Plasma S-adenosylhomocysteine is associated with the risk of cardiovascular events in patients undergoing coronary angiography: a cohort study

Xiao, Yunjun; Zhang, Yuan; Wang, Min; Li, Xinrui; Su, Dongfang; Qiu, Jian; Li, Dan; Yang, Yan; Xia, Min; Liu, Wenhua

doi:10.3945/ajcn.113.058727

Cited by 50 publications

(43 citation statements)

References 31 publications

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“…[20][21][22][23] EGCADC consisted of patients aged from 40 to 80 years old recruited from GCADC and outpatients from Guangdong General Hospital following the same inclusion and exclusion criteria, ascertainment of CAD, questionnaires and study protocol. A total of 2523 CAD patients were included in the EGCADC (1513 from GCADC and another 1010 from Guangdong General Hospital).…”

Section: Study Subjectsmentioning

confidence: 99%

Association of Serum Retinoic Acid With Risk of Mortality in Patients With Coronary Artery Disease

Liu

Chen

et al. 2016

Circulation Research

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In multivariate analyses, the hazard ratios for total mortality among those in the lowest (referent) to highest quartiles of serum RA measured at study entry were 1.0, 0.83, 0.74, and 0.56, respectively (P-trend<0.001). For cardiovascular mortality, the comparable hazard ratios were 1.0, 0.76, 0.69, and 0.60 (P-trend<0.001). Furthermore, high RA levels (defined as >median) were associated with lower risk of total mortality (adjusted hazard ratios, 0.68; 95% confidence interval, 0.50-0.85; P=0.001) and cardiovascular mortality (adjusted hazard ratios, 0.62; 95% confidence interval, 0.45-0.78; P<0.001) compared with low RA (defined as ≤median). rodents. 14 Furthermore, all-trans RA treatment was shown to be effective in restoring the cardioprotective oxytocin-natriuretic peptides system and preventing abnormal cardiac remodeling in the ob/ob mice. 15 Our recent study showed that dietary supplementation of RA attenuated the development of atherosclerotic lesions in apolipoprotein E-deficient mice. 16 The improved effects of RA on cardiovascular diseases were further demonstrated in the in vitro studies that are involved in different types of cardiovascular cells. Activation of retinoid signaling effectively enhanced cholesterol efflux from cholesterol-loaded macrophage foam cells. [16][17][18] RA treatment inhibited the secretion of coagulatory factors from endothelial cells under proinflammatory conditions. Conclusions19 Thus, retinoid therapy may have important implications in limiting or regressing atherosclerotic cardiovascular disease.Although animal studies provided the appealing data that RA supplementation might be a promising therapeutic nutrient for cardiovascular disease, the clinical relevance of circulating RA in the cardiovascular disease have not been carefully investigated before. Therefore, in this study, we prospectively evaluated the relationship of serum RA with the risk of mortality in patients with coronary artery disease (CAD). Methods Study SubjectsStudy participants were recruited between October 2008 and December 2011 as part of the Expanded Guangdong Coronary Artery Disease Cohort (EGCADC).20-23 EGCADC consisted of patients aged from 40 to 80 years old recruited from GCADC and outpatients from Guangdong General Hospital following the same inclusion and exclusion criteria, ascertainment of CAD, questionnaires and study protocol. A total of 2523 CAD patients were included in the EGCADC (1513 from GCADC and another 1010 from Guangdong General Hospital). The patients will be enrolled if they met one of the following inclusion criteria: history of myocardial infarction (MI), angiographic evidence of >50% stenosis in ≥1 coronary vessels, evidence of exercise-induced ischemia by treadmill or nuclear testing, and history of coronary revascularization or documented diagnosis of CAD by an internist or cardiologist. Participants were excluded if they could not walk 1 block, had MI within the past 6 months, malignancy, with missing or incomplete angiographic data, missing blood samples, laboratory me...

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Section: Study Subjectsmentioning

confidence: 99%

Association of Serum Retinoic Acid With Risk of Mortality in Patients With Coronary Artery Disease

Liu

Chen

et al. 2016

Circulation Research

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“…Methylation is essential for critical cell processes, including gene expression and protein function (45,46). SAH, which is one of the most potent in vivo modulators of AdoMet-dependent methylation reactions, is an important regulator of cellular homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…SAH, which accumulates in the setting of hyperhomocysteinemia, has gained attention as an intracellular metabolite that may be responsible for the deleterious actions on the vasculature attributed previously to excess Hcy (46). Our studies are focused on the effects of SAH as a hypomethylating agent that alters endothelial function.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression

Barroso

Florindo

Kalwa³

et al. 2014

Journal of Biological Chemistry

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Background: Methylation of tRNASec facilitates the incorporation of selenocysteine at a UGA codon during translation. Results: Accumulation of the homocysteine precursor S-adenosylhomocysteine decreases tRNA Sec methylation, reducing glutathione peroxidase 1 expression and increasing oxidative stress-induced inflammatory activation of endothelial cells. Conclusion: Methylation modulates the expression of selenoproteins to regulate redox-dependent inflammatory pathways. Significance: Hypomethylation stress promotes a proatherogenic endothelial cell phenotype.

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“…To the best of our knowledge, only one recent cohort study prospectively evaluated the association between plasma SAH levels and CVD risk in patients undergoing coronary angiography (Xiao et al, 2013). The study found that higher plasma SAH concentrations were significantly associated with an increased risk of cardiovascular events, including fatal CVD, nonfatal myocardial infarction, and stroke.…”

Section: Sah and Cardiovascular Diseasementioning

confidence: 95%

“…Several previous cross-sectional and case-control studies have indicated that plasma SAH may be a better indicator of cardiovascular disease than homocysteine (Kerins et al, 2001;Valli et al, 2008;Wagner and Koury, 2007). A recent prospective cohort study also found that higher plasma SAH levels were significantly associated with an increased risk of cardiovascular events and were a better predictor of cardiovascular risk than homocysteine in coronary angiographic patients (Xiao et al, 2013). Furthermore, Liu et al (2008) showed that plasma SAH levels were a more sensitive biomarker of atherosclerosis than homocysteine and were associated with DNA hypomethylation in HHcy mice.…”

Section: Introductionmentioning

confidence: 92%

Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism

Xiao

Huang

et al. 2015

The International Journal of Biochemistry & Cell Biology

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Plasma S-adenosylhomocysteine is associated with the risk of cardiovascular events in patients undergoing coronary angiography: a cohort study

Abstract: Higher concentrations of plasma SAH are independently associated with an increased risk of cardiovascular events among patients undergoing coronary angiography. This trial was registered at www.chictr.org as ChiCTR-RNRC-08000270.

Cited by 50 publications

References 31 publications

Association of Serum Retinoic Acid With Risk of Mortality in Patients With Coronary Artery Disease

Association of Serum Retinoic Acid With Risk of Mortality in Patients With Coronary Artery Disease

Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression

Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism

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