la medicina regenerativa: Revisión narrativa

Aguilar¹,

Cáceres²

2020

CTS

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En las últimas décadas, la terapia de plasma rico en plaquetas (PRP) ha despertado mucha atención en el área de la medicina regenerativa, siendo aplicada a diferentes patologías sistémicas y localizadas. El PRP proporciona diversos factores de crecimiento y proteínas que pueden estimular al proceso de regeneración celular, representa un factor importante para su uso clínico generalizado, en diferentes tejidos en donde el suministro de sangre es lento o limitado y apoya la recuperación, cicatrización, activación biológica de células de defensa, estabilización en la regeneración celular y tisular, teniendo uso clínico en casi todas las especialidades médicas. Esta revisión tiene como objetivo presentar las bases teóricas para la potencial aplicación del PRP y sus factores de crecimiento en tratamientos que buscan una terapia regenerativa por bioestimulación de la aplicación autóloga, en patologías para las cuales aún no existe tratamiento específico. Se revisaron artículos de los últimos 10 años en los buscadores y bases de datos Google Scholar, PubMed y Scopus y se seleccionaron aquellos que pueden ayudar a entender la aplicación de PRP en diversos procesos de regeneración, con miras a utilizarse como un tratamiento alternativo y complementario a pacientes con COVID-19. Se encontró abundante literatura experimental y clínica en el uso de PRP autóloga, en diversos procesos de regeneración, inclusive en neumología e infectología, por lo que amerita comprobar su efecto con protocolos establecidos, en patologías respiratorias severas como apoyo biológico autólogo para activar la respuesta biológica innata de tipo celular.

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“…Plasma rich in growth factors (PRGF) – is a platelet‐rich plasma (PRP) preparation protocol created by Eduardo Anitua. The protocol is unique because it does not include leucocytes in its composition; moreover, PRGF can be used in different clinical forms 4,5 . It is known that the proteins derived from platelets such as platelet‐derived growth factor (PDGF), transforming growth factor (TGF‐β), vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), also plasma containing certain natural growth factors in the name of insulin‐like growth factor (IGF), fibroblast growth factor (b‐FGF) and nerve growth factor (NGF) are able to promote angiogenesis and enhance muscle regeneration 6‐8 .…”

Section: Introductionmentioning

confidence: 99%

“…Since many of the modern MPS treatment methods are solely based on contracted muscle fibre membrane disruption, not the effect of an injectable substance, furthermore, PRGF is a totally autologous substance with no reported side effects, we decided to set up a randomised controlled clinical trial 5 …”

Section: Introductionmentioning

confidence: 99%

Plasma rich in growth factors injection effectiveness for myofascial pain treatment in masticatory muscles. Randomised controlled trial

Šakalys

Rokicki

Janužis

et al. 2020

J of Oral Rehabilitation

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Background Myofascial pain in masticatory muscles is one of the most common temporomandibular disorder. Nowadays, the most usable treatment methods are based on the muscle taut band cell membrane disruption, which releases the taut band. Platelet‐rich plasma, made with PRGF Endoret® method, gives an opportunity to use platelet‐derived growth factors in treatment processes. It has been proven that platelet‐derived growth factors can relief pain and activate muscle regeneration. Objective To test a hypothesis that PRGF injections can be effective for treating myofascial pain in masticatory muscles. Methods Fifty adult patients participated in the study. Participants were randomly divided into two groups. The first group received 1‐mL lidocaine injections to trigger point in their masseter muscle. The second group of patients received 1‐mL PRGF injections. The patients' pain was measured by using visual analogue scale (VAS). Result Statistically significant difference in pain levels before the procedure and 4 weeks after it was found in both groups. There was no statistically significant difference between groups in pain levels before the procedure (P = .063) and 2 weeks after it (P = .123); however, statistically significant difference was noticed 4 weeks after the procedure (P < .001). Four weeks after the procedure, patients' average pain in lidocaine group was 3.4 on VAS, and it was 0.9 in PRGF group. Conclusions PRGF injections in masseter muscle affected by myofascial pain syndrome are an effective treatment method. PRGF injections more effectively relief myofascial pain in masseter muscle than lidocaine injections.

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Plasma rich in growth factors in dentistry

Cited by 3 publications

References 0 publications

Autologous platelet concentrates in oral surgery: protocols, properties, and clinical applications

Autologous platelet concentrates in oral surgery: protocols, properties, and clinical applications

Plasma rico en plaquetas como terapia autóloga en la medicina regenerativa: Revisión narrativa

Plasma rich in growth factors injection effectiveness for myofascial pain treatment in masticatory muscles. Randomised controlled trial

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